1. Gene
  2. TM4SF19 - transmembrane 4 L six family member 19 Gene

TM4SF19 - transmembrane 4 L six family member 19 Gene

中文名称:跨膜 4 L 6 家族成员 19

种属: Homo sapiens

同用名: OCTM4

基因 ID: 116211 | 基因类型: protein coding

关于 TM4SF19

This gene has 4 transcripts (splice variants), 179 orthologues and 5 paralogues. Biased expression in testis (RPKM 3.1), esophagus (RPKM 0.9) and 10 other tissues.

功能概要

该基因编码的蛋白质是四次跨膜 L6 超家族的成员。该家族的成员通过与整合素的相互作用在各种细胞过程中发挥作用,包括细胞增殖、运动和粘附。在人脑组织中,该基因在顶叶、枕叶、海马、脑桥、白质、胼胝体和小脑中高水平表达。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2017 年 5 月]

The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

TM4SF19 基因产物(3)

mRNA Protein Name
NM_001204897.2 NP_001191826.1 transmembrane 4 L6 family member 19 isoform 2
NM_001204898.2 NP_001191827.1 transmembrane 4 L6 family member 19 isoform 3
NM_138461.4 NP_612470.2 transmembrane 4 L6 family member 19 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of osteoclast differentiation IMP
IMP: 通过突变表型推断
38016540 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TM4SF19 蛋白结构

L6_membrane

L6_membrane: L6 membrane protein (10 - 209)

  • 0
  • 100
  • 209 a.a.
蛋白主名 其他名称

transmembrane 4 L6 family member 19

osteoclast maturation-associated gene 4 protein

TM4SF19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TM4SF19 Q96DZ7 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
种属内
TM4SF19 Q96DZ7 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
种属内
TM4SF19 Q96DZ7 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
种属内
TM4SF19 Q96DZ7 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
种属内
TM4SF19 Q96DZ7 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
种属内
TM4SF19 Q96DZ7 C4orf3 Homo sapiens Q8WVX3-2
Y2H Prey Pooling
32296183
种属内
TM4SF19 Q96DZ7 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
TM4SF19 Q96DZ7 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
TM4SF19 Q96DZ7 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
种属内
TM4SF19 Q96DZ7 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
种属内
TM4SF19 Q96DZ7 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
种属内
TM4SF19 Q96DZ7 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
种属内
TM4SF19 Q96DZ7 GET1 Homo sapiens O00258
Y2H Array
32296183
种属内
TM4SF19 Q96DZ7 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
种属内
TM4SF19 Q96DZ7 ATP6V0B Homo sapiens Q99437
Validated Y2H
32296183
种属内
TM4SF19 Q96DZ7 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
种属内
TM4SF19 Q96DZ7 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
种属内
TM4SF19 Q96DZ7 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
种属内
TM4SF19 Q96DZ7 CD79A Homo sapiens P11912
Y2H Array
32296183
种属内
TM4SF19 Q96DZ7 CCDC167 Homo sapiens Q9P0B6
Validated Y2H
32296183
种属内
TM4SF19 Q96DZ7 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency

IMD46

Cid Due To Tfrc Deficiency

Combined Immunodeficiency Due To Tfrc Deficiency

Chromosome 3q29 Deletion Syndrome

Chromosome 3q29 Microdeletion Syndrome

3q29 Microdeletion Syndrome

3q Subtelomere Deletion Syndrome

3q29 Recurrent Deletion

3qter Deletion

3q29 Deletion Syndrome

Monosomy 3q29

Microdeletion 3q29 Syndrome

Del(3)(Q29)

Monosomy 3qter

3q29 Deletion

Del3q29

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TM4SF19 RGD RGD:1560486
Mus musculus TM4SF19 MGD MGI:3645933