2. Gene
  3. LAPTM5 - lysosomal protein transmembrane 5 Gene

LAPTM5 - lysosomal protein transmembrane 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶酶体蛋白跨膜 5

种属: Homo sapiens

同用名: CLAST6

基因 ID: 7805 | 基因类型: protein coding

关于 LAPTM5

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:30,732,469-30,757,774 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 488.0), lymph node (RPKM 349.3) and 15 other tissues.

功能概要

该基因编码与溶酶体相关的跨膜受体。编码的蛋白质，也称为 E3 蛋白，可能在造血过程中发挥作用。[RefSeq 提供，2009 年 2 月]

This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

LAPTM5 基因产物(1)

mRNA Protein Name
NM_006762.3 NP_006753.1 lysosomal-associated transmembrane protein 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17116753 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
17116753 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
28464033 GOA
involved in defense response to tumor cell IDA
IDA: 通过直接分析推断
19787053 GOA
involved in induction of programmed cell death IDA
IDA: 通过直接分析推断
19787053 GOA
involved in negative regulation of autophagic cell death IDA
IDA: 通过直接分析推断
19787053 GOA
involved in positive regulation of lysosomal membrane permeability IDA
IDA: 通过直接分析推断
19787053 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
22009753 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
17116753 GOA
located in lysosome IDA
IDA: 通过直接分析推断
8661146 GOA
located in perinuclear region of cytoplasm IMP
IMP: 通过突变表型推断
28464033 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
8661146 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
17116753 GOA
located in transport vesicle IDA
IDA: 通过直接分析推断
19787053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LAPTM5 蛋白结构

Mtp

Mtp: Golgi 4-transmembrane spanning transporter (28 - 261)

  • 0
  • 100
  • 200
  • 262 a.a.
蛋白主名 其他名称

lysosomal-associated transmembrane protein 5

CD40-ligand-activated specific transcripts

LAPTM5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LAPTM5 Q13571 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
25416956
Intra LAPTM5 Q13571 DISP1 Homo sapiens Q96F81
Y2H Prey Pooling
25416956
Intra LAPTM5 Q13571 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra LAPTM5 Q13571 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra LAPTM5 Q13571 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra LAPTM5 Q13571 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra LAPTM5 Q13571 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra LAPTM5 Q13571 KIR3DL3 Homo sapiens Q8N743
Validated Y2H
32296183
Intra LAPTM5 Q13571 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra LAPTM5 Q13571 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra LAPTM5 Q13571 MRPL18 Homo sapiens Q9H0U6
Validated Y2H
32296183
Intra LAPTM5 Q13571 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra LAPTM5 Q13571 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pigmented Villonodular Synovitis

Diffuse Giant Cell Tumor Of Tenosynovium

Villous Tenosynovitis

Diffuse Pigmented Villonodular Synovitis

Diffuse-Type Gct

Diffuse-Type Giant Cell Tumor

Localized Pigmented Villonodular Synovitis

Tgct

Tsgct

Tenosynovial Giant Cell Tumor

Tenosynovial Giant Cell Tumors

Synovitis Pigmented Villonodular

Synovitis, Pigmented Villonodular

Fibrous Histiocytoma Of Tendon Sheath

Testicular Germ Cell Tumor

Chronic Haemorrhagic Villous Synovitis

Pvns - [Pigmented Villonodular Synovitis]

Villonodular Synovitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07523 LAPTM5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LAPTM5 RGD RGD:621838
Bos taurus LAPTM5 VGNC VGNC:30788
Canis familiaris LAPTM5 VGNC VGNC:42584
Macaca mulatta LAPTM5 VGNC VGNC:74162
Felis catus LAPTM5 VGNC VGNC:63190
Mus musculus LAPTM5 MGD MGI:108046
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