2. Gene
  3. SLC7A1 - solute carrier family 7 member 1 Gene

SLC7A1 - solute carrier family 7 member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 7 成员 1

种属: Homo sapiens

同用名: ERR; ATRC1; CAT-1; HCAT1; REC1L

基因 ID: 6541 | 基因类型: protein coding

关于 SLC7A1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:29,509,414-29,595,688 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 22.4), brain (RPKM 11.3) and 24 other tissues.

功能概要

启用 L-精氨酸跨膜转运蛋白活性和 L-组氨酸跨膜转运蛋白活性。参与氨基酸转运。位于膜内。顶端质膜的一部分；基底外侧质膜；和含蛋白质的复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables L-arginine transmembrane transporter activity and L-histidine transmembrane transporter activity. Involved in amino acid transport. Located in membrane. Part of apical plasma membrane; basolateral plasma membrane; and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A1 基因产物(1)

mRNA Protein Name
NM_003045.5 NP_003036.1 high affinity cationic amino acid transporter 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-arginine transmembrane transporter activity IDA
IDA: 通过直接分析推断
9174363 GOA
enables L-arginine transmembrane transporter activity IMP
IMP: 通过突变表型推断
26449889 GOA
enables L-histidine transmembrane transporter activity IDA
IDA: 通过直接分析推断
11591158 GOA
enables L-lysine transmembrane transporter activity IDA
IDA: 通过直接分析推断
10485994 GOA
enables amino acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
28684763 GOA
enables basic amino acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
11891586 GOA
enables basic amino acid transmembrane transporter activity IMP
IMP: 通过突变表型推断
17197568 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-amino acid transport IDA
IDA: 通过直接分析推断
28684763 GOA
involved in L-arginine transmembrane transport IDA
IDA: 通过直接分析推断
9174363 GOA
involved in L-arginine transmembrane transport IMP
IMP: 通过突变表型推断
26449889 GOA
involved in L-histidine import across plasma membrane IDA
IDA: 通过直接分析推断
11591158 GOA
involved in amino acid import across plasma membrane IDA
IDA: 通过直接分析推断
28684763 GOA
involved in lysine transport IDA
IDA: 通过直接分析推断
11891586 GOA
involved in ornithine transport IMP
IMP: 通过突变表型推断
17197568 GOA
acts upstream of positive regulation of T cell proliferation IMP
IMP: 通过突变表型推断
26449889 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
31791063 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11891586 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
28112518 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
28246125 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC7A1 蛋白结构

AA_permease_2

AA_permease_2: Amino acid permease (32 - 437)

AA_permease_C

AA_permease_C: C-terminus of AA_permease (558 - 608)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 629 a.a.
蛋白主名 其他名称

