1. Gene
  2. SPRY2 - sprouty RTK signaling antagonist 2 Gene

SPRY2 - sprouty RTK signaling antagonist 2 Gene

中文名称:发芽的 RTK 信号拮抗因子 2

种属: Homo sapiens

同用名: IGAN3; hSPRY2

基因 ID: 10253 | 基因类型: protein coding

关于 SPRY2

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:80,335,976-80,341,126 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues.

功能概要

该基因编码属于发芽家族的蛋白质。编码的蛋白质包含一个羧基末端富含半胱氨酸的结构域,该结构域对于受体酪氨酸激酶信号蛋白的抑制活性至关重要,并且是生长因子刺激蛋白质向膜褶皱易位所必需的。在原代真皮内皮细胞中,该基因响应成纤维细胞生长因子 2 而瞬时上调。该蛋白间接参与对成纤维细胞生长因子二信号传导的非细胞自主抑制作用。该蛋白与 Cas-Br-M (鼠类) 逆转录病毒转化序列相互作用,可作为表皮生长因子受体/丝裂原活化蛋白激酶信号转导的双峰调节剂发挥作用。这种蛋白质可能在肺发育过程中的肺泡分支中发挥作用,如类似的小鼠蛋白质所示。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to Fibroblast Growth Factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on Fibroblast Growth Factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

SPRY2 基因产物(4)

mRNA Protein Name
NM_001318536.1 NP_001305465.1 protein sprouty homolog 2
NM_001318537.1 NP_001305466.1 protein sprouty homolog 2
NM_001318538.1 NP_001305467.1 protein sprouty homolog 2
NM_005842.4 NP_005833.1 protein sprouty homolog 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12815057 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20736167 GOA
enables protein serine/threonine kinase activator activity IMP
IMP: 通过突变表型推断
18070883 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to vascular endothelial growth factor stimulus IDA
IDA: 通过直接分析推断
21536891 GOA
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
21536891 GOA
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
20489163 GOA
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
24177325 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
18070883 GOA
involved in negative regulation of peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
20736167 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
17974561 GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway IDA
IDA: 通过直接分析推断
21536891 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
18070883 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
20489163 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
18070883 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
18070883 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
18070883 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SPRY2 蛋白结构

Sprouty

Sprouty: Sprouty protein (Spry) (183 - 294)

