FFAR2 - free fatty acid receptor 2 Gene

中文名称：游离脂肪酸受体 2

种属: Homo sapiens

同用名: FFA2R; GPR43

基因 ID: 2867 | 基因类型: protein coding

关于 FFAR2

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,448,257-35,451,767 (from NCBI)

This gene has 3 transcripts (splice variants), 333 orthologues and 15 paralogues. Biased expression in appendix (RPKM 7.9), bone marrow (RPKM 5.6) and 11 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 GP40 家族的一个成员，这些受体在 19 号染色体上聚集在一起。编码的蛋白质是短链游离脂肪酸的受体，可能参与炎症反应和调节血浆脂质水平。[RefSeq 提供，2009 年 4 月]

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]

FFAR2 基因产物(2)

mRNA	Protein	Name
NM_001370087.1	NP_001357016.1	free fatty acid receptor 2
NM_005306.3	NP_005297.1	free fatty acid receptor 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled receptor activity	IDA IDA: 通过直接分析推断	12496283	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21037097	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	12496283	GOA
involved in cell surface pattern recognition receptor signaling pathway	IMP IMP: 通过突变表型推断	21037097	GOA
involved in cellular response to fatty acid	IDA IDA: 通过直接分析推断	12496283	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: 通过突变表型推断	21037097	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	18801738	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FFAR2 蛋白结构

7tm_1

0
100
200
300
330 a.a.

