1. Gene
  2. STX1A - syntaxin 1A Gene

STX1A - syntaxin 1A Gene

中文名称:突触蛋白 1A

种属: Homo sapiens

同用名: STX1; HPC-1; P35-1; SYN1A

基因 ID: 6804 | 基因类型: protein coding

关于 STX1A

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,699,210-73,719,669 (from NCBI)

This gene has 14 transcripts (splice variants), 199 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 28.2), bone marrow (RPKM 2.7) and 3 other tissues.

功能概要

该基因编码突触融合蛋白超家族的一个成员。突触融合蛋白是神经系统特异性蛋白质,涉及突触小泡与突触前质膜的对接。突触融合蛋白具有一个 C 端跨膜结构域、一个 SNARE [可溶性 NSF (N-乙基马来酰亚胺敏感融合蛋白) - 附着蛋白受体] 结构域 (称为 H3) 和一个 N 端调节结构域 (Habc) 。突触融合蛋白以钙依赖性方式结合突触结合蛋白,并通过 C 端 H3 结构域与电压依赖性钙通道和钾通道相互作用。该基因产物是离子通道调节和突触胞吐的关键分子。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2009 年 9 月]

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

STX1A 基因产物(2)

mRNA Protein Name
NM_001165903.2 NP_001159375.1 syntaxin-1A isoform 2
NM_004603.4 NP_004594.1 syntaxin-1A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chloride channel inhibitor activity IDA
IDA: 通过直接分析推断
18570918 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
24722188 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
12730201 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10321247 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein sumoylation IDA
IDA: 通过直接分析推断
26635000 GOA
involved in secretion by cell IDA
IDA: 通过直接分析推断
12130530 GOA
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
26635000 GOA
involved in synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
26635000 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SNARE complex IDA
IDA: 通过直接分析推断
12730201 GOA
located in neuron projection IDA
IDA: 通过直接分析推断
12115694 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12730201 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

STX1A 蛋白结构

Syntaxin

Syntaxin: Syntaxin (29 - 131)

SNARE

SNARE: SNARE domain (198 - 259)

