NEU4 - neuraminidase 4 Gene

中文名称：神经氨酸酶 4

种属: Homo sapiens

基因 ID: 129807 | 基因类型: protein coding

关于 NEU4

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,809,193-241,817,413 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 179 orthologues and 3 paralogues. Biased expression in colon (RPKM 9.5), liver (RPKM 4.5) and 5 other tissues.

功能概要

该基因编码的蛋白质属于糖水解酶家族，可从糖蛋白、糖脂、寡糖和神经节苷脂等各种唾液酸衍生物中去除末端唾液酸残基。已经注意到该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2009 年 11 月]

The protein encoded by this gene belongs to a family of glycohydrolytic Enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]

NEU4 基因产物(5)

mRNA	Protein	Name
NM_001167599.3	NP_001161071.1	sialidase-4 isoform 2
NM_001167600.3	NP_001161072.1	sialidase-4 isoform 3
NM_001167601.3	NP_001161073.1	sialidase-4 isoform 3
NM_001167602.3	NP_001161074.1	sialidase-4 isoform 3
NM_080741.4	NP_542779.2	sialidase-4 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables exo-alpha-sialidase activity	IDA IDA: 通过直接分析推断	14962670	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ganglioside catabolic process	IDA IDA: 通过直接分析推断	15213228	GOA
involved in glycoprotein catabolic process	IDA IDA: 通过直接分析推断	15213228	GOA
involved in oligosaccharide catabolic process	IDA IDA: 通过直接分析推断	15213228	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	15847605	GOA
NOT located in lysosome	IDA IDA: 通过直接分析推断	14962670	GOA
located in lysosome	IDA IDA: 通过直接分析推断	15213228	GOA
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	15847605	GOA
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	15847605	GOA
located in organelle inner membrane	IDA IDA: 通过直接分析推断	14962670	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEU4 蛋白结构

BNR_2

0
100
200
300
400
484 a.a.

蛋白主名

其他名称

sialidase-4

N-acetyl-alpha-neuraminidase 4

NEU4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NEU4	Q8WWR8	MDFI	Homo sapiens	Q99750	Y2H	21516116
种属内	NEU4	Q8WWR8	PLSCR1	Homo sapiens	O15162	Pull Down	16189514

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Charcot-Marie-Tooth Disease, Axonal, Type 2v

CMT2V	Charcot-Marie-Tooth Disease Axonal Type 2v
Charcot-Marie-Tooth Neuropathy, Type 2v	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2v
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2v	Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2v
Charcot-Marie-Tooth Neuropathy Type 2v	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Naglu Mutation
Hereditary Adult-Onset Painful Axonal Polyneuropathy	Charcot-Marie-Tooth Disease 2v

Galactosialidosis

Goldberg Syndrome	Neuraminidase Deficiency With Beta-Galactosidase Deficiency
Ppca Deficiency	GSL
Lysosomal Protective Protein Deficiency	Cathepsin A Deficiency
Neuraminidase/Beta-Galactosidase Expression	Protective Protein/Cathepsin A Deficiency
Ngbe	Cathepsin A Deficiency Of
Lysosomal Protective Protein Deficiency Of	Deficiency Of Cathepsin A
Neuraminidase Beta-Galactosidase Deficiency	Protective Protein Cathepsin A Deficiency

Glycoproteinosis

Sialidosis	Mucolipidosis Type I
Mucolipidoses	Cherry Red Spot Myoclonus Syndrome
Mucolipidosis I	Myoclonus Cherry Red Spot Syndrome
Type I Mucolipidosis	Lipomucopolysaccharidosis
Disorders Of Glycoprotein Metabolism	Glycoprotein Storage Disorder

Gm2-Gangliosidosis, Ab Variant

Hexosaminidase Activator Deficiency	Tay-Sachs Disease, Ab Variant
Gm2 Gangliosidosis, Ab Variant	Gm2 Activator Deficiency
Tay-Sachs Disease, Variant Ab	Tay-Sachs Disease Ab Variant
Ab Variant Gm2-Gangliosidosis	Tay-Sachs Variant Ab
Ab Variant	Activator Deficiency/Gm2 Gangliosidosis
Activator-Deficient Tay-Sachs Disease	Gm2 Activator Deficiency Disease
Gm2 Gangliosidosis, Type Ab	Gm2-Gangliosidosis Ab
GM2GAB	Gm2-Gangliosidosis Ab Variant
Gangliosidosis Gm2 Ab Variant	Gm2-Gangliosidosis, Variant Ab

Mucolipidosis

Hurler Syndrome

Mucopolysaccharidosis Ih	Mucopolysaccharidosis Type Ih
Mps1-H	MPS1H
Hurler Disease	Mpsih
Mucopolysaccharidosis Type 1h	Alpha-L-Iduronidase Deficiency
Dysostosis Multiplex	Dysostosis Multiplex Syndrome
Gargoylism	Hurler Disease Mps Type 1h
Hurler-Pfaundler Syndrome	L-Iduronidase Deficiency, Hurler Type
Mucopolysaccharidosis Type I Severe Form	Mucopolysaccharidosis 1h
Hurler'S Syndrome	Mps Ih
Mps-Ih	Pfaundler-Hurler Syndrome
Mucopolysaccharidosis I

Tay-Sachs Disease

Hexosaminidase A Deficiency	TSD
Hexa Deficiency	Gm2 Gangliosidosis, Type 1
Hexosaminidase Alpha-Subunit Deficiency	Gm2-Gangliosidosis, Several Forms
Gm2-Gangliosidosis, B, B1, Ab Variant	B Variant Gm2 Gangliosidosis
Sphingolipidosis, Tay-Sachs	Gm2-Gangliosidosis, Type I
B Variant Gm2-Gangliosidosis	Hex A Pseudodeficiency
Hexa Disorders	Beta-Hexosaminidase A Deficiency
Gm2 Gangliosidosis, Type I	Gangliosidosis Gm2 , Type 1
Gm2 Gangliosidosis, B, B1 Variant	Gm2-Gangliosidosis 1
GM2G1	Gm2-Gangliosidosis B Variant
Tay-Sachs Disease Pseudo-Ab Variant	Tay-Sachs Disease Variant B1
Gangliosidoses, Gm2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-125798	2,3-Dehydro-2-deoxy-N-acetylneuraminic acid	Inhibitor	≥99.0%	否
HY-161943	NEU3-IN-1	Inhibitor	/	否
HY-RS09218	NEU4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	NEU4	VGNC	VGNC:75227
Bos taurus	NEU4	VGNC	VGNC:50074
Mus musculus	NEU4	MGD	MGI:2661364
Rattus norvegicus	NEU4	RGD	RGD:1308624
Felis catus	NEU4	VGNC	VGNC:63781

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NEU4 - neuraminidase 4 Gene

关于 NEU4

功能概要

NEU4 基因产物(5)

NEU4 蛋白结构

NEU4 蛋白互作信息

关联疾病

直系同源

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NEU4 - neuraminidase 4 Gene

关于 NEU4

功能概要

NEU4 基因产物(5)

NEU4 蛋白结构

NEU4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z