2. Gene
  3. INSIG2 - insulin induced gene 2 Gene

INSIG2 - insulin induced gene 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胰岛素诱导基因 2

种属: Homo sapiens

同用名: INSIG-2

基因 ID: 51141 | 基因类型: protein coding

关于 INSIG2

Cytogenetic location: 2q14.1-q14.2 Genomic coordinates (GRCh38): 2:118,088,471-118,110,997 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 12.3), lung (RPKM 10.5) and 25 other tissues.

功能概要

该基因编码的蛋白质与 INSIG1 基因编码的蛋白质产物高度相似。 INSIG1 蛋白和该蛋白都是内质网蛋白，通过与 SREBP 裂解激活蛋白 (SCAP) 结合来阻断甾醇调节元件结合蛋白 (SREBP) 的加工，从而阻止 SCAP 护送 SREBP 到高尔基体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

INSIG2 基因产物(6)

mRNA Protein Name
NM_001321329.2 NP_001308258.1 insulin-induced gene 2 protein isoform a
NM_001321330.2 NP_001308259.1 insulin-induced gene 2 protein isoform b
NM_001321331.2 NP_001308260.1 insulin-induced gene 2 protein isoform b
NM_001321332.2 NP_001308261.1 insulin-induced gene 2 protein isoform b
NM_001321333.2 NP_001308262.1 insulin-induced gene 2 protein isoform c
NM_016133.4 NP_057217.2 insulin-induced gene 2 protein isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables oxysterol binding IDA
IDA: 通过直接分析推断
17428920 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12242332 GOA
enables protein sequestering activity IDA
IDA: 通过直接分析推断
15899885 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SREBP signaling pathway IDA
IDA: 通过直接分析推断
12242332 GOA
involved in SREBP-SCAP complex retention in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15899885 GOA
involved in cholesterol biosynthetic process IDA
IDA: 通过直接分析推断
32322062 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SREBP-SCAP-Insig complex IDA
IDA: 通过直接分析推断
12242332 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
32322062 GOA
is active in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
32322062 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INSIG2 蛋白结构

INSIG

INSIG: Insulin-induced protein (INSIG) (29 - 211)

  • 0
  • 100
  • 200
  • 225 a.a.
蛋白主名 其他名称

insulin-induced gene 2 protein

INSIG2 membrane protein

INSIG2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
INSIG2 Q9Y5U4 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 AQP2 Homo sapiens P41181
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 GJA8 Homo sapiens P48165
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 SLC16A10 Homo sapiens Q8TF71
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 SLC16A10 Homo sapiens Q8TF71
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 LAPTM5 Homo sapiens Q13571
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 LAPTM5 Homo sapiens Q13571
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Validated Y2H
25416956
种属内
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
25416956
种属内
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 ATP6V0B Homo sapiens Q99437
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 ATP6V0B Homo sapiens Q99437
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 EBP Homo sapiens Q15125
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 PVR Homo sapiens P15151
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 STIM1 Homo sapiens Q13586
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 STIM1 Homo sapiens Q13586
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 PRLR Homo sapiens P16471
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 PRLR Homo sapiens P16471
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 CD40 Homo sapiens P25942
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 BIK Homo sapiens Q13323
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 ABHD4 Homo sapiens Q8TB40
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 ABHD4 Homo sapiens Q8TB40
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 CD79A Homo sapiens P11912
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
种属内
INSIG2 Q9Y5U4 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属内
INSIG2 Q9Y5U4 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Leptin

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction
Diabetes Mellitus

Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06838 INSIG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta INSIG2 VGNC VGNC:73632
Bos taurus INSIG2 VGNC VGNC:30218
Rattus norvegicus INSIG2 RGD RGD:631417
Canis familiaris INSIG2 VGNC VGNC:42040
Mus musculus INSIG2 MGD MGI:1920249
Felis catus INSIG2 VGNC VGNC:62933
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