蛋白主名

其他名称

free fatty acid receptor 2

G-protein coupled receptor 43

FFAR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FFAR2	O15552	EDDM3B	Homo sapiens	P56851	Validated Y2H	32296183
种属内	FFAR2	O15552	SMAGP	Homo sapiens	Q0VAQ4	Validated Y2H	32296183
种属内	FFAR2	O15552	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
种属内	FFAR2	O15552	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
种属内	FFAR2	O15552	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
种属内	FFAR2	O15552	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
种属内	FFAR2	O15552	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
种属内	FFAR2	O15552	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
种属内	FFAR2	O15552	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
种属内	FFAR2	O15552	FAM20B	Homo sapiens	O75063	Validated Y2H	32296183
种属内	FFAR2	O15552	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
种属内	FFAR2	O15552	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
种属内	FFAR2	O15552	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
种属内	FFAR2	O15552	O00602-PRO_0000009136	Homo sapiens	O00602-PRO_0000009136	Y2H	21037097
种属内	FFAR2	O15552	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
种属内	FFAR2	O15552	CLEC1A	Homo sapiens	Q8NC01	Validated Y2H	32296183
种属内	FFAR2	O15552	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
种属内	FFAR2	O15552	KTN1	Homo sapiens	Q86UP2-3	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
种属内	FFAR2	O15552	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
种属内	FFAR2	O15552	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
种属内	FFAR2	O15552	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
种属内	FFAR2	O15552	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
种属内	FFAR2	O15552	CNIH1	Homo sapiens	O95406	Validated Y2H	32296183
种属内	FFAR2	O15552	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
种属内	FFAR2	O15552	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
种属内	FFAR2	O15552	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
种属内	FFAR2	O15552	STRIT1	Homo sapiens	P0DN84	Validated Y2H	32296183
种属内	FFAR2	O15552	COL4A5	Homo sapiens	P29400-2	Validated Y2H	32296183
种属内	FFAR2	O15552	UPK1B	Homo sapiens	O75841	Validated Y2H	32296183
种属内	FFAR2	O15552	GUCA2A	Homo sapiens	Q02747	Validated Y2H	32296183
种属内	FFAR2	O15552	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
种属内	FFAR2	O15552	SCGB1D1	Homo sapiens	O95968	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM144	Homo sapiens	Q7Z5S9	Validated Y2H	32296183
种属内	FFAR2	O15552	OR10AG1	Homo sapiens	Q8NH19	Validated Y2H	32296183
种属内	FFAR2	O15552	SLC35E3	Homo sapiens	Q7Z769	Y2H Prey Pooling	32296183
种属内	FFAR2	O15552	SLC35E3	Homo sapiens	Q7Z769	Validated Y2H	32296183
种属内	FFAR2	O15552	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
种属内	FFAR2	O15552	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
种属内	FFAR2	O15552	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
种属内	FFAR2	O15552	YIF1A	Homo sapiens	O95070	Validated Y2H	32296183
种属内	FFAR2	O15552	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
种属内	FFAR2	O15552	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
种属内	FFAR2	O15552	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
种属内	FFAR2	O15552	C11orf24	Homo sapiens	Q96F05	Validated Y2H	32296183
种属内	FFAR2	O15552	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
种属内	FFAR2	O15552	NAT8	Homo sapiens	Q9UHE5	Validated Y2H	32296183
种属内	FFAR2	O15552	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
种属内	FFAR2	O15552	GPR37L1	Homo sapiens	O60883	Validated Y2H	32296183
种属内	FFAR2	O15552	KRT1	Homo sapiens	P04264	Validated Y2H	32296183
种属内	FFAR2	O15552	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
种属内	FFAR2	O15552	TNF	Homo sapiens	P01375	Validated Y2H	32296183
种属内	FFAR2	O15552	ALOX5AP	Homo sapiens	P20292	Validated Y2H	32296183
种属内	FFAR2	O15552	GJB2	Homo sapiens	P29033	Validated Y2H	32296183
种属内	FFAR2	O15552	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
种属内	FFAR2	O15552	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
种属内	FFAR2	O15552	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
种属内	FFAR2	O15552	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
种属内	FFAR2	O15552	BMP10	Homo sapiens	O95393	Validated Y2H	32296183
种属内	FFAR2	O15552	GALNT15	Homo sapiens	Q8N3T1	Validated Y2H	32296183
种属内	FFAR2	O15552	CBLIF	Homo sapiens	P27352	Validated Y2H	32296183
种属内	FFAR2	O15552	DERL1	Homo sapiens	Q9BUN8	Validated Y2H	32296183
种属内	FFAR2	O15552	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
种属内	FFAR2	O15552	NSG1	Homo sapiens	P42857	Validated Y2H	32296183
种属内	FFAR2	O15552	CD82	Homo sapiens	P27701	Validated Y2H	32296183
种属内	FFAR2	O15552	GYPA	Homo sapiens	P02724	Validated Y2H	32296183
种属内	FFAR2	O15552	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
种属内	FFAR2	O15552	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
种属内	FFAR2	O15552	APOD	Homo sapiens	P05090	Validated Y2H	32296183
种属内	FFAR2	O15552	ATP6V0C	Homo sapiens	P27449	Validated Y2H	32296183
种属内	FFAR2	O15552	LAPTM4A	Homo sapiens	Q15012	Validated Y2H	32296183
种属内	FFAR2	O15552	TMEM11	Homo sapiens	P17152	Validated Y2H	32296183
种属内	FFAR2	O15552	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	32296183
种属内	FFAR2	O15552	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
种属内	FFAR2	O15552	FZD7	Homo sapiens	O75084	Validated Y2H	32296183
种属内	FFAR2	O15552	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
种属内	FFAR2	O15552	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
种属内	FFAR2	O15552	LEPROTL1	Homo sapiens	O95214	Validated Y2H	32296183
种属内	FFAR2	O15552	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
种属内	FFAR2	O15552	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
种属内	FFAR2	O15552	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
种属内	FFAR2	O15552	IFITM3	Homo sapiens	Q01628	Validated Y2H	32296183
种属内	FFAR2	O15552	LAT	Homo sapiens	O43561-2	Validated Y2H	32296183
种属内	FFAR2	O15552	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
种属内	FFAR2	O15552	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
种属内	FFAR2	O15552	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
种属内	FFAR2	O15552	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
种属内	FFAR2	O15552	TM4SF4	Homo sapiens	P48230	Validated Y2H	32296183
种属内	FFAR2	O15552	PNLIPRP1	Homo sapiens	P54315	Validated Y2H	32296183
种属内	FFAR2	O15552	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183
种属内	FFAR2	O15552	NIPAL4	Homo sapiens	Q0D2K0	Validated Y2H	32296183
种属内	FFAR2	O15552	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183
种属内	FFAR2	O15552	CACNG1	Homo sapiens	Q06432	Validated Y2H	32296183
种属内	FFAR2	O15552	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183
种属内	FFAR2	O15552	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

FFAR2 抗体

目录号	产品名	应用	反应物种
HY-P81225	GPR43 Antibody	ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse

关联疾病

疾病名称

别名

Diversion Colitis

Inflammatory Bowel Disease 16

IBD16

Inflammatory Bowel Disease 16, Susceptibility To

Constipation

Autotopagnosia

Body-Image Agnosia

Anaerobic Meningitis

Noonan Syndrome 8

NS8	Noonan Syndrome, Type 8

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-114060	CFMB		/	否
HY-RS16257	Ffar2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04875	FFAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FFAR2	VGNC	VGNC:40831
Macaca mulatta	FFAR2	VGNC	VGNC:72706
Mus musculus	FFAR2	MGD	MGI:2441731
Rattus norvegicus	FFAR2	RGD	RGD:1359614

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4