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  2. FFAR3 - free fatty acid receptor 3 Gene

FFAR3 - free fatty acid receptor 3 Gene

中文名称:游离脂肪酸受体 3

种属: Homo sapiens

同用名: FFA3R; GPR41; GPR42

基因 ID: 2865 | 基因类型: protein coding

关于 FFAR3

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,358,151-35,360,489 (from NCBI)

This gene has 2 transcripts (splice variants), 339 orthologues and 15 paralogues. Biased expression in appendix (RPKM 1.2), fat (RPKM 0.6) and 13 other tissues.

功能概要

启用 G 蛋白偶联受体活性。参与腺苷酸环化酶抑制 G 蛋白偶联受体信号通路和细胞对脂肪酸的反应。位于质膜。 [由基因组资源联盟提供,2022 年 4 月]

Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

FFAR3 基因产物(1)

mRNA Protein Name
NM_005304.5 NP_005295.1 free fatty acid receptor 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
12496283 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
12496283 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
14722361 GOA
involved in cellular response to fatty acid IDA
IDA: 通过直接分析推断
12496283 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
18801738 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FFAR3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (32 - 276)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
蛋白主名 其他名称

free fatty acid receptor 3

G-protein coupled receptor 41

FFAR3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra FFAR3 O14843 TEX264 Homo sapiens Q9Y6I9
Validated Y2H
32296183
Intra FFAR3 O14843 TOMM6 Homo sapiens Q96B49
Validated Y2H
32296183
Intra FFAR3 O14843 CTXN3 Homo sapiens Q4LDR2
Validated Y2H
32296183
Intra FFAR3 O14843 LTC4S Homo sapiens Q16873
Validated Y2H
32296183
Intra FFAR3 O14843 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra FFAR3 O14843 TREX1 Homo sapiens Q9NSU2-1
Validated Y2H
32296183
Intra FFAR3 O14843 EFNA5 Homo sapiens P52803
Validated Y2H
32296183
Intra FFAR3 O14843 SERINC1 Homo sapiens Q9NRX5
Validated Y2H
32296183
Intra FFAR3 O14843 COMT Homo sapiens P21964
Validated Y2H
32296183
Intra FFAR3 O14843 UNC93B1 Homo sapiens Q9H1C4
Validated Y2H
32296183
Intra FFAR3 O14843 KCNIP3 Homo sapiens Q9Y2W7
Y2H Array
32814053
Intra FFAR3 O14843 KCNIP3 Homo sapiens Q9Y2W7
Validated Y2H
32814053
Intra FFAR3 O14843 KCNIP3 Homo sapiens Q9Y2W7
Y2H Pooling
32814053
Intra FFAR3 O14843 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra FFAR3 O14843 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra FFAR3 O14843 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra FFAR3 O14843 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
Intra FFAR3 O14843 LAT Homo sapiens O43561-2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diversion Colitis
Anaerobic Meningitis
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus FFAR3 MGD MGI:2685324
Rattus norvegicus FFAR3 RGD RGD:1311035