2. Gene
  3. SEC24C - SEC24 homolog C, COPII coat complex component Gene

SEC24C - SEC24 homolog C, COPII coat complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SEC24 同系物 C，COPII 涂层复杂成分

种属: Homo sapiens

基因 ID: 9632 | 基因类型: protein coding

关于 SEC24C

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,744,372-73,772,161 (from NCBI)

This gene has 7 transcripts (splice variants), 42 orthologues and is associated with 1 phenotype. Ubiquitous expression in esophagus (RPKM 30.5), thyroid (RPKM 29.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是 SEC23/SEC24 家族的 SEC24 亚家族成员，参与囊泡运输。编码的蛋白质与 COPII 的酵母 Sec24p 成分具有相似性。 COPII 是负责囊泡从 ER 出芽的外壳蛋白复合物。该基因的产物可能在形成囊泡以及货物选择和集中方面发挥作用。已经鉴定出编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

SEC24C 基因产物(2)

mRNA Protein Name
NM_004922.4 NP_004913.2 protein transport protein Sec24C
NM_198597.3 NP_940999.1 protein transport protein Sec24C
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SNARE binding IPI
IPI: 通过物理相互作用推断
18843296 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10075675 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
18843296 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in COPII-coated vesicle cargo loading IDA
IDA: 通过直接分析推断
17499046 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
20427317 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COPII vesicle coat IDA
IDA: 通过直接分析推断
10075675 GOA
located in cytosol IDA
IDA: 通过直接分析推断
10075675 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEC24C 蛋白结构

zf-Sec23_Sec24

zf-Sec23_Sec24: Sec23/Sec24 zinc finger (421 - 460)

Sec23_trunk

Sec23_trunk: Sec23/Sec24 trunk domain (499 - 743)

Sec23_BS

Sec23_BS: Sec23/Sec24 beta-sandwich domain (748 - 831)

Sec23_helical

Sec23_helical: Sec23/Sec24 helical domain (845 - 945)

Gelsolin

Gelsolin: Gelsolin repeat (962 - 1034)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1094 a.a.
蛋白主名 其他名称

protein transport protein Sec24C

SEC24 family, member C

SEC24C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SEC24C P53992 MOS Homo sapiens P00540
Validated Y2H
25416956
Intra SEC24C P53992 MOS Homo sapiens P00540
Y2H Array
25416956
Intra SEC24C P53992 MOS Homo sapiens P00540
Y2H Array
31515488
Intra SEC24C P53992 SEC23B Homo sapiens Q15437
Y2H Pooling
16189514
Intra SEC24C P53992 SEC23B Homo sapiens Q15437
Y2H Array
31515488
Intra SEC24C P53992 SEC23B Homo sapiens Q15437
Anti Tag CoIP
35271311
Intra SEC24C P53992 SEC23A Homo sapiens Q15436
CoIP
10075675
Intra SEC24C P53992 SEC23A Homo sapiens Q15436
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Anemia, Congenital Dyserythropoietic, Type Ii

Congenital Dyserythropoietic Anemia Type Ii

CDAN2

Cda Ii

Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test

Cda Type Ii

Congenital Dyserythropoietic Anemia Type 2

Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test

Sec23b-Cdg

Congenital Dyserythropoietic Anemia, Type Ii

Dyserythropoietic Anemia, Hempas Type

Hempas

Cda Type 2

Dyserythropoietic Anemia, Congenital, Type Ii

Cda, Type Ii

Congenital Dyserythropoietic Anaemia Type 2

Congenital Dyserythropoietic Anaemia Type Ii

Anemia, Dyserythropoietic, Congenital Type 2

Hempas Anemia

Dyserythropoietic Anemia, Congenital Type 2

Anemia, Congenital Dyserythropoietic, 2

Dyserythropoietic Anemia Hempas Type

Anemia, Dyserythropoietic Congenital, Type Ii

Anemia, Dyserythropoietic, Congenital, Type Ii
Chylomicron Retention Disease

CMRD

Anderson Disease

Lipid Transport Defect Of Intestine

Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

Andd

Anderson Syndrome

Crd

Andersons Disease

Malabsorption Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12617 SEC24C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SEC24C VGNC VGNC:64969
Mus musculus SEC24C MGD MGI:1919746
Canis familiaris SEC24C VGNC VGNC:45974
Bos taurus SEC24C VGNC VGNC:34415
Macaca mulatta SEC24C VGNC VGNC:77153
Rattus norvegicus SEC24C RGD RGD:1597739
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