1. Gene
  2. USE1 - unconventional SNARE in the ER 1 Gene

USE1 - unconventional SNARE in the ER 1 Gene

中文名称:ER 1 中的非常规 SNARE

种属: Homo sapiens

同用名: D12; P31; SLT1; MDS032

基因 ID: 55850 | 基因类型: protein coding

关于 USE1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,215,357-17,219,829 (from NCBI)

This gene has 9 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in brain (RPKM 7.1), fat (RPKM 6.8) and 25 other tissues.

功能概要

预测启用 SNAP 受体活性。预计参与多个过程,包括溶酶体运输;蛋白质分解代谢过程;和逆行囊泡介导的运输,高尔基体到内质网。预计在内质网管状网络组织的上游或内部起作用,并调节 ER 到高尔基体囊泡介导的运输。位于内质网。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable SNAP receptor activity. Predicted to be involved in several processes, including lysosomal transport; protein catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

USE1 基因产物(1)

mRNA Protein Name
NM_018467.4 NP_060937.2 vesicle transport protein USE1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15029241 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15029241 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

USE1 蛋白结构

Use1

Use1: Membrane fusion protein Use1 (4 - 255)

  • 0
  • 100
  • 200
  • 259 a.a.
蛋白主名 其他名称

vesicle transport protein USE1

Q-SNARE

USE1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra USE1 Q9NZ43 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra USE1 Q9NZ43 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra USE1 Q9NZ43 CALN1 Homo sapiens Q9BXU9
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 CALN1 Homo sapiens Q9BXU9
Y2H Array
32296183
Intra USE1 Q9NZ43 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra USE1 Q9NZ43 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra USE1 Q9NZ43 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra USE1 Q9NZ43 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 CCM2L Homo sapiens Q9NUG4
Y2H Array
32296183
Intra USE1 Q9NZ43 CCM2L Homo sapiens Q9NUG4
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra USE1 Q9NZ43 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra USE1 Q9NZ43 APOL2 Homo sapiens Q9BQE5
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 APOL2 Homo sapiens Q9BQE5
Y2H Array
32296183
Intra USE1 Q9NZ43 CCDC70 Homo sapiens Q6NSX1
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 CCDC70 Homo sapiens Q6NSX1
Y2H Array
32296183
Intra USE1 Q9NZ43 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra USE1 Q9NZ43 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Pull Down
19369418
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Bait CoIP
19369418
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
33961781
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
28514442
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
19369418
Intra USE1 Q9NZ43 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 STX4 Homo sapiens Q12846
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood Malignant Schwannoma

Pediatric Mpnst

Childhood Neurofibrosarcoma

Anteroseptal Myocardial Infarction
Infantile Liver Failure Syndrome

Infantile Liver Failure

Macular Degeneration, Age-Related, 8

Age Related Macular Degeneration 8

ARMD8

Macular Degeneration, Age-Related, Type 8

Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases

Acoustic Nerve Disease

Cochlear Nerve Diseases

Disturbance Of Vestibulocochlear Nerve

Auditory Nerve Disorder

Disorder Of Acoustovestibular Nerve

Disorder Of Eighth Nerve

Eighth Cranial Nerve Disorder

Disease Of Eighth Cranial Nerve

Disease Of Acoustic Nerve

Disease Of Auditory Nerve

Disorder Of 8th Cranial Nerve

Auditory Nerve Lesion

Cochlear Nerve Disorder

Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis

Pelger-Huet Anomaly

PHA

Pelger-Huët Anomaly

Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities

Pelger Huet Anomaly

Pelger-Huet Nuclear Anomaly

Dysostosis

Dysostoses

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus USE1 RGD RGD:1306660
Felis catus USE1 VGNC VGNC:66859
Bos taurus USE1 VGNC VGNC:107017
Mus musculus USE1 MGD MGI:1914273
Macaca mulatta USE1 VGNC VGNC:79892
Canis familiaris USE1 VGNC VGNC:48171
Others USE1 NCBI