1. Gene
  2. UNC93B1 - unc-93 homolog B1, TLR signaling regulator Gene

UNC93B1 - unc-93 homolog B1, TLR signaling regulator Gene

中文名称:unc-93 同系物 B1,TLR 信号调节器

种属: Homo sapiens

同用名: IIAE1; UNC93; UNC93B; Unc-93B1

基因 ID: 81622 | 基因类型: protein coding

关于 UNC93B1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,991,100-68,004,097 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in spleen (RPKM 27.3), lung (RPKM 14.0) and 24 other tissues.

功能概要

该基因编码一种蛋白质,该蛋白质通过调节 Toll 样受体信号转导参与先天性和适应性免疫反应。编码的蛋白质将核苷酸感应 toll 样受体从内质网运输到内溶酶体。编码蛋白的缺乏与单纯疱疹病毒性脑炎有关。[RefSeq 提供,2014 年 2 月]

This gene encodes a protein that is involved in innate and adaptive immune response by regulating Toll-like Receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

UNC93B1 基因产物(1)

mRNA Protein Name
NM_030930.4 NP_112192.2 protein unc-93 homolog B1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Toll-like receptor binding IPI
IPI: 通过物理相互作用推断
33432245 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22164301 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in toll-like receptor 3 signaling pathway IMP
IMP: 通过突变表型推断
18082565 GOA
involved in toll-like receptor 7 signaling pathway IMP
IMP: 通过突变表型推断
19006693 GOA
involved in toll-like receptor 9 signaling pathway IMP
IMP: 通过突变表型推断
19006693 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
18082565 GOA
located in endosome IDA
IDA: 通过直接分析推断
21642595 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UNC93B1 蛋白结构

UNC-93

UNC-93: Ion channel regulatory protein UNC-93 (122 - 188)

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  • 596 a.a.
蛋白主名 其他名称

protein unc-93 homolog B1

unc-93 related protein

UNC93B1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UNC93B1 Q9H1C4 LDLRAD1 Homo sapiens Q5T700 32296183
种属内
UNC93B1 Q9H1C4 LDLRAD1 Homo sapiens Q5T700 32296183
种属内
UNC93B1 Q9H1C4 TMEM237 Homo sapiens Q96Q45-2 32296183
种属内
UNC93B1 Q9H1C4 TMEM237 Homo sapiens Q96Q45-2 32296183
种属内
UNC93B1 Q9H1C4 MFF Homo sapiens Q9GZY8-5 32296183
种属内
UNC93B1 Q9H1C4 MFF Homo sapiens Q9GZY8-5 32296183
种属内
UNC93B1 Q9H1C4 GPRC5D Homo sapiens Q9NZD1 32296183
种属内
UNC93B1 Q9H1C4 GPRC5D Homo sapiens Q9NZD1 32296183
种属内
UNC93B1 Q9H1C4 GPRC5D Homo sapiens Q9NZD1 32296183
种属内
UNC93B1 Q9H1C4 TM4SF18 Homo sapiens Q96CE8 32296183
种属内
UNC93B1 Q9H1C4 TM4SF18 Homo sapiens Q96CE8 32296183
种属内
UNC93B1 Q9H1C4 REEP1 Homo sapiens Q9H902 32296183
种属内
UNC93B1 Q9H1C4 REEP1 Homo sapiens Q9H902 32296183
种属内
UNC93B1 Q9H1C4 REEP1 Homo sapiens Q9H902 32296183
种属内
UNC93B1 Q9H1C4 SSMEM1 Homo sapiens Q8WWF3 32296183
种属内
UNC93B1 Q9H1C4 SSMEM1 Homo sapiens Q8WWF3 32296183
种属内
UNC93B1 Q9H1C4 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
种属内
UNC93B1 Q9H1C4 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
种属内
UNC93B1 Q9H1C4 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
种属内
UNC93B1 Q9H1C4 LEUTX Homo sapiens A8MZ59 32296183
种属内
UNC93B1 Q9H1C4 LEUTX Homo sapiens A8MZ59 32296183
种属内
UNC93B1 Q9H1C4 FFAR3 Homo sapiens O14843 32296183
种属内
UNC93B1 Q9H1C4 FFAR3 Homo sapiens O14843 32296183
种属内
UNC93B1 Q9H1C4 GPR101 Homo sapiens Q96P66 32296183
种属内
UNC93B1 Q9H1C4 GPR101 Homo sapiens Q96P66 32296183
种属内
UNC93B1 Q9H1C4 BEST2 Homo sapiens Q8NFU1 32296183
种属内
UNC93B1 Q9H1C4 BEST2 Homo sapiens Q8NFU1 32296183
种属间
UNC93B1 Q9H1C4 ns7b_sars2 SARS-CoV-2 P0DTD8 33845483
种属内
UNC93B1 Q9H1C4 LIME1 Homo sapiens Q9H400 32296183
种属内
UNC93B1 Q9H1C4 LIME1 Homo sapiens Q9H400 32296183
种属内
UNC93B1 Q9H1C4 LIME1 Homo sapiens Q9H400 32296183
种属内
UNC93B1 Q9H1C4 CSE1L Homo sapiens P55060 30833792
种属内
UNC93B1 Q9H1C4 KPNB1 Homo sapiens Q14974 30833792
种属内
UNC93B1 Q9H1C4 HHLA2 Homo sapiens Q9UM44 32296183
种属内
UNC93B1 Q9H1C4 HHLA2 Homo sapiens Q9UM44 32296183
种属内
UNC93B1 Q9H1C4 HHLA2 Homo sapiens Q9UM44 32296183
种属内
UNC93B1 Q9H1C4 GPR37L1 Homo sapiens O60883 32296183
种属内
UNC93B1 Q9H1C4 GPR37L1 Homo sapiens O60883 32296183
种属内
UNC93B1 Q9H1C4 EBP Homo sapiens Q15125 32296183
种属内
UNC93B1 Q9H1C4 EBP Homo sapiens Q15125 32296183
种属内
UNC93B1 Q9H1C4 CREB3L1 Homo sapiens Q96BA8 32296183
种属内
UNC93B1 Q9H1C4 CREB3L1 Homo sapiens Q96BA8 32296183
种属内
UNC93B1 Q9H1C4 SYNDIG1 Homo sapiens Q9H7V2 32296183
种属内
UNC93B1 Q9H1C4 SYNDIG1 Homo sapiens Q9H7V2 32296183
种属内
UNC93B1 Q9H1C4 SYNDIG1 Homo sapiens Q9H7V2 32296183
种属内
UNC93B1 Q9H1C4 CLDN7 Homo sapiens O95471 32296183
种属内
UNC93B1 Q9H1C4 CLDN7 Homo sapiens O95471 32296183
种属内
UNC93B1 Q9H1C4 FATE1 Homo sapiens Q969F0 32296183
种属内
UNC93B1 Q9H1C4 FATE1 Homo sapiens Q969F0 32296183
种属内
UNC93B1 Q9H1C4 CD79A Homo sapiens P11912 32296183
种属内
UNC93B1 Q9H1C4 CD79A Homo sapiens P11912 32296183
种属内
UNC93B1 Q9H1C4 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
UNC93B1 Q9H1C4 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
UNC93B1 Q9H1C4 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
UNC93B1 Q9H1C4 KLRC1 Homo sapiens P26715 32296183
种属内
UNC93B1 Q9H1C4 KLRC1 Homo sapiens P26715 32296183
种属内
UNC93B1 Q9H1C4 CCDC107 Homo sapiens Q8WV48 32296183
种属内
UNC93B1 Q9H1C4 CCDC107 Homo sapiens Q8WV48 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Encephalopathy, Acute, Infection-Induced 1

