2. Gene
  3. PLSCR1 - phospholipid scramblase 1 Gene

PLSCR1 - phospholipid scramblase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂加扰酶 1

种属: Homo sapiens

同用名: MMTRA1B

基因 ID: 5359 | 基因类型: protein coding

关于 PLSCR1

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:146,515,180-146,544,607 (from NCBI)

This gene has 19 transcripts (splice variants), 235 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 43.5), gall bladder (RPKM 33.7) and 25 other tissues.

功能概要

该基因编码磷脂加扰酶家族成员。编码的蛋白质参与破坏磷脂在质膜内外小叶之间的不对称分布，导致磷脂酰丝氨酸外化。这种细胞膜破坏在血液凝固级联反应以及凋亡细胞的巨噬细胞清除中起着重要作用。编码的蛋白质还与基因调控和干扰素诱导的抗病毒反应有关。[RefSeq 提供，2022 年 5 月]

This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of Phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced Antiviral responses. [provided by RefSeq, May 2022]

PLSCR1 基因产物(13)

mRNA Protein Name
NM_001363872.1 NP_001350801.1 phospholipid scramblase 1 isoform 2
NM_001363874.1 NP_001350803.1 phospholipid scramblase 1 isoform 3
NM_001406033.1 NP_001392962.1 phospholipid scramblase 1 isoform 4
NM_001406034.1 NP_001392963.1 phospholipid scramblase 1 isoform 1
NM_001406035.1 NP_001392964.1 phospholipid scramblase 1 isoform 1
NM_001406036.1 NP_001392965.1 phospholipid scramblase 1 isoform 5
NM_001406037.1 NP_001392966.1 phospholipid scramblase 1 isoform 6
NM_001406038.1 NP_001392967.1 phospholipid scramblase 1 isoform 3
NM_001406039.1 NP_001392968.1 phospholipid scramblase 1 isoform 3
NM_001406040.1 NP_001392969.1 phospholipid scramblase 1 isoform 3
NM_001406041.1 NP_001392970.1 phospholipid scramblase 1 isoform 3
NM_001406042.1 NP_001392971.1 phospholipid scramblase 1 isoform 7
NM_021105.3 NP_066928.1 phospholipid scramblase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CD4 receptor binding IPI
IPI: 通过物理相互作用推断
19333378 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16091359 GOA
enables SH3 domain binding IDA
IDA: 通过直接分析推断
11390389 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
8663431 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
12586838 GOA
enables epidermal growth factor receptor binding IPI
IPI: 通过物理相互作用推断
12009895 GOA
enables lead ion binding IDA
IDA: 通过直接分析推断
23659204 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
27206388 GOA
enables mercury ion binding IDA
IDA: 通过直接分析推断
23659204 GOA
enables nuclease activity IMP
IMP: 通过突变表型推断
27206388 GOA
enables phospholipid scramblase activity IDA
IDA: 通过直接分析推断
8663431 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables virus receptor activity IMP
IMP: 通过突变表型推断
21806988 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
27206388 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic process IDA
IDA: 通过直接分析推断
10770950 GOA
involved in defense response to virus IMP
IMP: 通过突变表型推断
15308695 GOA
involved in negative regulation of phagocytosis IMP
IMP: 通过突变表型推断
26745724 GOA
involved in negative regulation of viral genome replication IMP
IMP: 通过突变表型推断
15308695 GOA
involved in phosphatidylserine exposure on apoptotic cell surface IMP
IMP: 通过突变表型推断
32110987 GOA
involved in plasma membrane phospholipid scrambling IDA
IDA: 通过直接分析推断
9218461 GOA
involved in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IDA
IDA: 通过直接分析推断
17567603 GOA
involved in positive regulation of chromosome separation IDA
IDA: 通过直接分析推断
27206388 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
15308695 GOA
involved in positive regulation of innate immune response IMP
IMP: 通过突变表型推断
15308695 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16091359 GOA
involved in response to interferon-beta IMP
IMP: 通过突变表型推断
15308695 GOA
involved in response to lead ion IDA
IDA: 通过直接分析推断
29748552 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
12586838 GOA
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
20870722 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22052202 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17712045 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
12009895 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
17567603 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12564925 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
22052202 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9218461 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLSCR1 蛋白结构

