1. Gene
  2. MOS - MOS proto-oncogene, serine/threonine kinase Gene

MOS - MOS proto-oncogene, serine/threonine kinase Gene

中文名称:MOS 原癌基因,丝氨酸/苏氨酸激酶

种属: Homo sapiens

同用名: MSV

基因 ID: 4342 | 基因类型: protein coding

关于 MOS

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,112,942-56,113,982 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 23 paralogues.

功能概要

MOS 是一种丝氨酸/苏氨酸激酶,通过 MAP 激酶激活剂 MEK (MAP2K1;MIM 176872) 的直接磷酸化激活 MAP 激酶级联 (Prasad 等人,2008 [PubMed 18246541]) 。[OMIM 提供,2009 年 7 月]

MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

MOS 基因产物(1)

mRNA Protein Name
NM_005372.1 NP_005363.1 proto-oncogene serine/threonine-protein kinase mos
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in oocyte maturation IMP
IMP: 通过突变表型推断
34779126 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
34779126 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IMP
IMP: 通过突变表型推断
35670744 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MOS 蛋白结构

Pkinase

Pkinase: Protein kinase domain (62 - 335)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
蛋白主名 其他名称

proto-oncogene serine/threonine-protein kinase mos

c-mos

MOS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MOS P00540 CCDC136 Homo sapiens Q96JN2-2
Validated Y2H
25416956
种属内
MOS P00540 KRT13 Homo sapiens A1A4E9
Y2H Array
25416956
种属内
MOS P00540 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
种属内
MOS P00540 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
种属内
MOS P00540 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
25416956
种属内
MOS P00540 BORCS6 Homo sapiens Q96GS4
Validated Y2H
25416956
种属内
MOS P00540 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
种属内
MOS P00540 KRT34 Homo sapiens O76011
Y2H Array
32296183
种属内
MOS P00540 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
种属内
MOS P00540 KRT33B Homo sapiens Q14525
Y2H Array
32296183
种属内
MOS P00540 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
种属内
MOS P00540 PSTPIP1 Homo sapiens O43586
Y2H Array
32296183
种属内
MOS P00540 PSTPIP1 Homo sapiens O43586
Y2H Prey Pooling
32296183
种属内
MOS P00540 MAP2K2 Homo sapiens P36507
Y2H Array
32296183
种属内
MOS P00540 MAP2K2 Homo sapiens P36507
Y2H Prey Pooling
32296183
种属内
MOS P00540 MAP2K2 Homo sapiens P36507
Validated Y2H
32296183
种属内
MOS P00540 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
种属内
MOS P00540 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
种属内
MOS P00540 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
种属内
MOS P00540 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
种属内
MOS P00540 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
种属内
MOS P00540 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
种属内
MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
种属内
MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
30886144
种属内
MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
种属内
MOS P00540 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
种属内
MOS P00540 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
种属内
MOS P00540 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
种属内
MOS P00540 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
种属内
MOS P00540 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
种属内
MOS P00540 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
种属内
MOS P00540 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
种属内
MOS P00540 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
种属内
MOS P00540 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
种属内
MOS P00540 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
种属内
MOS P00540 BICD2 Homo sapiens Q8TD16-2
Validated Y2H
32296183
种属内
MOS P00540 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
种属内
MOS P00540 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
MOS P00540 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
MOS P00540 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
MOS P00540 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
种属内
MOS P00540 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
种属内
MOS P00540 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
种属内
MOS P00540 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
MOS P00540 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
种属内
MOS P00540 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
MOS P00540 KCTD6 Homo sapiens Q8NC69
Validated Y2H
32296183
种属内
MOS P00540 KCTD6 Homo sapiens Q8NC69
Y2H Array
32296183
种属内
MOS P00540 KCTD6 Homo sapiens Q8NC69
Y2H Prey Pooling
32296183
种属内
MOS P00540 ZBTB2 Homo sapiens Q8N680
Y2H Array
32296183
种属内
MOS P00540 ZBTB2 Homo sapiens Q8N680
Y2H Prey Pooling
32296183
种属内
MOS P00540 ZBTB2 Homo sapiens Q8N680
Validated Y2H
32296183
种属内
MOS P00540 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
32296183
种属内
MOS P00540 MIPOL1 Homo sapiens Q8TD10
Y2H Array
32296183
种属内
MOS P00540 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
32296183
种属内
MOS P00540 CDC37 Homo sapiens Q16543
Pull Down
32707033
种属内
MOS P00540 HSP90AA1 Homo sapiens P07900
Pull Down
32707033
种属内
MOS P00540 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
种属内
MOS P00540 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
种属内
MOS P00540 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
种属内
MOS P00540 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
33961781
种属内
MOS P00540 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
28514442
种属内
MOS P00540 FKBP5 Homo sapiens Q13451
Lumier
25036637
种属内
MOS P00540 FKBP5 Homo sapiens Q13451
Pull Down
32707033
种属内
