1. Gene
  2. UBE2J1 - ubiquitin conjugating enzyme E2 J1 Gene

UBE2J1 - ubiquitin conjugating enzyme E2 J1 Gene

中文名称:泛素结合酶 E2 J1

种属: Homo sapiens

同用名: UBC6; UBC6E; Ubc6p; CGI-76; NCUBE1; HSPC153; HSPC205; NCUBE-1; HSU93243

基因 ID: 51465 | 基因类型: protein coding

关于 UBE2J1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,326,625-89,352,722 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues and 24 paralogues. Ubiquitous expression in lymph node (RPKM 49.6), bone marrow (RPKM 46.1) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶:泛素激活酶或 E1、泛素结合酶或 E2,以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。这种酶位于内质网 (ER) 的膜中,可能有助于泛素-蛋白酶体系统对 ER 相关降解的质量控制。[RefSeq 提供,2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

UBE2J1 基因产物(1)

mRNA Protein Name
NM_016021.3 NP_057105.2 ubiquitin-conjugating enzyme E2 J1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IDA
IDA: 通过直接分析推断
33472082 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19690564 GOA
enables ubiquitin conjugating enzyme activity IMP
IMP: 通过突变表型推断
21245296 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
11439185 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ERAD pathway IMP
IMP: 通过突变表型推断
21245296 GOA
involved in ERAD pathway IMP
IMP: 通过突变表型推断
22607976 GOA
involved in negative regulation of retrograde protein transport, ER to cytosol IMP
IMP: 通过突变表型推断
25660456 GOA
involved in protein N-linked glycosylation via asparagine IMP
IMP: 通过突变表型推断
22607976 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
33472082 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBE2J1 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (14 - 121)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 J1

