ALOX5AP - arachidonate 5-lipoxygenase activating protein Gene

中文名称：花生四烯酸 5-脂氧合酶激活蛋白

种属: Homo sapiens

同用名: FLAP

基因 ID: 241 | 基因类型: protein coding

关于 ALOX5AP

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,713,485-30,764,426 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 94.5), lung (RPKM 39.9) and 14 other tissues.

功能概要

该基因编码的蛋白质与 5-脂氧合酶一起是白三烯合成所必需的。白三烯是花生四烯酸代谢物，与各种类型的炎症反应有关，包括哮喘、关节炎和牛皮癣。这种蛋白质定位于质膜。其功能的抑制剂阻碍 5-脂氧合酶从细胞质转移到细胞膜并抑制 5-脂氧合酶活化。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 2 月]

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

ALOX5AP 基因产物(3)

mRNA	Protein	Name
NM_001204406.2	NP_001191335.1	arachidonate 5-lipoxygenase-activating protein isoform 2
NM_001629.4	NP_001620.2	arachidonate 5-lipoxygenase-activating protein isoform 1
XM_017020522.3	XP_016876011.1	arachidonate 5-lipoxygenase-activating protein isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables arachidonate binding	IDA IDA: 通过直接分析推断	8440384	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19233132	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to calcium ion	IDA IDA: 通过直接分析推断	2300173	GOA
involved in leukotriene biosynthetic process	IDA IDA: 通过直接分析推断	2300173	GOA
involved in protein homotrimerization	IPI IPI: 通过物理相互作用推断	17600184	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	19233132	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	19233132	GOA
located in nuclear membrane	IDA IDA: 通过直接分析推断	8245774	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALOX5AP 蛋白结构

MAPEG

0
100
161 a.a.

蛋白主名

其他名称

arachidonate 5-lipoxygenase-activating protein

MK-886-binding protein

ALOX5AP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ALOX5AP	P20292	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
种属内	ALOX5AP	P20292	OPRM1	Homo sapiens	P35372-10	Validated Y2H	32296183
种属内	ALOX5AP	P20292	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
种属内	ALOX5AP	P20292	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	ALOX5AP	P20292	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
种属内	ALOX5AP	P20292	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	ALOX5AP	P20292	GPR42	Homo sapiens	O15529	Y2H Array	32296183
种属内	ALOX5AP	P20292	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
种属内	ALOX5AP	P20292	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
种属内	ALOX5AP	P20292	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
种属内	ALOX5AP	P20292	q96fb2_human	Homo sapiens	Q96FB2	Validated Y2H	32296183
种属内	ALOX5AP	P20292	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

ALOX5AP 抗体

目录号	产品名	应用	反应物种
HY-P82958	FLAP Antibody (YA2703)	WB	Human

关联疾病

疾病名称

别名

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Disease Of Subdivision Of Hemolymphoid System
Disorder Of Cardiovascular System	Cardiovascular Diseases
Cardiovascular Disease

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Disease, Susceptibility To
Coronary Artery Anomaly	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Persistent Mild Asthma

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Macular Holes

Macular Hole

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00623	ALOX5AP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00624	Alox5ap Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00625	Alox5ap Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ALOX5AP	VGNC	VGNC:25845
Macaca mulatta	ALOX5AP	VGNC	VGNC:69799
Rattus norvegicus	ALOX5AP	RGD	RGD:2097
Mus musculus	ALOX5AP	MGD	MGI:107505
Canis familiaris	ALOX5AP	VGNC	VGNC:59072
Felis catus	ALOX5AP	VGNC	VGNC:102156

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ALOX5AP - arachidonate 5-lipoxygenase activating protein Gene

关于 ALOX5AP

功能概要

ALOX5AP 基因产物(3)

ALOX5AP 蛋白结构

ALOX5AP 蛋白互作信息

ALOX5AP 抗体

关联疾病

直系同源

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ALOX5AP - arachidonate 5-lipoxygenase activating protein Gene

关于 ALOX5AP

功能概要

ALOX5AP 基因产物(3)

ALOX5AP 蛋白结构

ALOX5AP 蛋白互作信息

ALOX5AP 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z