NAPB - NSF attachment protein beta Gene

中文名称：NSF 附着蛋白 β

种属: Homo sapiens

同用名: SNAPB; DEE107; SNAP-BETA

基因 ID: 63908 | 基因类型: protein coding

关于 NAPB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,374,522-23,421,488 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 118.1) and adrenal (RPKM 14.6).

功能概要

该基因编码可溶性 N-乙基-马来酰亚胺敏感融合附着蛋白 (SNAP) 家族的成员。作为 20S NSF-SNAP-SNARE 复合物的一部分，SNAP 蛋白在囊泡与靶膜的对接和融合中起着关键作用。该基因编码已显示优先在脑组织中表达的 SNAP beta 亚型。编码的蛋白质还与 GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) 受体亚基 C 端相互作用，并可能在 AMPA 受体的分子加工过程中发挥伴侣作用.[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA Receptor. [provided by RefSeq, Mar 2017]

NAPB 基因产物(4)

mRNA	Protein	Name
NM_001283018.2	NP_001269947.1	beta-soluble NSF attachment protein isoform a
NM_001283020.2	NP_001269949.1	beta-soluble NSF attachment protein isoform c
NM_001283026.2	NP_001269955.1	beta-soluble NSF attachment protein isoform d
NM_022080.3	NP_071363.1	beta-soluble NSF attachment protein isoform b

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21516116	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAPB 蛋白结构

SNAP

0
100
200
298 a.a.

蛋白主名

其他名称

beta-soluble NSF attachment protein

N-ethylmaleimide-sensitive factor attachment protein, beta

NAPB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NAPB	Q9H115	SNAP23	Homo sapiens	A8K287	Validated Y2H	25416956
种属内	NAPB	Q9H115	SNAP23	Homo sapiens	A8K287	Y2H Array	25416956
种属内	NAPB	Q9H115	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
种属内	NAPB	Q9H115	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
种属内	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Array	32296183
种属内	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Validated Y2H	25416956
种属内	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Array	29892012
种属内	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Array	31515488
种属内	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Prey Pooling	25416956
种属内	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
种属内	NAPB	Q9H115	KCNN3	Homo sapiens	Q9UGI6-2	Validated Y2H	32296183
种属内	NAPB	Q9H115	KCNN3	Homo sapiens	Q9UGI6-2	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
种属内	NAPB	Q9H115	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
种属内	NAPB	Q9H115	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	STX6	Homo sapiens	O43752	Validated Y2H	25416956
种属内	NAPB	Q9H115	STX6	Homo sapiens	O43752	Y2H	21516116
种属内	NAPB	Q9H115	STX16	Homo sapiens	O14662	Y2H Array	25416956
种属内	NAPB	Q9H115	STX16	Homo sapiens	O14662	Y2H Prey Pooling	25416956
种属内	NAPB	Q9H115	STX16	Homo sapiens	O14662	Validated Y2H	25416956
种属内	NAPB	Q9H115	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
种属内	NAPB	Q9H115	ALOX5AP	Homo sapiens	P20292	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	ALOX5AP	Homo sapiens	P20292	Y2H Array	32296183
种属内	NAPB	Q9H115	GJB5	Homo sapiens	O95377	Y2H Array	32296183
种属内	NAPB	Q9H115	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	TFEC	Homo sapiens	O14948	Validated Y2H	25416956
种属内	NAPB	Q9H115	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	SNAP29	Homo sapiens	O95721	Y2H Array	32296183
种属内	NAPB	Q9H115	SYT1	Homo sapiens	P21579	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	SYT1	Homo sapiens	P21579	Y2H Array	32296183
种属内	NAPB	Q9H115	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
种属内	NAPB	Q9H115	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Y2H Array	25416956
种属内	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Y2H Array	32296183
种属内	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Validated Y2H	25416956
种属内	NAPB	Q9H115	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
种属内	NAPB	Q9H115	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
种属内	NAPB	Q9H115	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
种属内	NAPB	Q9H115	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	25416956
种属内	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Validated Y2H	25416956
种属内	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Array	25416956
种属内	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Array	32296183
种属内	NAPB	Q9H115	SNAP23	Homo sapiens	O00161	Validated Y2H	25416956
种属内	NAPB	Q9H115	BET1	Homo sapiens	O15155	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	BET1	Homo sapiens	O15155	Y2H Array	32296183
种属内	NAPB	Q9H115	SIGLEC5	Homo sapiens	O15389	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	SIGLEC5	Homo sapiens	O15389	Y2H Array	32296183
种属内	NAPB	Q9H115	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183
种属内	NAPB	Q9H115	STX19	Homo sapiens	Q8N4C7	Y2H Array	32296183
种属内	NAPB	Q9H115	STX19	Homo sapiens	Q8N4C7	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
种属内	NAPB	Q9H115	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Developmental And Epileptic Encephalopathy 107

DEE107

Developmental And Epileptic Encephalopathy-107

Amyotrophy, Hereditary Neuralgic

Hereditary Neuralgic Amyotrophy	Neuritis With Brachial Predilection
HNA	Napb
Brachial Plexus Neuropathy, Hereditary	Hereditary Brachial Plexus Neuropathy
Amyotrophy, Hereditary Neuralgic, With Predilection For Brachial Plexus	Brachial Neuralgia
Brachial Plexus Neuritis	Neuralgic Amyotrophy
Amyotrophic Neuralgia	Brachial Neuritis
Familial Brachial Plexus Neuritis	Heredofamilial Neuritis With Brachial Plexus Predilection
Shoulder Girdle Neuropathy	Hereditary Neuralgic Amyotrophy With Predilection For Brachial Plexus
Amyotrophy, Neuralgic, Hereditary	Acute Brachial Neuritis

Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder	Obsessive-Compulsive Personality
Compulsive Personality Disorder	Ocpd
Obsessional Personality Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09030	NAPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NAPB	VGNC	VGNC:43620
Mus musculus	NAPB	MGD	MGI:104562
Felis catus	NAPB	VGNC	VGNC:81129
Macaca mulatta	NAPB	VGNC	VGNC:74963
Bos taurus	NAPB	VGNC	VGNC:31882
Rattus norvegicus	NAPB	RGD	RGD:1589649

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