MOS P00540 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
MOS P00540 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
MOS P00540 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
种属内
MOS P00540 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
种属内
MOS P00540 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
种属内
MOS P00540 STUB1 Homo sapiens Q9UNE7
Pull Down
32707033
种属内
MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
种属内
MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
种属内
MOS P00540 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
种属内
MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
种属内
MOS P00540 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
种属内
MOS P00540 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
种属内
MOS P00540 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
种属内
MOS P00540 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
种属内
MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
种属内
MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
MOS P00540 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
种属内
MOS P00540 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
种属内
MOS P00540 PPP2R5A Homo sapiens Q15172
Pull Down
32707033
种属内
MOS P00540 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
28514442
种属内
MOS P00540 PPP2R5A Homo sapiens Q15172
Y2H Prey Pooling
32296183
种属内
MOS P00540 PPP2R5A Homo sapiens Q15172
Validated Y2H
32296183
种属内
MOS P00540 PPP2R5A Homo sapiens Q15172
Y2H Array
32296183
种属内
MOS P00540 ASB6 Homo sapiens Q9NWX5
Y2H Prey Pooling
32296183
种属内
MOS P00540 ASB6 Homo sapiens Q9NWX5
Validated Y2H
32296183
种属内
MOS P00540 ASB6 Homo sapiens Q9NWX5
Y2H Array
32296183
种属内
MOS P00540 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
种属内
MOS P00540 KRT15 Homo sapiens P19012
Validated Y2H
25416956
种属内
MOS P00540 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
种属内
MOS P00540 KRT15 Homo sapiens P19012
Validated Y2H
32296183
种属内
MOS P00540 KRT15 Homo sapiens P19012
Y2H Array
32296183
种属内
MOS P00540 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
种属内
MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
种属内
MOS P00540 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
种属内
MOS P00540 CALCOCO2 Homo sapiens Q13137
Validated Y2H
32296183
种属内
MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
种属内
MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
种属内
MOS P00540 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
种属内
MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
种属内
MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
种属内
MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
种属内
MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
种属内
MOS P00540 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
种属内
MOS P00540 GRAP2 Homo sapiens O75791
Y2H Array
32296183
种属内
MOS P00540 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
32296183
种属内
MOS P00540 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
25416956
种属内
MOS P00540 DYDC1 Homo sapiens Q8WWB3
Y2H Array
25416956
种属内
MOS P00540 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
种属内
MOS P00540 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
种属内
MOS P00540 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
种属内
MOS P00540 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
种属内
MOS P00540 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
种属内
MOS P00540 GFAP Homo sapiens P14136
Y2H Prey Pooling
25416956
种属内
MOS P00540 MTMR9 Homo sapiens Q96QG7
Y2H Array
31515488
种属内
MOS P00540 MTMR9 Homo sapiens Q96QG7
Y2H Array
25416956
种属内
MOS P00540 MTMR9 Homo sapiens Q96QG7
Y2H Array
29892012
种属内
MOS P00540 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
种属内
MOS P00540 ATRIP Homo sapiens Q8WXE1
Y2H Prey Pooling
25416956
种属内
MOS P00540 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
种属内
MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H Array
25416956
种属内
MOS P00540 HOMER3 Homo sapiens Q9NSC5
Complementation
32296183
种属内
MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
种属内
MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H
21516116
种属内
MOS P00540 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
25416956
种属内
MOS P00540 ACTN2 Homo sapiens P35609
Y2H Array
25416956
种属内
MOS P00540 ACTN2 Homo sapiens P35609
Validated Y2H
25416956
种属内
MOS P00540 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
25416956
种属内
MOS P00540 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属内
MOS P00540 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属内
MOS P00540 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属内
MOS P00540 SEC24C Homo sapiens P53992
Y2H Prey Pooling
25416956
种属内
MOS P00540 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属内
MOS P00540 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属内
MOS P00540 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
种属内
MOS P00540 KIFAP3 Homo sapiens Q92845
Validated Y2H
32296183
种属内
MOS P00540 KIFAP3 Homo sapiens Q92845
Y2H Array
32296183
种属内
MOS P00540 KIFAP3 Homo sapiens Q92845
Y2H Prey Pooling
32296183
种属内
MOS P00540 DZIP1 Homo sapiens Q86YF9
Y2H Prey Pooling
32296183
种属内
MOS P00540 DZIP1 Homo sapiens Q86YF9
Validated Y2H
32296183
种属内
MOS P00540 DZIP1 Homo sapiens Q86YF9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus MOS VGNC VGNC:68300
Bos taurus MOS VGNC VGNC:31563
Rattus norvegicus MOS RGD RGD:3103
Macaca mulatta MOS VGNC VGNC:74911
Mus musculus MOS MGD MGI:97052
Canis familiaris MOS VGNC VGNC:43323
Macaca fascicularis MOS NCBI NCBI:102119783
Others MOS NCBI