2. Gene
  3. DAGLA - diacylglycerol lipase alpha Gene

DAGLA - diacylglycerol lipase alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二酰甘油脂肪酶α

种属: Homo sapiens

同用名: NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA)

基因 ID: 747 | 基因类型: protein coding

关于 DAGLA

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,680,391-61,747,001 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 3 paralogues. Broad expression in brain (RPKM 6.7), colon (RPKM 2.0) and 20 other tissues.

功能概要

该基因编码二酰甘油脂肪酶。编码的酶参与内源性大麻素 2-花生四烯酰-甘油的生物合成。[RefSeq 提供，2010 年 11 月]

This gene encodes a diacylglycerol Lipase. The encoded Enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]

DAGLA 基因产物(1)

mRNA Protein Name
NM_006133.3 NP_006124.1 diacylglycerol lipase-alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23502535 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in arachidonate metabolic process IDA
IDA: 通过直接分析推断
14610053 GOA
involved in diacylglycerol catabolic process IDA
IDA: 通过直接分析推断
14610053 GOA
involved in diacylglycerol catabolic process IMP
IMP: 通过突变表型推断
23502535 GOA
involved in retrograde trans-synaptic signaling by endocannabinoid IMP
IMP: 通过突变表型推断
23502535 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite membrane IDA
IDA: 通过直接分析推断
27595600 GOA
located in early endosome membrane IDA
IDA: 通过直接分析推断
27595600 GOA
located in postsynaptic density membrane IDA
IDA: 通过直接分析推断
27595600 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAGLA 蛋白结构

Lipase_3

Lipase_3: Lipase (class 3) (394 - 529)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1042 a.a.
蛋白主名 其他名称

diacylglycerol lipase-alpha

DAGL-alpha

DAGLA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DAGLA Q9Y4D2 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra DAGLA Q9Y4D2 STOM Homo sapiens P27105
Y2H Array
32296183
Intra DAGLA Q9Y4D2 UPK1B Homo sapiens O75841
Y2H Array
32296183
Intra DAGLA Q9Y4D2 UPK1B Homo sapiens O75841
Y2H Prey Pooling
32296183
Intra DAGLA Q9Y4D2 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra DAGLA Q9Y4D2 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 20

Spinocerebellar Ataxia Type 20

SCA20

Spinocerebellar Ataxia With Dysphonia

Spinocerebellar Ataxia With Spasmodic Cough

Chromosome 11q12 Duplication Syndrome, 260-Kb

Chromosome 11q12 Duplication Syndrome 260-Kb
Spasmodic Dysphonia

Adductor Spasmodic Dysphonia

Laryngeal Dystonia

Spastic Dysphonia

Abductor Spasmodic Dysphonia

Laryngeal Dyskinesia

Mixed Spasmodic Dysphonia

Abductor Spastic Dysphonia

Adductor Spastic Dysphonia
Cannabis Abuse

Marijuana Abuse
Cannabis Dependence

Marijuana Abuse

Cannabinoid Addiction

Cannabinoid Dependence

Cannabis Addiction
Hallucinogen Dependence

Hallucinogen Addiction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P4406 Abz-AGLA-Nba / 否
HY-RS03520 DAGLA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DAGLA MGD MGI:2677061
Bos taurus DAGLA VGNC VGNC:27872
Canis familiaris DAGLA VGNC VGNC:39764
Rattus norvegicus DAGLA RGD RGD:1359461
Felis catus DAGLA VGNC VGNC:61332
Macaca mulatta DAGLA VGNC VGNC:107444
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