high affinity cationic amino acid transporter 1

CAT1

SLC7A1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC7A1 P30825 CCL4L1 Homo sapiens Q8NHW4
Validated Y2H
32296183
Intra SLC7A1 P30825 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Intra SLC7A1 P30825 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra SLC7A1 P30825 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra SLC7A1 P30825 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra SLC7A1 P30825 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra SLC7A1 P30825 MS4A13 Homo sapiens Q5J8X5
Validated Y2H
32296183
Intra SLC7A1 P30825 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
Intra SLC7A1 P30825 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra SLC7A1 P30825 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra SLC7A1 P30825 SLC52A1 Homo sapiens Q9NWF4
Validated Y2H
32296183
Intra SLC7A1 P30825 ST6GAL2 Homo sapiens Q96JF0-2
Validated Y2H
32296183
Intra SLC7A1 P30825 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SLC7A1 P30825 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra SLC7A1 P30825 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra SLC7A1 P30825 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra SLC7A1 P30825 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
Intra SLC7A1 P30825 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra SLC7A1 P30825 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra SLC7A1 P30825 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra SLC7A1 P30825 SLC18A2 Homo sapiens Q05940
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 SLC18A2 Homo sapiens Q05940
Y2H Array
32296183
Intra SLC7A1 P30825 SLC18A2 Homo sapiens Q05940
Validated Y2H
32296183
Intra SLC7A1 P30825 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra SLC7A1 P30825 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra SLC7A1 P30825 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra SLC7A1 P30825 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 CMTM2 Homo sapiens Q8TAZ6
Validated Y2H
32296183
Intra SLC7A1 P30825 CMTM2 Homo sapiens Q8TAZ6
Y2H Array
32296183
Intra SLC7A1 P30825 CMTM2 Homo sapiens Q8TAZ6
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 RNF144A Homo sapiens P50876
Validated Y2H
32296183
Intra SLC7A1 P30825 RNF144A Homo sapiens P50876
Y2H Array
32296183
Intra SLC7A1 P30825 RNF144A Homo sapiens P50876
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra SLC7A1 P30825 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra SLC7A1 P30825 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra SLC7A1 P30825 EMC6 Homo sapiens Q9BV81
Validated Y2H
32296183
Intra SLC7A1 P30825 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra SLC7A1 P30825 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 HERPUD2 Homo sapiens Q9BSE4
Validated Y2H
32296183
Intra SLC7A1 P30825 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
Intra SLC7A1 P30825 SACM1L Homo sapiens Q9NTJ5
Validated Y2H
32296183
Intra SLC7A1 P30825 GALNT15 Homo sapiens Q8N3T1
Validated Y2H
32296183
Intra SLC7A1 P30825 STIM1 Homo sapiens Q13586
Validated Y2H
32296183
Intra SLC7A1 P30825 STIM1 Homo sapiens Q13586
Y2H Array
32296183
Intra SLC7A1 P30825 STIM1 Homo sapiens Q13586
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra SLC7A1 P30825 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra SLC7A1 P30825 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra SLC7A1 P30825 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
Intra SLC7A1 P30825 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra SLC7A1 P30825 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra SLC7A1 P30825 PTPN9 Homo sapiens P43378
Validated Y2H
32296183
Intra SLC7A1 P30825 PTPN9 Homo sapiens P43378
Y2H Array
32296183
Intra SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra SLC7A1 P30825 YIPF4 Homo sapiens Q9BSR8
Anti Tag CoIP
28514442
Intra SLC7A1 P30825 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
Intra SLC7A1 P30825 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra SLC7A1 P30825 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra SLC7A1 P30825 SEC23A Homo sapiens Q15436
Validated Y2H
32296183
Intra SLC7A1 P30825 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra SLC7A1 P30825 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra SLC7A1 P30825 PNLIPRP1 Homo sapiens P54315
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Aids Phobia
Tinea Capitis

Dermatophytosis Of Scalp

Scalp Ringworm

Dermatophytosis Of Scalp Or Beard

Tinea Capitis Due To Trichophyton Rubrum

Trichophyton Rubrum Tinea Capitis
Decubitus Ulcer

Pressure Ulcer

Pressure Sores

Pressure Ulcers

Bedsore

Decubitus Ulcer

Decubitus Ulcer Any Site
Prolapse Of Urethra

Urethrocele
Chronic Ulcer Of Skin

Chronic Wounds

Callous Ulcer

Indolent Ulcer

Chronic Ulcer
Dermatophytosis

Tinea

Dermatophytosis, Unspecified

Ringworm

Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

Cutaneous Mycosis

Dermal Mycosis

Superficial Mycosis, Unspecified

Fungus Infection Of Skin

Skin Mycosis

Dermatitis Fungoid

Fungal Dermatitis

Fungal Dermatosis

Mycotic Infection Of Skin
Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis
Subacute Leukemia
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13323 SLC7A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SLC7A1 VGNC VGNC:77626
Mus musculus SLC7A1 MGD MGI:88117
Bos taurus SLC7A1 VGNC VGNC:34924
Canis familiaris SLC7A1 VGNC VGNC:46470
Felis catus SLC7A1 VGNC VGNC:65421
Rattus norvegicus SLC7A1 RGD RGD:3716
Others SLC7A1 NCBI
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