2. Gene
  3. GPR37L1 - G protein-coupled receptor 37 like 1 Gene

GPR37L1 - G protein-coupled receptor 37 like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 37 样 1

种属: Homo sapiens

同用名: ETBRLP2; ETBR-LP-2; ET(B)R-LP-2

基因 ID: 9283 | 基因类型: protein coding

关于 GPR37L1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,122,917-202,133,592 (from NCBI)

This gene has 7 transcripts (splice variants), 264 orthologues and 15 paralogues. Biased expression in brain (RPKM 18.1) and colon (RPKM 0.5).

功能概要

启用 G 蛋白偶联肽受体活性；肽结合活性；和 prosaposin 受体活性。参与腺苷酸环化酶抑制 G 蛋白偶联受体信号通路和 MAPK 级联的正调控。位于质膜。受体复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GPR37L1 基因产物(1)

mRNA Protein Name
NM_004767.5 NP_004758.3 G-protein coupled receptor 37-like 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled peptide receptor activity IDA
IDA: 通过直接分析推断
23690594 GOA
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
27072655 GOA
enables peptide binding IPI
IPI: 通过物理相互作用推断
23690594 GOA
NOT enables prosaposin receptor activity IDA
IDA: 通过直接分析推断
27072655 GOA
enables prosaposin receptor activity IDA
IDA: 通过直接分析推断
23690594 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20517885 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
23690594 GOA
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
23690594 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
28688853 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR37L1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (147 - 396)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
蛋白主名 其他名称

