RGS3 - regulator of G protein signaling 3 Gene

中文名称：G 蛋白信号调节器 3

种属: Homo sapiens

同用名: C2PA; RGP3

关于 RGS3

功能概要

该基因编码 G 蛋白信号转导 (RGS) 家族的一个成员。该蛋白是一种 GTP 酶激活蛋白，可抑制 G 蛋白介导的信号转导。可变剪接和替代启动子的使用导致编码不同亚型的多个转录变体。长亚型主要与细胞溶质和质膜相关，与 Wnt 信号传导和上皮间充质转化中的功能相关，而较短的 N 末端截短亚型可以是核亚型。[RefSeq 提供，2013 年 1 月]

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]