2,3-Dehydro-2-deoxy-N-acetylneuraminic acid (Synonyms: Neu5Ac2en; DANA)

目录号: HY-125798 纯度: ≥98.0%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂。N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid 对人 neuraminidase 酶具有抑制活性，对人 NEU1、NEU2、NEU3 和 NEU4 的 IC₅₀ 值分别为 143、43、61 和 74 μM。N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid 具有抗流感病毒活性。

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2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Chemical Structure

CAS No. : 24967-27-9

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5 mg	￥3000	In-stock
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生物活性
纯度 & 产品资料
参考文献

生物活性

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC₅₀s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	168 μM Compound: NeuAc2en	Inhibition of human NEU1 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate Inhibition of human NEU1 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate	[PMID: 18694948]
HEK293	IC₅₀	45.5 μM Compound: NeuAc2en	Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate	[PMID: 18694948]
HEK293	IC₅₀	70.3 μM Compound: NeuAc2en	Inhibition of human NEU3 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate Inhibition of human NEU3 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate	[PMID: 18694948]
HEK293	IC₅₀	73.1 μM Compound: NeuAc2en	Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate	[PMID: 18694948]
HEK-293T	IC₅₀	0.04 mM Compound: 2, Neu5Ac2en, DANA	Inhibition of human NEU2 transiently transfected in HEK293T cells by fluorimetric analysis Inhibition of human NEU2 transiently transfected in HEK293T cells by fluorimetric analysis	[PMID: 19450982]
HEK-293T	IC₅₀	0.06 mM Compound: 2, Neu5Ac2en, DANA	Inhibition of human NEU3 transiently transfected in HEK293T cells by fluorimetric high-performance liquid chromatography Inhibition of human NEU3 transiently transfected in HEK293T cells by fluorimetric high-performance liquid chromatography	[PMID: 19450982]
HEK-293T	IC₅₀	0.07 mM Compound: 2, Neu5Ac2en, DANA	Inhibition of human NEU4 transiently transfected in HEK293T cells by fluorimetric analysis Inhibition of human NEU4 transiently transfected in HEK293T cells by fluorimetric analysis	[PMID: 19450982]
HEK-293T	IC₅₀	0.143 mM Compound: 2, Neu5Ac2en, DANA	Inhibition of human NEU1 transiently transfected in HEK293T cells by fluorimetric analysis Inhibition of human NEU1 transiently transfected in HEK293T cells by fluorimetric analysis	[PMID: 19450982]
HEK-293T	IC₅₀	49 μM Compound: 1; DANA	Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay	[PMID: 29425031]
HEK-293T	IC₅₀	50 μM Compound: 2; DANA	Inhibition of human Neu3 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis Inhibition of human Neu3 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis	[PMID: 27095056]
HEK-293T	IC₅₀	50 μM Compound: 2; DANA	Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis	[PMID: 27095056]
HEK-293T	IC₅₀	50 μM Compound: 2; DANA	Inhibition of human Neu1 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis Inhibition of human Neu1 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis	[PMID: 27095056]
HEK-293T	IC₅₀	50 μM Compound: 2; DANA	Inhibition of human Neu4 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis Inhibition of human Neu4 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis	[PMID: 27095056]
HEK-293T	IC₅₀	50 μM Compound: 2; DANA	Inhibition of human Neu4 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis Inhibition of human Neu4 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis	[PMID: 27095056]

体外研究
(In Vitro)

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) 显著抑制 INS-1D 细胞中的唾液酸酶活性^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) 显著抑制 INS-1D 细胞中的唾液酸酶活性^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice (Mouse model of pulmonary fibrosis)^[3]
Dosage:	10 mg/kg
Administration:	I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21)
Result:	Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis.

Clinical Trial

分子量

291.25

Formula

C₁₁H₁₇NO₈

CAS 号

24967-27-9

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

H₂O 中的溶解度 : 33.33 mg/mL (114.44 mM; 超声助溶)

DMSO 中的溶解度 : 1 mg/mL (3.43 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4335 mL	17.1674 mL	34.3348 mL
5 mM	0.6867 mL	3.4335 mL	6.8670 mL
10 mM	0.3433 mL	1.7167 mL	3.4335 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: ≥99.0%

选择批次：

Data Sheet (607 KB) SDS (252 KB)

COA (289 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Magesh S, et al. Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). Bioorg Med Chem Lett. 2008;18(2):532-537. [Content Brief]

[2]. Xiao A, et al. Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors. ACS Catal. 2018;8(1):43-47. [Content Brief]

[3]. Karhadkar TR, et al. Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model. Sci Rep. 2017;7(1):15069. Published 2017 Nov 8. [Content Brief]

[4]. Minami A, et al. The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion. Sci Rep. 2020;10(1):5198. Published 2020 Mar 23. [Content Brief]

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.4335 mL	17.1674 mL	34.3348 mL	85.8369 mL
H₂O	5 mM	0.6867 mL	3.4335 mL	6.8670 mL	17.1674 mL
	10 mM	0.3433 mL	1.7167 mL	3.4335 mL	8.5837 mL
	15 mM	0.2289 mL	1.1445 mL	2.2890 mL	5.7225 mL
	20 mM	0.1717 mL	0.8584 mL	1.7167 mL	4.2918 mL
	25 mM	0.1373 mL	0.6867 mL	1.3734 mL	3.4335 mL
	30 mM	0.1144 mL	0.5722 mL	1.1445 mL	2.8612 mL
	40 mM	0.0858 mL	0.4292 mL	0.8584 mL	2.1459 mL
	50 mM	0.0687 mL	0.3433 mL	0.6867 mL	1.7167 mL
	60 mM	0.0572 mL	0.2861 mL	0.5722 mL	1.4306 mL
	80 mM	0.0429 mL	0.2146 mL	0.4292 mL	1.0730 mL
	100 mM	0.0343 mL	0.1717 mL	0.3433 mL	0.8584 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid24967-27-9Neu5Ac2en DANAInfluenza VirusneuraminidaseenzymespulmonaryfibrosisinsulinsecretionInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid (Synonyms: Neu5Ac2en; DANA)

Customer Review

MCE 顾客使用本产品发表的 2 篇科研文献