2. Gene
  3. CMTM7 - CKLF like MARVEL transmembrane domain containing 7 Gene

CMTM7 - CKLF like MARVEL transmembrane domain containing 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 CKLF 样 MARVEL 跨膜结构域 7

种属: Homo sapiens

同用名: CKLFSF7

基因 ID: 112616 | 基因类型: protein coding

关于 CMTM7

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,391,853-32,455,528 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 14 paralogues. Broad expression in lymph node (RPKM 7.5), spleen (RPKM 7.1) and 25 other tissues.

功能概要

该基因属于趋化因子样因子基因超家族，这是一个类似于趋化因子和跨膜 4 超家族的新家族。该基因是位于 3 号染色体簇中的几个趋化因子样因子基因之一。该基因作为肿瘤抑制因子调节细胞周期中的 G1/S 转换，以及肿瘤发病过程中的表皮生长因子受体/蛋白激酶 B 信号传导.可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 2 月]

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

CMTM7 基因产物(2)

mRNA Protein Name
NM_138410.4 NP_612419.1 CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
NM_181472.3 NP_852137.1 CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CMTM7 蛋白结构

MARVEL

MARVEL: Membrane-associating domain (41 - 160)

  • 0
  • 100
  • 175 a.a.
蛋白主名 其他名称

CKLF-like MARVEL transmembrane domain-containing protein 7

chemokine-like factor super family 7

CMTM7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CMTM7 Q96FZ5 SHISA3 Homo sapiens A0PJX4
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 SHISA3 Homo sapiens A0PJX4
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 SDC3 Homo sapiens A0A0S2Z4U3
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 SDC3 Homo sapiens A0A0S2Z4U3
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 TMEM174 Homo sapiens Q8WUU8
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TMEM174 Homo sapiens Q8WUU8
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 GGT7 Homo sapiens Q9UJ14
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 GGT7 Homo sapiens Q9UJ14
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 GGT7 Homo sapiens Q9UJ14
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 CLSTN3 Homo sapiens Q9BQT9
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 CLSTN3 Homo sapiens Q9BQT9
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 CLSTN3 Homo sapiens Q9BQT9
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 HIBADH Homo sapiens P31937
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 PIANP Homo sapiens Q8IYJ0
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 PIANP Homo sapiens Q8IYJ0
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 CD74 Homo sapiens P04233-2
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 DAGLA Homo sapiens Q9Y4D2
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 DAGLA Homo sapiens Q9Y4D2
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 DAGLA Homo sapiens Q9Y4D2
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 MS4A4A Homo sapiens Q96JQ5
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 MS4A4A Homo sapiens Q96JQ5
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 MS4A4A Homo sapiens Q96JQ5
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 SLC14A2 Homo sapiens Q15849
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 SLC14A2 Homo sapiens Q15849
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 AGER Homo sapiens Q15109
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 AGER Homo sapiens Q15109
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 HAS3 Homo sapiens O00219-2
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 HAS3 Homo sapiens O00219-2
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 TEX29 Homo sapiens Q8N6K0
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 TEX29 Homo sapiens Q8N6K0
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 PAGE1 Homo sapiens O75459
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 PAGE1 Homo sapiens O75459
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 DNAJC1 Homo sapiens Q96KC8
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 DNAJC1 Homo sapiens Q96KC8
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 DNAJC1 Homo sapiens Q96KC8
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 B3GAT1 Homo sapiens Q9P2W7
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 B3GAT1 Homo sapiens Q9P2W7
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 B3GAT1 Homo sapiens Q9P2W7
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 ADTRP Homo sapiens Q96IZ2
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 ADTRP Homo sapiens Q96IZ2
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 ADTRP Homo sapiens Q96IZ2
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TNFRSF17 Homo sapiens Q02223
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TNFRSF17 Homo sapiens Q02223
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 TCTA Homo sapiens P57738
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TCTA Homo sapiens P57738
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
种属内
CMTM7 Q96FZ5 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 FRMD3 Homo sapiens A2A2Y4
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 FRMD3 Homo sapiens A2A2Y4
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 BIK Homo sapiens Q13323
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 STX1A Homo sapiens Q16623
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
种属内
CMTM7 Q96FZ5 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
种属内
CMTM7 Q96FZ5 CD79A Homo sapiens P11912
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mayer-Rokitansky-Kuster-Hauser Syndrome Type 1

Rokitansky Sequence

Congenital Absence Of Uterus And Vagina

Mrkh Syndrome Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02869 CMTM7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CMTM7 VGNC VGNC:61003
Canis familiaris CMTM7 VGNC VGNC:52872
Mus musculus CMTM7 MGD MGI:2447166
Macaca mulatta CMTM7 VGNC VGNC:71218
Rattus norvegicus CMTM7 RGD RGD:1591926
Bos taurus CMTM7 VGNC VGNC:27487
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