WWP1 - WW domain containing E3 ubiquitin protein ligase 1 Gene

中文名称：含 WW 结构域的 E3 泛素蛋白连接酶 1

种属: Homo sapiens

同用名: AIP5; Tiul1; hSDRP1

关于 WWP1

功能概要

含有 WW 结构域的蛋白质存在于所有真核生物中，并且在调节多种细胞功能 (例如蛋白质降解、转录和 RNA 剪接) 中发挥重要作用。该基因编码的蛋白质包含 4 个串联 WW 结构域和一个 HECT (与 E6 相关蛋白羧基末端同源) 结构域。编码的蛋白质属于 NEDD4 样蛋白质家族，它们是 E3 泛素连接酶分子，调节关键的运输决策，包括将蛋白质靶向蛋白体或溶酶体。该基因的可变剪接产生至少 6 个转录变体；然而，这些转录本的全长性质尚未确定。[RefSeq 提供，2008 年 7 月]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]