Scramblase

Scramblase: Scramblase (86 - 306)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
蛋白主名 其他名称

phospholipid scramblase 1

PL scramblase 1

PLSCR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLSCR1 O15162 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
种属内
PLSCR1 O15162 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
25416956
种属内
PLSCR1 O15162 BCL6B Homo sapiens A8KA13
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 KRTAP10-11 Homo sapiens P60412
Validated Y2H
25416956
种属内
PLSCR1 O15162 P2RY6 Homo sapiens Q15077
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 P2RY6 Homo sapiens Q15077
Y2H Array
25416956
种属内
PLSCR1 O15162 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 LCE2D Homo sapiens Q5TA82
Y2H Array
25416956
种属内
PLSCR1 O15162 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
25416956
种属内
PLSCR1 O15162 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
25416956
种属内
PLSCR1 O15162 GDPD5 Homo sapiens Q9HBR3
Y2H Array
25416956
种属内
PLSCR1 O15162 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
种属内
PLSCR1 O15162 NUFIP2 Homo sapiens Q7Z417
Anti Tag CoIP
21653829
种属内
PLSCR1 O15162 NUFIP2 Homo sapiens Q7Z417
Y2H Pooling
21653829
种属间
PLSCR1 O15162 yscY Yersinia pestis P61417
Y2H Array
21911467
种属间
PLSCR1 O15162 yscB Yersinia pestis Q56973
Y2H Array
21911467
种属间
PLSCR1 O15162 ompA Yersinia pestis Q8ZG77
Y2H Array
21911467
种属内
PLSCR1 O15162 RGS3 Homo sapiens P49796
Validated Y2H
25416956
种属内
PLSCR1 O15162 RGS3 Homo sapiens P49796
Y2H Array
25416956
种属内
PLSCR1 O15162 RGS3 Homo sapiens P49796
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 VPS37C Homo sapiens A5D8V6
Validated Y2H
25416956
种属内
PLSCR1 O15162 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
25416956
种属间
PLSCR1 O15162 yscK Yersinia pestis P69974
Y2H Array
21911467
种属内
PLSCR1 O15162 OCLN Homo sapiens Q16625
Anti Tag CoIP
21806988
种属内
PLSCR1 O15162 SMARCC1 Homo sapiens Q92922
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 TFG Homo sapiens Q92734
Y2H Pooling
16189514
种属内
PLSCR1 O15162 CPSF6 Homo sapiens Q16630
Y2H Pooling
16189514
种属内
PLSCR1 O15162 GLRX3 Homo sapiens O76003
Validated Y2H
25416956
种属内
PLSCR1 O15162 GLRX3 Homo sapiens O76003
Y2H Pooling
16189514
种属内
PLSCR1 O15162 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
种属间
PLSCR1 O15162 Hoxa1 Mus musculus P09022
BiFC
23088713
种属间
PLSCR1 O15162 Hoxa1 Mus musculus P09022
Pull Down
23088713
种属内
PLSCR1 O15162 DOCK2 Homo sapiens Q92608
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
25416956
种属内
PLSCR1 O15162 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 DAZAP2 Homo sapiens Q15038
Validated Y2H
25416956
种属内
PLSCR1 O15162 DAZAP2 Homo sapiens Q15038
Y2H Pooling
16189514
种属内
PLSCR1 O15162 FRS3 Homo sapiens O43559
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 EWSR1 Homo sapiens Q01844
Y2H Array
25416956
种属内
PLSCR1 O15162 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
25416956
种属内
PLSCR1 O15162 PRR13 Homo sapiens Q9NZ81
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 PRR13 Homo sapiens Q9NZ81
Validated Y2H
25416956
种属内
PLSCR1 O15162 PRR13 Homo sapiens Q9NZ81
Y2H Array
