2. Gene
  3. SEC23A - SEC23 homolog A, COPII coat complex component Gene

SEC23A - SEC23 homolog A, COPII coat complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SEC23 同系物 A，COPII 涂层复杂成分

种属: Homo sapiens

同用名: CLSD; hSec23A

基因 ID: 10484 | 基因类型: protein coding

关于 SEC23A

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:39,031,919-39,103,235 (from NCBI)

This gene has 15 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 27.6), small intestine (RPKM 25.4) and 24 other tissues.

功能概要

该基因编码的蛋白质是 SEC23/SEC24 家族的 SEC23 亚家族成员。它是蛋白质复合物的一部分，存在于内质网 (ER) 和相关囊泡的无核糖体过渡面中。该蛋白与 COPII 的酵母 Sec23p 成分具有相似性。 COPII 是负责囊泡从 ER 出芽的外壳蛋白复合物。编码的蛋白质被认为在 ER-高尔基体蛋白质运输中发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

SEC23A 基因产物(1)

mRNA Protein Name
NM_006364.4 NP_006355.2 protein transport protein Sec23A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10075675 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
18843296 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in COPII-coated vesicle cargo loading IDA
IDA: 通过直接分析推断
17499046 GOA
involved in COPII-coated vesicle cargo loading IGI
IGI: 通过遗传相互作用推断
8898360 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COPII vesicle coat IDA
IDA: 通过直接分析推断
17499046 GOA
located in ER to Golgi transport vesicle membrane IGI
IGI: 通过遗传相互作用推断
8898360 GOA
located in cytosol IDA
IDA: 通过直接分析推断
8898360 GOA
located in endoplasmic reticulum exit site IDA
IDA: 通过直接分析推断
8898360 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEC23A 蛋白结构

zf-Sec23_Sec24

zf-Sec23_Sec24: Sec23/Sec24 zinc finger (57 - 98)

Sec23_trunk

Sec23_trunk: Sec23/Sec24 trunk domain (126 - 390)

Sec23_BS

Sec23_BS: Sec23/Sec24 beta-sandwich domain (401 - 504)

Sec23_helical

Sec23_helical: Sec23/Sec24 helical domain (519 - 619)

Gelsolin

Gelsolin: Gelsolin repeat (631 - 718)

  • 0
  • 200
  • 400
  • 600
  • 765 a.a.
蛋白主名 其他名称

protein transport protein Sec23A

SEC23-related protein A

SEC23A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SEC23A Q15436 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
种属内
SEC23A Q15436 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
种属内
SEC23A Q15436 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
种属内
SEC23A Q15436 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
种属内
SEC23A Q15436 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
种属内
SEC23A Q15436 MINAR1 Homo sapiens Q9UPX6
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 MINAR1 Homo sapiens Q9UPX6
Validated Y2H
32296183
种属内
SEC23A Q15436 MINAR1 Homo sapiens Q9UPX6
Y2H Array
32296183
种属内
SEC23A Q15436 SF1 Homo sapiens Q15637-4
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 SF1 Homo sapiens Q15637-4
Validated Y2H
32296183
种属内
SEC23A Q15436 SF1 Homo sapiens Q15637-4
Y2H Array
32296183
种属内
SEC23A Q15436 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 GJA8 Homo sapiens P48165
Y2H Array
32296183
种属内
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Y2H Array
32296183
种属内
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Validated Y2H
32296183
种属内
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Anti Tag CoIP
33961781
种属内
SEC23A Q15436 SUCLA2 Homo sapiens Q9P2R7
Validated Y2H
32296183
种属内
SEC23A Q15436 MIA3 Homo sapiens Q5JRA6
Validated Y2H
32296183
种属内
SEC23A Q15436 MIA3 Homo sapiens Q5JRA6
Y2H Array
32296183
种属内
SEC23A Q15436 MIA3 Homo sapiens Q5JRA6
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
种属内
SEC23A Q15436 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
种属内
SEC23A Q15436 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 DNM2 Homo sapiens P50570
Y2H Array
32296183
种属内
SEC23A Q15436 DNM2 Homo sapiens P50570
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
种属内
SEC23A Q15436 ERLIN1 Homo sapiens O75477
Y2H Array
32296183
种属内
SEC23A Q15436 ERLIN1 Homo sapiens O75477
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
种属内
SEC23A Q15436 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
种属内
SEC23A Q15436 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
种属内
SEC23A Q15436 FASLG Homo sapiens P48023
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 FASLG Homo sapiens P48023
Y2H Array
32296183
种属内
SEC23A Q15436 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
种属内
SEC23A Q15436 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 WBP11 Homo sapiens Q9Y2W2
Validated Y2H
32296183
种属内
SEC23A Q15436 WBP11 Homo sapiens Q9Y2W2
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 WBP11 Homo sapiens Q9Y2W2
Y2H Array
32296183
种属内
SEC23A Q15436 CDK16 Homo sapiens Q00536
Anti Bait CoIP
16091426
种属内
SEC23A Q15436 CDK16 Homo sapiens Q00536
Y2H
16091426
种属内
SEC23A Q15436 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
种属内
SEC23A Q15436 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
种属内
SEC23A Q15436 SEC23B Homo sapiens Q15437
Validated Y2H
32296183
种属内
SEC23A Q15436 SEC23B Homo sapiens Q15437
Anti Tag CoIP
33961781
种属内
SEC23A Q15436 SEC23B Homo sapiens Q15437
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 SEC23B Homo sapiens Q15437
Y2H Array
32296183
种属内
SEC23A Q15436 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
种属内
SEC23A Q15436 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
种属内
SEC23A Q15436 SEC24D Homo sapiens O94855
Anti Tag CoIP
33961781
种属内
SEC23A Q15436 SEC24D Homo sapiens O94855
Anti Tag CoIP
35271311
种属内
SEC23A Q15436 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 BNIP3 Homo sapiens Q12983
Y2H Array
32296183
种属内
SEC23A Q15436 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
种属内
SEC23A Q15436 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属内
SEC23A Q15436 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
种属内
SEC23A Q15436 SEC24B Homo sapiens O95487
Anti Tag CoIP
35271311
种属内
SEC23A Q15436 SEC24B Homo sapiens O95487
Anti Tag CoIP
33961781
种属内
SEC23A Q15436 SEC24C Homo sapiens P53992
Cosedimentation
18692470
种属内
SEC23A Q15436 SEC24C Homo sapiens P53992
Anti Tag CoIP
33961781
种属内
SEC23A Q15436 SEC24C Homo sapiens P53992
EM
18692470
种属内
SEC23A Q15436 SEC24C Homo sapiens P53992
Y2H
10075675
种属间: 跨种属相互作用 种属内: 同种属相互作用

