P2RY6 - pyrimidinergic receptor P2Y6 Gene

中文名称：嘧啶能受体 P2Y6

种属: Homo sapiens

同用名: P2Y6

关于 P2RY6

功能概要

该基因的产物属于 P2 受体家族，由细胞外核苷酸激活，细分为 P2X 配体门控离子通道和 P2Y G 蛋白偶联受体。该家族有几种具有不同药理学选择性的受体亚型，在某些情况下，它们对各种腺苷和尿苷核苷酸有重叠。该受体是一种 G 蛋白偶联受体，对 UDP 有反应，对 UTP 和 ADP 有部分反应，对 ATP 没有反应。有人提出该受体介导炎症反应。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供，2013 年 3 月]

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]