2. Gene
  3. GRAP2 - GRB2 related adaptor protein 2 Gene

GRAP2 - GRB2 related adaptor protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：GRB2 相关衔接蛋白 2

种属: Homo sapiens

同用名: P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2

基因 ID: 9402 | 基因类型: protein coding

关于 GRAP2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,893,820-39,973,721 (from NCBI)

This gene has 7 transcripts (splice variants), 260 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 6.7), spleen (RPKM 4.1) and 17 other tissues.

功能概要

该基因编码 GRB2/Sem5/Drk 家族的一个成员。该成员是一种参与白细胞特异性蛋白-酪氨酸激酶信号转导的衔接子样蛋白。与其相关的家族成员 GRB2 相关衔接蛋白 (GRAP) 一样，该蛋白包含一个 SH2 结构域，两侧是两个 SH3 结构域。该蛋白通过其 SH3 结构域与其他蛋白相互作用，例如 GRB2 相关结合蛋白 1 (GAB1) 和 SLP-76 白细胞蛋白 (LCP2) 。已经为该基因发现了编码不同亚型的多个选择性剪接的转录物变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GRAP2 基因产物(5)

mRNA Protein Name
NM_001291824.2 NP_001278753.1 GRB2-related adapter protein 2 isoform 1
NM_001291825.1 NP_001278754.1 GRB2-related adapter protein 2 isoform 1
NM_001291826.2 NP_001278755.1 GRB2-related adapter protein 2 isoform 2
NM_001291828.2 NP_001278757.1 GRB2-related adapter protein 2 isoform 3
NM_004810.4 NP_004801.1 GRB2-related adapter protein 2 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12359715 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21179510 GOA
located in endosome IDA
IDA: 通过直接分析推断
21179510 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21179510 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRAP2 蛋白结构

SH3_1

SH3_1: SH3 domain (4 - 47)

SH2

SH2: SH2 domain (58 - 132)

SH3_1

SH3_1: SH3 domain (277 - 322)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
蛋白主名 其他名称

GRB2-related adapter protein 2

GRB-2-like protein

GRAP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GRAP2 O75791 ZNF250 Homo sapiens P15622-3
Validated Y2H
32296183
Intra GRAP2 O75791 ZSCAN21 Homo sapiens Q9Y5A6
Anti Tag CoIP
33961781
Intra GRAP2 O75791 ZSCAN21 Homo sapiens Q9Y5A6
Anti Tag CoIP
28514442
Intra GRAP2 O75791 ZSCAN21 Homo sapiens Q9Y5A6
Validated Y2H
32296183
Intra GRAP2 O75791 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra GRAP2 O75791 PRR35 Homo sapiens P0CG20
Validated Y2H
32296183
Intra GRAP2 O75791 ZNF319 Homo sapiens Q9P2F9
Validated Y2H
32296183
Intra GRAP2 O75791 KIT Homo sapiens P10721
FPS
24728074
Intra GRAP2 O75791 PRKAA2 Homo sapiens P54646
Validated Y2H
32296183
Cross GRAP2 O75791 Kcnma1 Mus musculus Q08460
Protein Array
17065230
Intra GRAP2 O75791 MOS Homo sapiens P00540
Validated Y2H
32296183
Intra GRAP2 O75791 RAVER1 Homo sapiens Q8IY67
Validated Y2H
32296183
Intra GRAP2 O75791 EGFR Homo sapiens P00533
Lumier
24658140
Intra GRAP2 O75791 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
Intra GRAP2 O75791 EGFR Homo sapiens P00533
Ub Reconstruction
31980649
Intra GRAP2 O75791 GAREM1 Homo sapiens Q9H706
Validated Y2H
32296183
Intra GRAP2 O75791 GAREM1 Homo sapiens Q9H706
Anti Tag CoIP
33961781
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
X-Ray Diffraction
17010654
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Validated Y2H
32296183
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Anti Tag CoIP
17235283
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Lumier
37398436
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
MAPPIT
32296183
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
SPR
17235283
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Y2H Array
25416956
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
Complementation
32296183
Intra GRAP2 O75791 LCP2 Homo sapiens Q13094
BFG-2H
27107012
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Y2H
16730941
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Y2H Array
31515488
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Anti Tag CoIP
33961781
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Y2H Pooling
16189514
Intra GRAP2 O75791 STAMBP Homo sapiens O95630
Anti Tag CoIP
28514442
Intra GRAP2 O75791 GAB1 Homo sapiens Q13480
Pull Down
10913131
Intra GRAP2 O75791 GAB1 Homo sapiens Q13480
Anti Tag CoIP
33961781
Intra GRAP2 O75791 GAB1 Homo sapiens Q13480
FPS
24728074
Intra GRAP2 O75791 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
Anti Tag CoIP
33961781
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
Far-WB
21179510
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
IF
21179510
Intra GRAP2 O75791 PTPN23 Homo sapiens Q9H3S7
Anti Tag CoIP
28514442
Intra GRAP2 O75791 LNX1 Homo sapiens Q8TBB1
BFG-2H
27107012
Intra GRAP2 O75791 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra GRAP2 O75791 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra GRAP2 O75791 PBLD Homo sapiens P30039
Validated Y2H
32296183
Intra GRAP2 O75791 q7z783_human Homo sapiens Q7Z783
Validated Y2H
32296183
Intra GRAP2 O75791 GAB2 Homo sapiens Q9UQC2
Anti Tag CoIP
33961781
Intra GRAP2 O75791 GAB2 Homo sapiens Q9UQC2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib

IGHD1B

Ighd Ib

Growth Hormone Deficiency, Isolated, Type Ib

Congenital Ighd Type Ib

Congenital Isolated Gh Deficiency Type Ib

Congenital Isolated Growth Hormone Deficiency Type Ib

Dwarfism Of Sindh

Pituitary Dwarfism I

Isolated Growth Hormone Deficiency Type 1b

Ighd 1b

Growth Hormone Deficiency, Isolated, 1b
Generalized Anxiety Disorder

Anxiety Generalized
Hypochondriasis

Hypochondriacal Disorder

Hypochondria

Hypochondriacal Neurosis

Illness Anxiety Disorder

Health Anxiety Disorder

Hypochondriacal Reaction
Somatization Disorder

Somatoform Disorders

Briquet'S Disorder

Polysomatising Disorder

Somatisation Disorder

Somatoform Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05776 GRAP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GRAP2 VGNC VGNC:73156
Canis familiaris GRAP2 VGNC VGNC:41470
Rattus norvegicus GRAP2 RGD RGD:1307605
Bos taurus GRAP2 VGNC VGNC:29627
Felis catus GRAP2 VGNC VGNC:67455
Mus musculus GRAP2 MGD MGI:1333842
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