G-protein coupled receptor 37-like 1

endothelin B receptor-like protein 2

GPR37L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GPR37L1 O60883 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
种属内
GPR37L1 O60883 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
种属内
GPR37L1 O60883 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
种属内
GPR37L1 O60883 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
种属内
GPR37L1 O60883 SYNPR Homo sapiens Q8TBG9
Validated Y2H
32296183
种属内
GPR37L1 O60883 SYNPR Homo sapiens Q8TBG9
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 SYNPR Homo sapiens Q8TBG9
Y2H Array
32296183
种属内
GPR37L1 O60883 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
种属内
GPR37L1 O60883 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
种属内
GPR37L1 O60883 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
种属内
GPR37L1 O60883 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
种属内
GPR37L1 O60883 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
种属内
GPR37L1 O60883 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
种属内
GPR37L1 O60883 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
种属内
GPR37L1 O60883 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
种属内
GPR37L1 O60883 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
种属内
GPR37L1 O60883 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
种属内
GPR37L1 O60883 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
种属内
GPR37L1 O60883 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
种属内
GPR37L1 O60883 CLDND2 Homo sapiens Q8NHS1
Validated Y2H
32296183
种属内
GPR37L1 O60883 TMEM86A Homo sapiens Q8N2M4
Validated Y2H
32296183
种属内
GPR37L1 O60883 SCARF1 Homo sapiens Q14162
Validated Y2H
32296183
种属内
GPR37L1 O60883 TMEM97 Homo sapiens Q5BJF2
Validated Y2H
32296183
种属内
GPR37L1 O60883 STOM Homo sapiens P27105
Validated Y2H
32296183
种属内
GPR37L1 O60883 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 STOM Homo sapiens P27105
Y2H Array
32296183
种属内
GPR37L1 O60883 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
种属内
GPR37L1 O60883 UPK1B Homo sapiens O75841
Validated Y2H
32296183
种属内
GPR37L1 O60883 AQP10 Homo sapiens Q96PS8
Validated Y2H
32296183
种属内
GPR37L1 O60883 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
种属内
GPR37L1 O60883 CD46 Homo sapiens P15529-3
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 CD46 Homo sapiens P15529-3
Validated Y2H
32296183
种属内
GPR37L1 O60883 CD46 Homo sapiens P15529-3
Y2H Array
32296183
种属内
GPR37L1 O60883 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
种属内
GPR37L1 O60883 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
GPR37L1 O60883 SCARB2 Homo sapiens Q14108
Validated Y2H
32296183
种属内
GPR37L1 O60883 CLEC2A Homo sapiens Q6UVW9
Validated Y2H
32296183
种属内
GPR37L1 O60883 CLEC2A Homo sapiens Q6UVW9
Y2H Array
32296183
种属内
GPR37L1 O60883 CLEC2A Homo sapiens Q6UVW9
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
种属内
GPR37L1 O60883 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
种属内
GPR37L1 O60883 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 GPR42 Homo sapiens O15529
Y2H Array
32296183
种属内
GPR37L1 O60883 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
种属内
GPR37L1 O60883 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
种属内
GPR37L1 O60883 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
种属内
GPR37L1 O60883 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
GPR37L1 O60883 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
种属内
GPR37L1 O60883 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
种属内
GPR37L1 O60883 RNF122 Homo sapiens Q9H9V4
Validated Y2H
32296183
种属内
GPR37L1 O60883 RNF122 Homo sapiens Q9H9V4
Y2H Array
32296183
种属内
GPR37L1 O60883 RNF122 Homo sapiens Q9H9V4
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 TSPAN12 Homo sapiens O95859
Validated Y2H
32296183
种属内
GPR37L1 O60883 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
种属内
GPR37L1 O60883 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
种属内
GPR37L1 O60883 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
种属内
GPR37L1 O60883 PRCP Homo sapiens P42785
Protease Assay
20517885
种属内
GPR37L1 O60883 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
种属内
GPR37L1 O60883 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
种属内
GPR37L1 O60883 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 FFAR2 Homo sapiens O15552
Y2H Array
32296183
种属内
GPR37L1 O60883 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
种属内
GPR37L1 O60883 TMEM54 Homo sapiens Q969K7
Validated Y2H
32296183
种属内
GPR37L1 O60883 UNC93B1 Homo sapiens Q9H1C4
Validated Y2H
32296183
种属内
GPR37L1 O60883 PLN Homo sapiens P26678
Validated Y2H
32296183
种属内
GPR37L1 O60883 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
GPR37L1 O60883 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
种属内
GPR37L1 O60883 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
种属内
GPR37L1 O60883 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
种属内
GPR37L1 O60883 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 THAP4 Homo sapiens Q8WY91
Validated Y2H
32296183
种属内
GPR37L1 O60883 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
种属内
GPR37L1 O60883 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
种属内
GPR37L1 O60883 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
种属内
GPR37L1 O60883 CLDN7 Homo sapiens O95471
Y2H Array
32296183
种属内
GPR37L1 O60883 AQP1 Homo sapiens P29972
Validated Y2H
32296183
种属内
GPR37L1 O60883 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
种属内
GPR37L1 O60883 TM4SF4 Homo sapiens P48230
Validated Y2H
32296183
种属内
GPR37L1 O60883 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Epilepsy, Familial Temporal Lobe, 6

ETL6

Familial Temporal Lobe Epilepsy 6
Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts

Mlc

Van Der Knaap Disease

Lvm

Leukoencephalopathy With Swelling And Cysts

Megalencephaly-Cystic Leukodystrophy

Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome

Infantile Leukoencephalopathy And Megalencephaly

Leukoencephalopathy With Swelling And A Discrepantly Mild Course

Vacuolating Leukoencephalopathy

Megalencephalic Leukodystrophy

Megalencephaly-Cystic Leukodystrophy Syndrome

Van Der Knaap Syndrome

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1342A Prosaptide Tx14(A) TFA Activator / 否
HY-RS05710 GPR37L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GPR37L1 VGNC VGNC:62691
Canis familiaris GPR37L1 VGNC VGNC:41433
Macaca mulatta GPR37L1 VGNC VGNC:72943
Mus musculus GPR37L1 MGD MGI:1928503
Bos taurus GPR37L1 VGNC VGNC:29586
Rattus norvegicus GPR37L1 RGD RGD:628835
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