2. Gene
  3. TRHR - thyrotropin releasing hormone receptor Gene

TRHR - thyrotropin releasing hormone receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：促甲状腺激素释放激素受体

种属: Homo sapiens

同用名: CHNG7; TRH-R

基因 ID: 7201 | 基因类型: protein coding

关于 TRHR

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:109,086,585-109,121,565 (from NCBI)

This gene has 2 transcripts (splice variants), 269 orthologues, 15 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码促甲状腺素释放激素 (TRH) 的 G 蛋白偶联受体。与 TRH 结合后，该受体激活肌醇磷脂-钙-蛋白激酶 C 转导通路。该基因的突变与普遍的促甲状腺激素释放激素抵抗有关。[RefSeq 提供，2011 年 9 月]

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

TRHR 基因产物(1)

mRNA Protein Name
NM_003301.7 NP_003292.1 thyrotropin-releasing hormone receptor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRHR 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (42 - 320)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

thyrotropin-releasing hormone receptor

thyroliberin receptor

TRHR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRHR P34981 TMEFF2 Homo sapiens Q9UIK5
Validated Y2H
32296183
种属内
TRHR P34981 TMEM239 Homo sapiens Q8WW34-2
Validated Y2H
32296183
种属内
TRHR P34981 C1QL4 Homo sapiens Q86Z23
Validated Y2H
32296183
种属内
TRHR P34981 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
种属内
TRHR P34981 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
种属内
TRHR P34981 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
种属内
TRHR P34981 EFNA5 Homo sapiens P52803
Validated Y2H
32296183
种属内
TRHR P34981 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
种属内
TRHR P34981 ACP2 Homo sapiens P11117
Anti Tag CoIP
28514442
种属内
TRHR P34981 ACP2 Homo sapiens P11117
Anti Tag CoIP
33961781
种属内
TRHR P34981 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
种属内
TRHR P34981 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
种属内
TRHR P34981 NIPAL4 Homo sapiens Q0D2K0
Validated Y2H
32296183
种属内
TRHR P34981 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypothyroidism, Congenital, Nongoitrous, 7

CHNG7

Thyrotropin-Releasing Hormone Resistance, Generalized

Central Hypothyroidism Due To Trh Receptor Deficiency

Resistance To Thyrotropin-Releasing Hormone Syndrome

Trh Resistance Syndrome

Congenital Nongoitrous Hypothyroidism 7

Hypothyroidism, Congenital, Non-Goitrous, 7

Hypothyroidism, Congenital, Nongoitrous, Type 7
Hypothyroidism

Thyroid Diseases

Thyroid Disease

Thyroid Deficiency

Thyroid Insufficiency

Dysfunction Thyroid

Thyroid Dysfunction
Hypothyroidism, Central, With Testicular Enlargement

X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement

CHTE

Hypothyroidism, Central, And Testicular Enlargement

Igsf1 Deficiency Syndrome

X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism

Central Hypothyroidism And Testicular Enlargement

Hypothyroidism, Central, Testicular Enlargement
Acromegaly

Gigantism

Growth Hormone Excess

Pituitary Giant

Somatotroph Adenoma

Growth Hormone-Secreting Pituitary Adenoma
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Hyperthyroidism

Overactive Thyroid
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0596 Taltirelin 99.86% 否
HY-B0596A Taltirelin acetate 98.77% 否
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-B0596S Taltirelin-13C,d3 / 否
HY-RS15013 TRHR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRHR VGNC VGNC:36306
Mus musculus TRHR MGD MGI:98824
Felis catus TRHR VGNC VGNC:66526
Rattus norvegicus TRHR RGD RGD:3904
Macaca mulatta TRHR VGNC VGNC:78645
Canis familiaris TRHR VGNC VGNC:47799
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