2. Gene
  3. MS4A4A - membrane spanning 4-domains A4A Gene

MS4A4A - membrane spanning 4-domains A4A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜 4 域 A4A

种属: Homo sapiens

同用名: MS4A4; MS4A7; 4SPAN1; CD20L1; CD20-L1; HDCME31P

基因 ID: 51338 | 基因类型: protein coding

关于 MS4A4A

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,280,666-60,308,970 (from NCBI)

This gene has 18 transcripts (splice variants), 118 orthologues and 16 paralogues. Broad expression in placenta (RPKM 28.4), gall bladder (RPKM 18.9) and 20 other tissues.

功能概要

该基因编码跨膜 4A 基因家族的成员。这个新生蛋白家族的成员具有共同的结构特征、相似的内含子/外显子剪接边界，并在造血细胞和非淋巴组织中表现出独特的表达模式。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

MS4A4A 基因产物(3)

mRNA Protein Name
NM_001243266.2 NP_001230195.1 membrane-spanning 4-domains subfamily A member 4A isoform 3
NM_024021.4 NP_076926.2 membrane-spanning 4-domains subfamily A member 4A isoform 2
NM_148975.3 NP_683876.1 membrane-spanning 4-domains subfamily A member 4A isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
30833792 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
31413141 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
31413141 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
23874341 GOA
located in plasma membrane raft IDA
IDA: 通过直接分析推断
31413141 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MS4A4A 蛋白结构

CD20

CD20: CD20-like family (65 - 207)

  • 0
  • 100
  • 200
  • 239 a.a.
蛋白主名 其他名称

membrane-spanning 4-domains subfamily A member 4A

CD20 antigen-like 1

MS4A4A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MS4A4A Q96JQ5 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra MS4A4A Q96JQ5 RPRM Homo sapiens Q9NS64
Complementation
32296183
Intra MS4A4A Q96JQ5 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra MS4A4A Q96JQ5 NRG1 Homo sapiens Q02297-10
Y2H Array
32296183
Intra MS4A4A Q96JQ5 NRG1 Homo sapiens Q02297-10
Y2H Prey Pooling
32296183
Intra MS4A4A Q96JQ5 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra MS4A4A Q96JQ5 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra MS4A4A Q96JQ5 CSE1L Homo sapiens P55060
Pull Down
30833792
Intra MS4A4A Q96JQ5 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra MS4A4A Q96JQ5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra MS4A4A Q96JQ5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra MS4A4A Q96JQ5 SEC22A Homo sapiens Q96IW7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alzheimer Disease 4

AD4

Alzheimer Disease-4

Alzheimer'S Disease 4

Alzheimer Disease, Familial, 4

Alzheimer Disease, Familial4

Alzheimer'S Disease 4, Early Onset

Alzheimer Disease, Type 4
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08702 MS4A4A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MS4A4A VGNC VGNC:104706
Rattus norvegicus MS4A4A RGD RGD:1307006
Mus musculus MS4A4A MGD MGI:3643932
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