Herpes Simplex Encephalitis, Susceptibility To, 1

IIAE1

Encephalopathy, Acute, Infection-Induced , Susceptibility To, 1

Herpes Simplex Encephalitis 1

Encephalopathy, Acute, Infection-Induced, 1, Herpes-Specific

Encephalopathy, Acute, Infection-Induced, 1

Hse1

Infection-Induced Acute Encephalopathy 1

Herpes Simplex Encephalitis

Hse

Hsv Encephalitis

Hsve

Herpes Simplex Meningo-Encephalitis

Herpes Simplex Neuroinvasion

Herpes Simplex Virus Encephalitis

Herpetic Encephalitis

Herpes Encephalitis

Herpes Simplex Virus 1 Encephalitis

Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis

Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Melkersson-Rosenthal Syndrome

Melkersson Syndrome

Mros

Mrs

Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal

Melkersson'S Syndrome

Cheilitis Granulomatosa

Granulomatous Cheilitis

Immunodeficiency 31b

IMD31B

Immunodeficiency 31b, Mycobacterial And Viral Infections, Autosomal Recessive

Autosomal Recessive Stat1 Deficiency

Predisposition To Severe Viral Infection Due To Stat1 Deficiency

Susceptibility To Viral And Mycobacterial Infections Due To Stat1 Deficiency

Stat1 Deficiency, Autosomal Recessive

Autosomal Recessive Immunodeficiency 31b, Mycobacterial And Viral Infections

Stat1 Deficiency

Autosomal Recessive Susceptibility To Mycobacterial And Viral Infections

Mycobacterial And Viral Infections Due To Complete Stat1 Deficiency

Immunodeficiency, Type 31b, Mycobacterial And Viral Infections, Autosomal Recessive

Viral Encephalitis

Epidemic Encephalitis

Encephalitis Viral

Encephalitis, Arbovirus

Arbovirus Encephalitis

Postviral Encephalitis Nos

Equine Encephalitis

Tick-Borne Encephalitis

Viral Encephalitis Transmitted By Tick

Mosquito-Borne Encephalitis

Acute Haemorrhagic Encephalitis

Acute Idiopathic Encephalitis

Chronic Viral Encephalitis

Endemic Encephalitis

Subacute Viral Encephalitis

Viral Haemorrhagic Encephalitis

Viral Nonepidemic Encephalitis

Nonepidemic Encephalitis

Acute Necrotizing Encephalitis

Acute Necrotizing Encephalopathy

Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy

Ane

Acute Necrotizing Encephalopathy Type 1

Adane

Ane1

Autosomal Dominant Acute Necrotizing Encephalopathy

Iiae3

Susceptibility To Acute Necrotizing Encephalopathy

Susceptibility To Infection-Induced Acute Encephalopathy

Encephalopathy, Acute Necrotizing, Susceptibility To

Encephalitis, Acute Necrotizing

Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2

FHL2

Hplh2

Hlh2

Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To

Lymphohistiocytosis, Hemophagocytic, Familial, Type 2

X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked

Imd74

Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

Tlr7 Deficiency

X-Linked Immunodeficiency 74,Covid-19-Related

Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus UNC93B1 MGD MGI:1859307
Canis familiaris UNC93B1 VGNC VGNC:49636
Macaca mulatta UNC93B1 VGNC VGNC:78927
Bos taurus UNC93B1 VGNC VGNC:49587
Felis catus UNC93B1 VGNC VGNC:66836
Rattus norvegicus UNC93B1 RGD RGD:1311984