CPSF6 - cleavage and polyadenylation specific factor 6 Gene

中文名称：切割和聚腺苷酸化特异性因子 6

种属: Homo sapiens

同用名: CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7

基因 ID: 11052 | 基因类型: protein coding

关于 CPSF6

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,239,569-69,274,358 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.3), lymph node (RPKM 15.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是 3' RNA 切割和聚腺苷酸化加工所需的切割因子的一个亚基。蛋白质与 RNA 的相互作用是组装 3' 端加工复合物的最早步骤之一，并促进其他加工因子的募集。切割因子复合物由四种多肽组成。该基因编码 68kD 亚基。它具有让人联想到剪接体蛋白的域组织。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

CPSF6 基因产物(2)

mRNA	Protein	Name
NM_001300947.2	NP_001287876.1	cleavage and polyadenylation specificity factor subunit 6 isoform 2
NM_007007.3	NP_008938.2	cleavage and polyadenylation specificity factor subunit 6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to RNA binding	IDA IDA: 通过直接分析推断	15169763	GOA
enables exon-exon junction complex binding	IDA IDA: 通过直接分析推断	19864460	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	21295486	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14561889	GOA
enables ribosomal large subunit binding	IDA IDA: 通过直接分析推断	19864460	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IDA IDA: 通过直接分析推断	29276085	GOA
involved in mRNA 3'-end processing	IDA IDA: 通过直接分析推断	20695905	GOA
involved in mRNA alternative polyadenylation	IMP IMP: 通过突变表型推断	20695905	GOA
involved in mRNA processing	IDA IDA: 通过直接分析推断	14690600	GOA
involved in positive regulation of RNA export from nucleus	IMP IMP: 通过突变表型推断	19864460	GOA
involved in protein heterotetramerization	IDA IDA: 通过直接分析推断	23187700	GOA
involved in protein tetramerization	IDA IDA: 通过直接分析推断	20695905	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	19864460	GOA
located in interchromatin granule	IDA IDA: 通过直接分析推断	17267687	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: 通过直接分析推断	23187700	GOA
part of mRNA cleavage factor complex	IDA IDA: 通过直接分析推断	9659921	GOA
part of mRNA cleavage factor complex	IPI IPI: 通过物理相互作用推断	21295486	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	17267687	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	17267687	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19864460	GOA
located in paraspeckles	IDA IDA: 通过直接分析推断	9659921	GOA
located in perichromatin fibrils	IDA IDA: 通过直接分析推断	17267687	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	18809582	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPSF6 蛋白结构

0
100
200
300
400
500
551 a.a.

蛋白主名

其他名称

cleavage and polyadenylation specificity factor subunit 6

CPSF 68 kDa subunit

CPSF6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CPSF6	Q16630	TOLLIP	Homo sapiens	Q6FIE9	Y2H Prey Pooling	25416956
Intra	CPSF6	Q16630	PPIL1	Homo sapiens	Q9Y3C6	Y2H Array	25416956
Intra	CPSF6	Q16630	PPIL1	Homo sapiens	Q9Y3C6	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Anti Tag CoIP	33961781
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Pull Down	22960638
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Anti Bait CoIP	22960638
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Pull Down	35177536
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	PLSCR1	Homo sapiens	O15162	Pull Down	16189514
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Anti Tag CoIP	33961781
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Y2H Pooling	16189514
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Y2H Pooling	19447967
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	ARMC7	Homo sapiens	Q9H6L4	Y2H Pooling	16189514
Intra	CPSF6	Q16630	WWP2	Homo sapiens	O00308	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	WWP2	Homo sapiens	O00308	Y2H Pooling	16189514
Intra	CPSF6	Q16630	OTUB2	Homo sapiens	Q96DC9	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Carnitine-Acylcarnitine Translocase Deficiency

Cact Deficiency	Carnitine Acylcarnitine Translocase Deficiency
CACTD	Carnitine-Acylcarnitine Carrier Deficiency

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-120072	PF-3450074	Inhibitor	98.44%	否
HY-RS03120	CPSF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CPSF6	VGNC	VGNC:61144
Mus musculus	CPSF6	MGD	MGI:1913948
Macaca mulatta	CPSF6	VGNC	VGNC:71401
Bos taurus	CPSF6	VGNC	VGNC:27674
Canis familiaris	CPSF6	VGNC	VGNC:39577
Rattus norvegicus	CPSF6	RGD	RGD:1304640

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CPSF6 - cleavage and polyadenylation specific factor 6 Gene

关于 CPSF6

功能概要

CPSF6 基因产物(2)

CPSF6 蛋白结构

CPSF6 蛋白互作信息

关联疾病

直系同源

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CPSF6 - cleavage and polyadenylation specific factor 6 Gene

关于 CPSF6

功能概要

CPSF6 基因产物(2)

CPSF6 蛋白结构

CPSF6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z