2. Gene
  3. STX4 - syntaxin 4 Gene

STX4 - syntaxin 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：突触蛋白 4

种属: Homo sapiens

同用名: STX4A; p35-2

基因 ID: 6810 | 基因类型: protein coding

关于 STX4

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,033,095-31,040,168 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 17.8), adrenal (RPKM 16.5) and 25 other tissues.

功能概要

启用鞘磷脂磷酸二酯酶激活剂活性。涉及多个过程，包括角化信封组装；免疫效应过程的正向调节；和蛋白质定位的正调节。位于几种细胞成分中，包括基底外侧质膜；细胞质囊泡；和片状足。 SNARE 复合体的一部分。活跃于谷氨酸能突触和突触后。 [由基因组资源联盟提供，2022 年 4 月]

Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

STX4 基因产物(3)

mRNA Protein Name
NM_001272095.1 NP_001259024.1 syntaxin-4 isoform 1
NM_001272096.1 NP_001259025.1 syntaxin-4 isoform 2
NM_004604.5 NP_004595.2 syntaxin-4 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12130530 GOA
enables sphingomyelin phosphodiesterase activator activity IMP
IMP: 通过突变表型推断
20956541 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
22226963 GOA
involved in cornified envelope assembly IDA
IDA: 通过直接分析推断
22226963 GOA
involved in long-term synaptic potentiation IDA
IDA: 通过直接分析推断
20434989 GOA
involved in organelle fusion IDA
IDA: 通过直接分析推断
20434989 GOA
involved in positive regulation of catalytic activity IMP
IMP: 通过突变表型推断
20956541 GOA
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
21720706 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
15351710 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21720706 GOA
involved in positive regulation of chemotaxis IMP
IMP: 通过突变表型推断
21720706 GOA
involved in positive regulation of eosinophil degranulation IMP
IMP: 通过突变表型推断
16677249 GOA
involved in positive regulation of immunoglobulin production IMP
IMP: 通过突变表型推断
24055037 GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
24552216 GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
12855681 GOA
involved in positive regulation of protein localization to cell surface IMP
IMP: 通过突变表型推断
21720706 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
15351710 GOA
involved in regulation of exocytosis IMP
IMP: 通过突变表型推断
20434989 GOA
involved in regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
20956541 GOA
involved in sensory perception of sound IMP
IMP: 通过突变表型推断
36355422 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SNARE complex IDA
IDA: 通过直接分析推断
12130530 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
16339081 GOA
located in cell surface IDA
IDA: 通过直接分析推断
15576373 GOA
located in dendritic spine IDA
IDA: 通过直接分析推断
20434989 GOA
located in endosome IDA
IDA: 通过直接分析推断
20956541 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
22226963 GOA
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
27662481 GOA
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
27662481 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
21720706 GOA
located in membrane IDA
IDA: 通过直接分析推断
7690687 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
20956541 GOA
is active in postsynapse IDA
IDA: 通过直接分析推断
27662481 GOA
is active in postsynapse IMP
IMP: 通过突变表型推断
27662481 GOA
located in somatodendritic compartment IDA
IDA: 通过直接分析推断
20434989 GOA
located in specific granule IDA
IDA: 通过直接分析推断
18588921 GOA
located in synapse IDA
IDA: 通过直接分析推断
20434989 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STX4 蛋白结构

Syntaxin

Syntaxin: Syntaxin (39 - 137)

SNARE

SNARE: SNARE domain (206 - 267)