SEC23A 抗体

目录号 产品名 应用 反应物种
HY-P81799 SEC23A Antibody (YA1544) WB, FC Human

关联疾病

疾病名称 别名
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia Tarda

SEDT

Sed Tarda, X-Linked

Spondyloepiphyseal Dysplasia, Late

Spondyloepiphyseal Dysplasia Tarda X-Linked

Sed

X Linked Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia

Late Onset Spondyloepiphyseal Dysplasia

Sed Tarda

X-Linked Sed

X-Linked Sedt

Dysplasia, Spondyloepiphyseal, Tarda

Spondyloepiphyseal Dysplasia
Anemia, Congenital Dyserythropoietic, Type Ii

Congenital Dyserythropoietic Anemia Type Ii

CDAN2

Cda Ii

Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test

Cda Type Ii

Congenital Dyserythropoietic Anemia Type 2

Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test

Sec23b-Cdg

Congenital Dyserythropoietic Anemia, Type Ii

Dyserythropoietic Anemia, Hempas Type

Hempas

Cda Type 2

Dyserythropoietic Anemia, Congenital, Type Ii

Cda, Type Ii

Congenital Dyserythropoietic Anaemia Type 2

Congenital Dyserythropoietic Anaemia Type Ii

Anemia, Dyserythropoietic, Congenital Type 2

Hempas Anemia

Dyserythropoietic Anemia, Congenital Type 2

Anemia, Congenital Dyserythropoietic, 2

Dyserythropoietic Anemia Hempas Type

Anemia, Dyserythropoietic Congenital, Type Ii

Anemia, Dyserythropoietic, Congenital, Type Ii
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome

Catshl Syndrome

Camptodactyly-Tall Stature-Scoliosis-Deafness Syndrome
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome

Smed-Sl

Smed-Sl/Ac

Smed Short Limb-Abnormal Calcification Type

Smed Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia Short Limb-Hand Type

Smed, Type Ii

Smed Type 2

Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type

Smed, Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type

Smed, Short Limb-Abnormal Calcification Type

Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification

Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type

SEMD-SL

Smed Type Ii

Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Cole-Carpenter Syndrome

Cole Carpenter Syndrome

Bone Fragility Craniosynostosis Proptosis Hydrocephalus

Bone Fragility With Craniosynostosis, Ocular Proptosis, Hydrocephalus, And Distinctive Facial Features

Bone Fragility-Craniosynostosis-Proptosis-Hydrocephalus Syndrome
Spondyloepiphyseal Dysplasia Congenita

SEDC

Sed Congenita

Spondyloepiphyseal Dysplasia, Congenital Type

Late Spondyloepiphyseal Dysplasia

Sed, Congenital Type

Congenital Spondyloepiphyseal Dysplasia

Spranger-Wiedemann Disease

Spondyloepiphyseal Dysplasia Congenital Type

Dysplasia, Spondyloepiphyseal, Congenita

Spondyloepiphyseal Dysplasia, Congenita

Spondyloepiphyseal Dysplasia Tarda, X-Linked
Geroderma Osteodysplasticum

Gerodermia Osteodysplastica

Geroderma Osteodysplastica

GO

Walt Disney Dwarfism

Type Of Gerodermia Osteodysplastica
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12612 SEC23A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SEC23A RGD RGD:1309103
Bos taurus SEC23A VGNC VGNC:34410
Canis familiaris SEC23A VGNC VGNC:45969
Mus musculus SEC23A MGD MGI:1349635
Felis catus SEC23A VGNC VGNC:64966
Macaca mulatta SEC23A VGNC VGNC:77150
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z