E2 ubiquitin-conjugating enzyme J1

UBE2J1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2J1 Q9Y385 JAGN1 Homo sapiens Q8N5M9 32296183
种属内
UBE2J1 Q9Y385 JAGN1 Homo sapiens Q8N5M9 32296183
种属内
UBE2J1 Q9Y385 LYVE1 Homo sapiens Q9Y5Y7 32296183
种属内
UBE2J1 Q9Y385 LYVE1 Homo sapiens Q9Y5Y7 32296183
种属内
UBE2J1 Q9Y385 LYVE1 Homo sapiens Q9Y5Y7 32296183
种属内
UBE2J1 Q9Y385 ZDHHC15 Homo sapiens Q96MV8 32296183
种属内
UBE2J1 Q9Y385 ZDHHC15 Homo sapiens Q96MV8 32296183
种属内
UBE2J1 Q9Y385 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
UBE2J1 Q9Y385 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
UBE2J1 Q9Y385 PROKR2 Homo sapiens Q8NFJ6 32296183
种属内
UBE2J1 Q9Y385 PROKR2 Homo sapiens Q8NFJ6 32296183
种属内
UBE2J1 Q9Y385 TLCD4 Homo sapiens Q96MV1 32296183
种属内
UBE2J1 Q9Y385 TLCD4 Homo sapiens Q96MV1 32296183
种属内
UBE2J1 Q9Y385 PLPPR2 Homo sapiens Q96GM1 32296183
种属内
UBE2J1 Q9Y385 PLPPR2 Homo sapiens Q96GM1 32296183
种属内
UBE2J1 Q9Y385 CDS1 Homo sapiens Q92903 32296183
种属内
UBE2J1 Q9Y385 CDS1 Homo sapiens Q92903 32296183
种属内
UBE2J1 Q9Y385 TM4SF18 Homo sapiens Q96CE8 32296183
种属内
UBE2J1 Q9Y385 TM4SF18 Homo sapiens Q96CE8 32296183
种属内
UBE2J1 Q9Y385 GOLT1A Homo sapiens Q6ZVE7 32296183
种属内
UBE2J1 Q9Y385 GOLT1A Homo sapiens Q6ZVE7 32296183
种属内
UBE2J1 Q9Y385 MS4A6E Homo sapiens Q96DS6 32296183
种属内
UBE2J1 Q9Y385 MS4A6E Homo sapiens Q96DS6 32296183
种属内
UBE2J1 Q9Y385 SLC26A5 Homo sapiens P58743-6 32296183
种属内
UBE2J1 Q9Y385 SLC26A5 Homo sapiens P58743-6 32296183
种属内
UBE2J1 Q9Y385 TRHR Homo sapiens P34981 32296183
种属内
UBE2J1 Q9Y385 TRHR Homo sapiens P34981 32296183
种属内
UBE2J1 Q9Y385 SLC10A6 Homo sapiens Q3KNW5 32296183
种属内
UBE2J1 Q9Y385 SLC10A6 Homo sapiens Q3KNW5 32296183
种属内
UBE2J1 Q9Y385 FAM209A Homo sapiens Q5JX71 32296183
种属内
UBE2J1 Q9Y385 FAM209A Homo sapiens Q5JX71 32296183
种属内
UBE2J1 Q9Y385 ELOVL4 Homo sapiens Q9GZR5 32296183
种属内
UBE2J1 Q9Y385 ELOVL4 Homo sapiens Q9GZR5 32296183
种属内
UBE2J1 Q9Y385 FAM210B Homo sapiens Q96KR6 32296183
种属内
UBE2J1 Q9Y385 FAM210B Homo sapiens Q96KR6 32296183
种属内
UBE2J1 Q9Y385 NME2P1 Homo sapiens O60361 33961781
种属内
UBE2J1 Q9Y385 NME2P1 Homo sapiens O60361 28514442
种属内
UBE2J1 Q9Y385 SEC11C Homo sapiens Q9BY50 32296183
种属内
UBE2J1 Q9Y385 SEC11C Homo sapiens Q9BY50 32296183
种属内
UBE2J1 Q9Y385 LAPTM5 Homo sapiens Q13571 32296183
种属内
UBE2J1 Q9Y385 LAPTM5 Homo sapiens Q13571 32296183
种属内
UBE2J1 Q9Y385 MFSD14B Homo sapiens Q5SR56 32296183
种属内
UBE2J1 Q9Y385 MFSD14B Homo sapiens Q5SR56 32296183
种属内
UBE2J1 Q9Y385 EBP Homo sapiens Q15125 32296183
种属内
UBE2J1 Q9Y385 EBP Homo sapiens Q15125 32296183
种属内
UBE2J1 Q9Y385 CLTRN Homo sapiens Q9HBJ8 32296183
种属内
UBE2J1 Q9Y385 GKN1 Homo sapiens Q9NS71 32296183
种属内
UBE2J1 Q9Y385 GKN1 Homo sapiens Q9NS71 32296183
种属内
UBE2J1 Q9Y385 DERL1 Homo sapiens Q9BUN8 32296183
种属内
UBE2J1 Q9Y385 DERL1 Homo sapiens Q9BUN8 32296183
种属内
UBE2J1 Q9Y385 TMX2 Homo sapiens Q9Y320 32296183
种属内
UBE2J1 Q9Y385 TMX2 Homo sapiens Q9Y320 32296183
种属内
UBE2J1 Q9Y385 TM4SF19 Homo sapiens Q96DZ7 32296183
种属内
UBE2J1 Q9Y385 TM4SF19 Homo sapiens Q96DZ7 32296183
种属内
UBE2J1 Q9Y385 TMEM51 Homo sapiens Q9NW97 32296183
种属内
UBE2J1 Q9Y385 TMEM51 Homo sapiens Q9NW97 32296183
种属内
UBE2J1 Q9Y385 REEP4 Homo sapiens Q9H6H4 32296183
种属内
UBE2J1 Q9Y385 REEP4 Homo sapiens Q9H6H4 32296183
种属内
UBE2J1 Q9Y385 CD79A Homo sapiens P11912 32296183
种属内
UBE2J1 Q9Y385 CD79A Homo sapiens P11912 32296183
种属内
UBE2J1 Q9Y385 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
UBE2J1 Q9Y385 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
UBE2J1 Q9Y385 TMEM14B Homo sapiens Q9NUH8 32296183
种属内
UBE2J1 Q9Y385 TMEM14B Homo sapiens Q9NUH8 32296183
种属内
UBE2J1 Q9Y385 CYB561 Homo sapiens P49447 32296183
种属内
UBE2J1 Q9Y385 CYB561 Homo sapiens P49447 32296183
种属内
UBE2J1 Q9Y385 LY6G6C Homo sapiens O95867 32296183
种属内
UBE2J1 Q9Y385 LY6G6C Homo sapiens O95867 32296183
种属内
UBE2J1 Q9Y385 SYVN1 Homo sapiens Q86TM6 19690564
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus UBE2J1 MGD MGI:1926245
Canis familiaris UBE2J1 VGNC VGNC:48055
Rattus norvegicus UBE2J1 RGD RGD:1305067
Felis catus UBE2J1 VGNC VGNC:66760
Macaca mulatta UBE2J1 VGNC VGNC:83963
Bos taurus UBE2J1 VGNC VGNC:36585
Others UBE2J1 NCBI