  • 0
  • 100
  • 200
  • 288 a.a.
蛋白主名 其他名称

syntaxin-1A

neuron-specific antigen HPC-1

STX1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra STX1A Q16623 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra STX1A Q16623 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra STX1A Q16623 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra STX1A Q16623 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra STX1A Q16623 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra STX1A Q16623 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
32296183
Intra STX1A Q16623 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra STX1A Q16623 TMEM199 Homo sapiens Q8N511
Validated Y2H
32296183
Intra STX1A Q16623 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra STX1A Q16623 TMEM41A Homo sapiens Q96HV5
Validated Y2H
32296183
Intra STX1A Q16623 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra STX1A Q16623 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra STX1A Q16623 PLPP4 Homo sapiens Q5VZY2
Validated Y2H
32296183
Intra STX1A Q16623 CYB5B Homo sapiens O43169
Y2H Array
32296183
Intra STX1A Q16623 TMEM128 Homo sapiens Q5BJH2-2
Validated Y2H
32296183
Intra STX1A Q16623 ZNF557 Homo sapiens Q8N988-2
Validated Y2H
32296183
Intra STX1A Q16623 ZNF479 Homo sapiens Q96JC4
Validated Y2H
32296183
Intra STX1A Q16623 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
Intra STX1A Q16623 ZNF696 Homo sapiens Q9H7X3
Validated Y2H
32296183
Intra STX1A Q16623 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra STX1A Q16623 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra STX1A Q16623 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra STX1A Q16623 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra STX1A Q16623 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra STX1A Q16623 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra STX1A Q16623 TMEM254 Homo sapiens Q8TBM7
Validated Y2H
32296183
Intra STX1A Q16623 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra STX1A Q16623 SNORC Homo sapiens Q6UX34
Validated Y2H
32296183
Intra STX1A Q16623 GIMAP1 Homo sapiens Q8WWP7
Validated Y2H
32296183
Intra STX1A Q16623 CLEC1A Homo sapiens Q8NC01
Validated Y2H
32296183
Intra STX1A Q16623 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra STX1A Q16623 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra STX1A Q16623 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra STX1A Q16623 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra STX1A Q16623 ZNF441 Homo sapiens Q8N8Z8
Validated Y2H
32296183
Intra STX1A Q16623 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra STX1A Q16623 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra STX1A Q16623 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra STX1A Q16623 STX12 Homo sapiens Q86Y82
Validated Y2H
32296183
Intra STX1A Q16623 RMDN2 Homo sapiens Q96LZ7
Validated Y2H
32296183
Intra STX1A Q16623 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra STX1A Q16623 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
Intra STX1A Q16623 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra STX1A Q16623 FAM3C Homo sapiens Q92520
Validated Y2H
32296183
Intra STX1A Q16623 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra STX1A Q16623 TXLNA Homo sapiens P40222
Y2H Prey Pooling
32296183
Intra STX1A Q16623 TXLNA Homo sapiens P40222
Y2H Array
32296183
Intra STX1A Q16623 TXLNA Homo sapiens P40222
Y2H Array
24722188
Intra STX1A Q16623 NAPB Homo sapiens Q9H115
Y2H Array
32296183
Intra STX1A Q16623 NAPB Homo sapiens Q9H115
Y2H Array
24722188
Intra STX1A Q16623 NAPB Homo sapiens Q9H115
Y2H Prey Pooling
32296183
Intra STX1A Q16623 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra STX1A Q16623 AOC3 Homo sapiens Q16853
Validated Y2H
32296183
Intra STX1A Q16623 APOL2 Homo sapiens Q9BQE5
Validated Y2H
32296183
Intra STX1A Q16623 VSTM4 Homo sapiens Q8IW00
Validated Y2H
32296183
Intra STX1A Q16623 GOSR2 Homo sapiens O14653
Y2H Prey Pooling
32296183
Intra STX1A Q16623 GOSR2 Homo sapiens O14653
Y2H Array
32296183
Intra STX1A Q16623 BLOC1S6 Homo sapiens Q9UL45
Validated Y2H
32296183
Intra STX1A Q16623 SNAP25 Homo sapiens P60880
Y2H Pooling
16169070
Intra STX1A Q16623 AARD Homo sapiens Q4LEZ3
Validated Y2H
32296183
Intra STX1A Q16623 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra STX1A Q16623 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra STX1A Q16623 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra STX1A Q16623 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra STX1A Q16623 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra STX1A Q16623 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra STX1A Q16623 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra STX1A Q16623 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra STX1A Q16623 STX1A Homo sapiens Q16623
Y2H Array
24722188
Intra STX1A Q16623 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra STX1A Q16623 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra STX1A Q16623 DDX49 Homo sapiens Q9Y6V7
Validated Y2H
32296183
Intra STX1A Q16623 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra STX1A Q16623 ZNF440 Homo sapiens Q8IYI8
Validated Y2H
32296183
Intra STX1A Q16623 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra STX1A Q16623 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra STX1A Q16623 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra STX1A Q16623 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra STX1A Q16623 USE1 Homo sapiens Q9NZ43
Validated Y2H
32296183
Intra STX1A Q16623 RAB3IL1 Homo sapiens Q8TBN0
Validated Y2H
32296183
Intra STX1A Q16623 ZNF707 Homo sapiens Q96C28
Validated Y2H
32296183
Intra STX1A Q16623 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra STX1A Q16623 ETNK2 Homo sapiens Q9NVF9
Validated Y2H
32296183
Intra STX1A Q16623 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Intra STX1A Q16623 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
Intra STX1A Q16623 BTN2A2 Homo sapiens Q8WVV5
Validated Y2H
32296183
Intra STX1A Q16623 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra STX1A Q16623 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra STX1A Q16623 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

Acute Diarrhea
Foodborne Botulism

Botulism

Botulism Poisoning

Intoxication With Clostridium Botulinum Toxin

Wound Botulism

Food Poisoning Due To Clostridium Botulinum

Infection Due To Clostridium Botulinum

Infant Botulism

Intoxication Botulism

Botulism, Infantile

Clostridium Botulinum Poisoning

Botulism Nos

Dysentery

Infectious Diarrhea

Campylobacteriosis

Campylobacter Infections

Campylobacter Infection

Enteric Campylobacteriosis

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Shigellosis

Dysentery, Bacillary

Bacillary Dysentery

Shigella Boydii Infectious Disease

Shigella Flexneri Infectious Disease

Shigella Gastroenteritis

Shigella Sonnei Infectious Disease

Shigella Infections

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

3-Methylcrotonyl-Coa Carboxylase 2 Deficiency

MCC2D

Mcc2 Deficiency

3-Methylcrotonyl Coa Carboxylase 2 Deficiency

3-Methylcrotonylglycinuria Ii

Methylcrotonylglycinuria, Type Ii

3-Methylcrotonoyl-Coa Carboxylase 2 Deficiency

3-Methylcrotonylglycinuria Type Ii

Mcgii

Methylcrotonylglycinuria Type Ii

Supravalvular Aortic Stenosis

SVAS

Supravalvar Aortic Stenosis

Supravalvar Aortic Stenosis, Eisenberg Type

Aortic Supravalvular Stenosis

Aortic Stenosis, Supravalvular

Supra-Valvular Aortic Stenosis

Stenosis, Aortic Supravalvular

Stenosis, Supravalvular Aortic

Supravalvular Stenosis, Aortic

Aortic Stenosis Supravalvular

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STX1A VGNC VGNC:78043
Felis catus STX1A VGNC VGNC:65810
Canis familiaris STX1A VGNC VGNC:46954
Bos taurus STX1A VGNC VGNC:35436
Rattus norvegicus STX1A RGD RGD:69430
Mus musculus STX1A MGD MGI:109355