1. Gene
  2. SLC39A2 - solute carrier family 39 member 2 Gene

SLC39A2 - solute carrier family 39 member 2 Gene

中文名称:溶质载体家族 39 成员 2

种属: Homo sapiens

同用名: 6A1; ZIP2; ETI-1; ZIP-2

基因 ID: 29986 | 基因类型: protein coding

关于 SLC39A2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,999,293-21,001,871 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 2 paralogues. Biased expression in skin (RPKM 12.0), esophagus (RPKM 8.3) and 3 other tissues.

功能概要

该基因编码金属离子转运蛋白 ZIP 家族的一个成员。编码的蛋白质起锌转运蛋白的作用。该基因的突变可能与颈动脉疾病的易感性有关。已经描述了多个转录变体。[RefSeq 提供,2010 年 3 月]

This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]

SLC39A2 基因产物(2)

mRNA Protein Name
NM_001256588.2 NP_001243517.1 zinc transporter ZIP2 isoform b
NM_014579.4 NP_055394.2 zinc transporter ZIP2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metal ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
29791142 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
29791142 GOA
enables zinc ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
20148757 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cadmium ion transmembrane transport IDA
IDA: 通过直接分析推断
29791142 GOA
involved in zinc ion transmembrane transport IDA
IDA: 通过直接分析推断
29791142 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
20148757 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC39A2 蛋白结构

Zip

Zip: ZIP Zinc transporter (6 - 306)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

zinc transporter ZIP2

ZRT/IRT-like protein 2

SLC39A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC39A2 Q9NP94 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra SLC39A2 Q9NP94 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra SLC39A2 Q9NP94 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SLC39A2 Q9NP94 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra SLC39A2 Q9NP94 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra SLC39A2 Q9NP94 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra SLC39A2 Q9NP94 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra SLC39A2 Q9NP94 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 TRHR Homo sapiens P34981
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 TRHR Homo sapiens P34981
Y2H Array
32296183
Intra SLC39A2 Q9NP94 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra SLC39A2 Q9NP94 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra SLC39A2 Q9NP94 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra SLC39A2 Q9NP94 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra SLC39A2 Q9NP94 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra SLC39A2 Q9NP94 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra SLC39A2 Q9NP94 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra SLC39A2 Q9NP94 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra SLC39A2 Q9NP94 LY6G6C Homo sapiens O95867
Y2H Prey Pooling
32296183
Intra SLC39A2 Q9NP94 LY6G6C Homo sapiens O95867
Y2H Array
32296183
Intra SLC39A2 Q9NP94 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Carotid Artery Disease

Carotid Artery Diseases

Disorder Of Carotid Artery

Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC39A2 MGD MGI:2684326
Rattus norvegicus SLC39A2 RGD RGD:1306291
Bos taurus SLC39A2 VGNC VGNC:34863
Canis familiaris SLC39A2 VGNC VGNC:46403
Felis catus SLC39A2 VGNC VGNC:65359