CSE1L - chromosome segregation 1 like Gene

中文名称：染色体分离 1 样

种属: Homo sapiens

同用名: CAS; CSE1; XPO2

关于 CSE1L

功能概要

携带核定位信号 (NLS) 的蛋白质通过输入蛋白-α/β 异二聚体转运到细胞核中。 Importin-alpha 结合 NLS，而 importin-beta 通过核孔复合体介导易位。易位后，RanGTP 结合 importin-beta 并取代 importin-alpha。然后必须将 Importin-alpha 返回细胞质，留下 NLS 蛋白。该基因编码的蛋白质与无 NLS 的 importin-alpha 强烈结合，这种结合通过 RANBP1 和 RANGAP1 的联合作用在细胞质中释放。此外，编码的蛋白质可能在细胞凋亡和细胞增殖中发挥作用。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 1 月]

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in Apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]