  • 0
  • 100
  • 200
  • 297 a.a.
蛋白主名 其他名称

syntaxin-4

renal carcinoma antigen NY-REN-31

STX4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra STX4 Q12846 VAMP5 Homo sapiens O95183
Y2H Array
32296183
Intra STX4 Q12846 VAMP5 Homo sapiens O95183
Y2H Prey Pooling
32296183
Intra STX4 Q12846 SNAP47 Homo sapiens Q5SQN1
Y2H Prey Pooling
25416956
Intra STX4 Q12846 SNAP47 Homo sapiens Q5SQN1
Y2H Array
25416956
Intra STX4 Q12846 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
25416956
Intra STX4 Q12846 TMEM199 Homo sapiens Q8N511
Validated Y2H
32296183
Intra STX4 Q12846 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra STX4 Q12846 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra STX4 Q12846 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra STX4 Q12846 SEC22B Homo sapiens O75396
Anti Bait CoIP
22153078
Intra STX4 Q12846 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra STX4 Q12846 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra STX4 Q12846 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra STX4 Q12846 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra STX4 Q12846 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra STX4 Q12846 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Intra STX4 Q12846 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra STX4 Q12846 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra STX4 Q12846 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra STX4 Q12846 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Array
29892012
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Array
31515488
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Validated Y2H
32296183
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Array
25416956
Intra STX4 Q12846 STX3 Homo sapiens Q13277
Y2H Prey Pooling
25416956
Intra STX4 Q12846 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra STX4 Q12846 RNF4 Homo sapiens P78317
Y2H Array
32296183
Cross STX4 Q12846 ap3a_sars2 SARS-CoV-2 P0DTC3
Confocal
34706264
Cross STX4 Q12846 ap3a_sars2 SARS-CoV-2 P0DTC3
Anti Tag CoIP
34706264
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Y2H Array
31515488
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Validated Y2H
25416956
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Validated Y2H
32296183
Intra STX4 Q12846 STX12 Homo sapiens Q86Y82
Y2H Array
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Validated Y2H
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Y2H Array
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX6 Homo sapiens O43752
Y2H
21516116
Intra STX4 Q12846 STX16 Homo sapiens O14662
Y2H Array
25416956
Intra STX4 Q12846 STX16 Homo sapiens O14662
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX16 Homo sapiens O14662
Validated Y2H
25416956
Intra STX4 Q12846 STX7 Homo sapiens O15400
Validated Y2H
25416956
Intra STX4 Q12846 STX7 Homo sapiens O15400
Y2H
21516116
Intra STX4 Q12846 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra STX4 Q12846 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra STX4 Q12846 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra STX4 Q12846 GOSR2 Homo sapiens O14653
Validated Y2H
25416956
Intra STX4 Q12846 GOSR2 Homo sapiens O14653
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VAMP2 Homo sapiens P63027
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VAMP2 Homo sapiens P63027
Y2H Array
25416956
Intra STX4 Q12846 VAMP2 Homo sapiens P63027
Validated Y2H
25416956
Intra STX4 Q12846 GIMAP5 Homo sapiens Q96F15
Y2H Prey Pooling
25416956
Intra STX4 Q12846 GIMAP5 Homo sapiens Q96F15
Validated Y2H
25416956
Intra STX4 Q12846 GIMAP5 Homo sapiens Q96F15
Y2H Array
25416956
Intra STX4 Q12846 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra STX4 Q12846 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra STX4 Q12846 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Validated Y2H
25416956
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Validated Y2H
32296183
Intra STX4 Q12846 STX5 Homo sapiens Q13190
Y2H Array
25416956
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Anti Tag CoIP
25416956
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Anti Bait CoIP
12130530
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Y2H Pooling
16189514
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Validated Y2H
32296183
Intra STX4 Q12846 VAMP3 Homo sapiens Q15836
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VTI1B Homo sapiens Q9UEU0
Validated Y2H
25416956
Intra STX4 Q12846 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra STX4 Q12846 VTI1B Homo sapiens Q9UEU0
Y2H Prey Pooling
25416956
Intra STX4 Q12846 STX8 Homo sapiens Q9UNK0
Validated Y2H
25416956
Intra STX4 Q12846 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra STX4 Q12846 STX8 Homo sapiens Q9UNK0
Y2H Array
25416956
Intra STX4 Q12846 USE1 Homo sapiens Q9NZ43
Validated Y2H
32296183
Intra STX4 Q12846 VAMP4 Homo sapiens O75379
Validated Y2H
25416956
Intra STX4 Q12846 VAMP4 Homo sapiens O75379
Y2H Prey Pooling
25416956
Intra STX4 Q12846 VAMP4 Homo sapiens O75379
Y2H Pooling
16189514
Intra STX4 Q12846 BET1 Homo sapiens O15155
Y2H Array
25416956
Intra STX4 Q12846 NAPA Homo sapiens P54920
Y2H Pooling
16189514
Intra STX4 Q12846 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Intra STX4 Q12846 CYBRD1 Homo sapiens Q53TN4
Validated Y2H
25416956
Intra STX4 Q12846 CYBRD1 Homo sapiens Q53TN4
Y2H Array
25416956
Intra STX4 Q12846 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
25416956
Intra STX4 Q12846 SEC22A Homo sapiens Q96IW7
Y2H Prey Pooling
25416956
Intra STX4 Q12846 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Type 1 Diabetes Mellitus 10

Diabetes Mellitus, Insulin-Dependent, 10

IDDM10

Insulin-Dependent Diabetes Mellitus 10

Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10

T1D10

Diabetes, Mellitus, Insulin-Dependent 10

Diabetes Mellitus, Insulin-Dependent, Type 10
Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4

FHL4

Hplh4

Hlh4

Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13984 STX4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STX4 VGNC VGNC:99601
Felis catus STX4 VGNC VGNC:65814
Mus musculus STX4 MGD MGI:893577
Canis familiaris STX4 VGNC VGNC:46956
Rattus norvegicus STX4 RGD RGD:621019
Bos taurus STX4 VGNC VGNC:35440
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