1. Gene
  2. CLSTN3 - calsyntenin 3 Gene

CLSTN3 - calsyntenin 3 Gene

中文名称:钙调蛋白 3

种属: Homo sapiens

同用名: CSTN3; CDHR14; alcbeta

基因 ID: 9746 | 基因类型: protein coding

关于 CLSTN3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,129,093-7,158,945 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 203 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 35.5), kidney (RPKM 13.1) and 23 other tissues.

功能概要

预测可启用钙离子结合活性。预计参与突触组装的正向调控和突触传递的正向调控。预计在几个过程的上游或内部起作用,包括化学突触传递;蛋白质定位到突触的正向调节;和突触组装。预测位于突触后密度。预计是含蛋白质复合物的一部分。预计在几种细胞成分中具有活性,包括 GABA 能突触;谷氨酸能突触;和突触后膜。预计是突触后密度膜的组成部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of synapse assembly and positive regulation of synaptic transmission. Predicted to act upstream of or within several processes, including chemical synaptic transmission; positive regulation of protein localization to synapse; and synapse assembly. Predicted to be located in postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

CLSTN3 基因产物(1)

mRNA Protein Name
NM_014718.4 NP_055533.2 calsyntenin-3 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell-cell adhesion mediator activity IDA
IDA: 通过直接分析推断
33101212 GOA
enables neurexin family protein binding IDA
IDA: 通过直接分析推断
33101212 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-ascorbic acid metabolic process IDA
IDA: 通过直接分析推断
34673103 GOA
involved in regulation of synapse assembly IDA
IDA: 通过直接分析推断
33101212 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CLSTN3 蛋白结构

Laminin_G_3

Laminin_G_3: Concanavalin A-like lectin/glucanases superfamily (361 - 541)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 956 a.a.
蛋白主名 其他名称

calsyntenin-3

alc-beta

CLSTN3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CLSTN3 Q9BQT9 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vertebral Artery Occlusion

Occlusion And Stenosis Of Vertebral Artery

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CLSTN3 VGNC VGNC:60981
Canis familiaris CLSTN3 VGNC VGNC:39364
Bos taurus CLSTN3 VGNC VGNC:27468
Macaca mulatta CLSTN3 VGNC VGNC:71203
Rattus norvegicus CLSTN3 RGD RGD:621153
Mus musculus CLSTN3 MGD MGI:2178323