25416956
种属内
PLSCR1 O15162 ILF3 Homo sapiens Q9NXX0
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 ILF3 Homo sapiens Q9NXX0
Validated Y2H
25416956
种属内
PLSCR1 O15162 CATSPER1 Homo sapiens Q8NEC5
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 CATSPER1 Homo sapiens Q8NEC5
Y2H Array
25416956
种属内
PLSCR1 O15162 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
25416956
种属内
PLSCR1 O15162 DEF6 Homo sapiens Q9H4E7
Validated Y2H
25416956
种属内
PLSCR1 O15162 DEF6 Homo sapiens Q9H4E7
Y2H Array
25416956
种属内
PLSCR1 O15162 DEF6 Homo sapiens Q9H4E7
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 NEU4 Homo sapiens Q8WWR8
Y2H Pooling
16189514
种属内
PLSCR1 O15162 SCNM1 Homo sapiens Q9BWG6
Y2H Array
31515488
种属内
PLSCR1 O15162 SCNM1 Homo sapiens Q9BWG6
Y2H Array
25416956
种属内
PLSCR1 O15162 STK16 Homo sapiens O75716
Validated Y2H
25416956
种属内
PLSCR1 O15162 STK16 Homo sapiens O75716
Y2H Array
25416956
种属内
PLSCR1 O15162 APP Homo sapiens P05067
Y2H Pooling
32814053
种属内
PLSCR1 O15162 APP Homo sapiens P05067
Validated Y2H
32814053
种属内
PLSCR1 O15162 APP Homo sapiens P05067
Y2H Array
32814053
种属内
PLSCR1 O15162 PKD2 Homo sapiens Q13563
Validated Y2H
25416956
种属内
PLSCR1 O15162 PKD2 Homo sapiens Q13563
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 ESR2 Homo sapiens Q92731
Validated Y2H
25416956
种属内
PLSCR1 O15162 SPATA8 Homo sapiens Q6RVD6
Y2H Array
25416956
种属内
PLSCR1 O15162 SPATA8 Homo sapiens Q6RVD6
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 CTSZ Homo sapiens Q9UBR2
Y2H Array
25416956
种属内
PLSCR1 O15162 CTSZ Homo sapiens Q9UBR2
Y2H Prey Pooling
25416956
种属内
PLSCR1 O15162 LGALS9C Homo sapiens Q6DKI2
Y2H Array
25416956
种属内
PLSCR1 O15162 LGALS9C Homo sapiens Q6DKI2
Validated Y2H
25416956
种属内
PLSCR1 O15162 CHRD Homo sapiens Q9H2X0
Validated Y2H
25416956
种属内
PLSCR1 O15162 CHRD Homo sapiens Q9H2X0
Y2H Array
25416956
种属内
PLSCR1 O15162 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
25416956
种属内
PLSCR1 O15162 DMRT3 Homo sapiens Q9NQL9
Y2H Array
25416956
种属间
PLSCR1 O15162 polg_hcvco Hepatitis C virus Q9WMX2
Anti Tag CoIP
21806988
种属间
PLSCR1 O15162 polg_hcvco Hepatitis C virus Q9WMX2
Y2H
21806988
种属间
PLSCR1 O15162 polg_hcvco Hepatitis C virus Q9WMX2
Pull Down
21806988
种属间: 跨种属相互作用 种属内: 同种属相互作用

PLSCR1 抗体

目录号 产品名 应用 反应物种
HY-P82674 Scramblase 1 Antibody (YA2419) WB, ICC/IF, IP, FC Human

关联疾病

疾病名称 别名
Scott Syndrome

SCTS

Bdplt7

Prothrombin Consumption Deficiency

Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X

Bleeding Disorder, Platelet-Type, 7

Prothrombin Conversion Defect, Familial

Prothrombin Consumption Inhibitor, Familial

Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X

Familial Prothrombin Consumption Inhibitor

Familial Prothrombin Conversion Defect

Platelet-Type Bleeding Disorder 7

Platelet Factor X Receptor Deficiency

Bleeding Disorder Platelet-Type 7

Prothrombin Consumption Inhibitor Familial

Prothrombin Conversion Defect Familial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10741 PLSCR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLSCR1 RGD RGD:620521
Mus musculus PLSCR1 MGD MGI:893575
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