2. Gene
  3. ARRDC1 - arrestin domain containing 1 Gene

ARRDC1 - arrestin domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含抑制域 1

种属: Homo sapiens

基因 ID: 92714 | 基因类型: protein coding

关于 ARRDC1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,605,686-137,615,360 (from NCBI)

This gene has 12 transcripts (splice variants), 225 orthologues and 5 paralogues. Ubiquitous expression in stomach (RPKM 15.2), spleen (RPKM 13.5) and 25 other tissues.

功能概要

启用多种功能，包括抑制蛋白家族蛋白结合活性；泛素连接酶-底物衔接活性；和泛素蛋白连接酶结合活性。参与多个过程，包括细胞蛋白质代谢过程；细胞外囊泡生物发生； Notch 信号通路的负调控。位于细胞质囊泡中；细胞外囊泡；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular protein metabolic process; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARRDC1 基因产物(2)

mRNA Protein Name
NM_001317968.2 NP_001304897.1 arrestin domain-containing protein 1 isoform 2
NM_152285.4 NP_689498.1 arrestin domain-containing protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arrestin family protein binding IPI
IPI: 通过物理相互作用推断
23886940 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22315426 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22315426 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
22315426 GOA
enables ubiquitin-like ligase-substrate adaptor activity IMP
IMP: 通过突变表型推断
27462458 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in extracellular transport IMP
IMP: 通过突变表型推断
22315426 GOA
involved in extracellular vesicle biogenesis IMP
IMP: 通过突变表型推断
27462458 GOA
involved in negative regulation of Notch signaling pathway IMP
IMP: 通过突变表型推断
23886940 GOA
involved in protein transport IMP
IMP: 通过突变表型推断
27462458 GOA
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
27462458 GOA
NOT involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
27462458 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
23886940 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
23236378 GOA
NOT located in extracellular exosome IDA
IDA: 通过直接分析推断
22315426 GOA
located in extracellular vesicle IDA
IDA: 通过直接分析推断
22315426 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22315426 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARRDC1 蛋白结构

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (7 - 139)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (163 - 284)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
蛋白主名 其他名称

arrestin domain-containing protein 1

alpha-arrestin 1

ARRDC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARRDC1 Q8N5I2 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra ARRDC1 Q8N5I2 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra ARRDC1 Q8N5I2 ITCH Homo sapiens Q96J02
Anti Tag CoIP
38270169
Intra ARRDC1 Q8N5I2 ITCH Homo sapiens Q96J02
Anti Tag CoIP
33961781
Intra ARRDC1 Q8N5I2 ITCH Homo sapiens Q96J02
Anti Tag CoIP
28514442
Intra ARRDC1 Q8N5I2 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra ARRDC1 Q8N5I2 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra ARRDC1 Q8N5I2 KLHL12 Homo sapiens Q53G59
Anti Tag CoIP
38270169
Intra ARRDC1 Q8N5I2 WWP1 Homo sapiens Q9H0M0
Anti Tag CoIP
38270169
Intra ARRDC1 Q8N5I2 WWP1 Homo sapiens Q9H0M0
Validated Y2H
32296183
Intra ARRDC1 Q8N5I2 WWP1 Homo sapiens Q9H0M0
Y2H Prey Pooling
32296183
Intra ARRDC1 Q8N5I2 WWP1 Homo sapiens Q9H0M0
Y2H Array
32296183
Intra ARRDC1 Q8N5I2 WWP2 Homo sapiens O00308
Anti Tag CoIP
38270169
Intra ARRDC1 Q8N5I2 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra ARRDC1 Q8N5I2 WWP2 Homo sapiens O00308
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Methemoglobinemia And Ambiguous Genitalia

METAG

Methemoglobinemia Type Iv

Isolated 17,20-Lyase Deficiency, Pure

Methemoglobinemia Due To Deficiency Of Cytochrome B5

Methemoglobinemia Type 4

Methemoglobinemia Type Iv, Formerly

Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

Pure Isolated 17,20-Lyase Deficiency

Methemoglobinemia, Type Iv
Kleefstra Syndrome 1

9q Subtelomeric Deletion Syndrome

KLEFS1

Chromosome 9q34.3 Deletion Syndrome

9q- Syndrome

9q34 Deletion Syndrome

Kleefstra Syndrome Due To 9q34 Microdeletion

Kleefstra Syndrome

9q-Syndrome

9qstds

Kleefstra Syndrome Due To 9q Subtelomeric Deletion

Kleefstra Syndrome Due To Del(9)(Q34)

Kleefstra Syndrome Due To Monosomy 9q34

Chromosome 9q Subtelomeric Deletion Syndrome

Kleefstra Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01030 ARRDC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ARRDC1 VGNC VGNC:26171
Mus musculus ARRDC1 MGD MGI:2446136
Felis catus ARRDC1 VGNC VGNC:59943
Canis familiaris ARRDC1 VGNC VGNC:38138
Rattus norvegicus ARRDC1 RGD RGD:1309961
Macaca mulatta ARRDC1 VGNC VGNC:69920
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