  • 0
  • 100
  • 200
  • 315 a.a.
蛋白主名 其他名称

protein sprouty homolog 2

SPRY2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SPRY2 O43597 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
种属内
SPRY2 O43597 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
种属内
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
种属内
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
种属内
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
种属内
SPRY2 O43597 KRTAP9-4 Homo sapiens Q9BYQ2
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP10-11 Homo sapiens P60412
Validated Y2H
25416956
种属内
SPRY2 O43597 KRTAP10-11 Homo sapiens P60412
Y2H Array
25416956
种属内
SPRY2 O43597 RUNX1T1 Homo sapiens Q06455-4
Validated Y2H
25416956
种属内
SPRY2 O43597 PTGER3 Homo sapiens P43115-12
Y2H Array
25416956
种属内
SPRY2 O43597 PTGER3 Homo sapiens P43115-12
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 q5jpt6_human Homo sapiens Q5JPT6
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 q5jpt6_human Homo sapiens Q5JPT6
Y2H Array
25416956
种属内
SPRY2 O43597 LCE3C Homo sapiens Q5T5A8
Validated Y2H
25416956
种属内
SPRY2 O43597 LCE3C Homo sapiens Q5T5A8
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 LCE3E Homo sapiens Q5T5B0
Validated Y2H
25416956
种属内
SPRY2 O43597 LCE3E Homo sapiens Q5T5B0
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Y2H Array
29892012
种属内
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Y2H Array
31515488
种属内
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Validated Y2H
25416956
种属内
SPRY2 O43597 LCE4A Homo sapiens Q5TA78
Y2H Array
25416956
种属内
SPRY2 O43597 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 LCE2D Homo sapiens Q5TA82
Validated Y2H
25416956
种属内
SPRY2 O43597 LCE2D Homo sapiens Q5TA82
Y2H Array
25416956
种属内
SPRY2 O43597 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
25416956
种属内
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Array
25416956
种属内
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
25416956
种属内
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
25416956
种属内
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 SHFL Homo sapiens Q9NUL5
Validated Y2H
25416956
种属内
SPRY2 O43597 SHFL Homo sapiens Q9NUL5
Y2H Array
25416956
种属内
SPRY2 O43597 SHFL Homo sapiens Q9NUL5
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
种属内
SPRY2 O43597 PRKAB2 Homo sapiens O43741
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
种属内
SPRY2 O43597 UBASH3B Homo sapiens Q8TF42
Validated Y2H
25416956
种属内
SPRY2 O43597 GP9 Homo sapiens P14770
Y2H Array
25416956
种属内
SPRY2 O43597 GP9 Homo sapiens P14770
Validated Y2H
25416956
种属内
SPRY2 O43597 UBASH3A Homo sapiens P57075
Y2H Array
25416956
种属内
SPRY2 O43597 UBASH3A Homo sapiens P57075
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 UBASH3A Homo sapiens P57075
Y2H
21516116
种属内
SPRY2 O43597 LONRF1 Homo sapiens Q17RB8
Validated Y2H
25416956
种属内
SPRY2 O43597 LONRF1 Homo sapiens Q17RB8
Y2H Array
25416956
种属内
SPRY2 O43597 USP20 Homo sapiens Q9Y2K6
Validated Y2H
25416956
种属内
SPRY2 O43597 USP20 Homo sapiens Q9Y2K6
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 TXNDC5 Homo sapiens Q86UY0
Validated Y2H
25416956
种属内
SPRY2 O43597 TXNDC5 Homo sapiens Q86UY0
Y2H Array
25416956
种属内
SPRY2 O43597 SH3KBP1 Homo sapiens Q96B97
Anti Tag CoIP
15962011
种属内
SPRY2 O43597 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
种属内
SPRY2 O43597 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
种属内
SPRY2 O43597 EIF4E2 Homo sapiens O60573
Validated Y2H
25416956
种属内
SPRY2 O43597 EIF4E2 Homo sapiens O60573
Y2H Array
25416956
种属内
SPRY2 O43597 EIF4E2 Homo sapiens O60573
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 GRB2 Homo sapiens P62993
Filter Binding
16893902
种属内
SPRY2 O43597 GRB2 Homo sapiens P62993
Anti Bait CoIP
16893902
种属内
SPRY2 O43597 GNE Homo sapiens Q9Y223
Validated Y2H
25416956
种属内
SPRY2 O43597 GNE Homo sapiens Q9Y223
Y2H Array
25416956
种属内
SPRY2 O43597 CBL Homo sapiens P22681
Anti Tag CoIP
18273061
种属内
SPRY2 O43597 CBL Homo sapiens P22681
Anti Bait CoIP
16893902
种属内
SPRY2 O43597 CBL Homo sapiens P22681
ITC
18273061
种属内
SPRY2 O43597 CBL Homo sapiens P22681
Anti Tag CoIP
15962011
种属内
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5
Validated Y2H
25416956
种属内
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
25416956
种属内
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5
Anti Tag CoIP
33961781
种属内
SPRY2 O43597 HEXIM2 Homo sapiens Q96MH2
Validated Y2H
25416956
种属内
SPRY2 O43597 HEXIM2 Homo sapiens Q96MH2
Y2H Array
25416956
种属内
SPRY2 O43597 NCK2 Homo sapiens O43639
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 NCK2 Homo sapiens O43639
Y2H Array
25416956
种属内
SPRY2 O43597 MDFI Homo sapiens Q99750
Y2H Array
25416956
种属内
SPRY2 O43597 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Pooling
16189514
种属内
SPRY2 O43597 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
25416956
种属内
SPRY2 O43597 GRAP2 Homo sapiens O75791
Y2H Array
25416956
种属内
SPRY2 O43597 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 OTX1 Homo sapiens P32242
Y2H
21516116
种属内
SPRY2 O43597 OTX1 Homo sapiens P32242
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 OTX1 Homo sapiens P32242
Validated Y2H
25416956
种属内
SPRY2 O43597 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 AQP1 Homo sapiens P29972
Y2H Array
25416956
种属内
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1
Validated Y2H
25416956
种属内
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
种属内
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
种属内
SPRY2 O43597 STK16 Homo sapiens O75716
Validated Y2H
25416956
种属内
SPRY2 O43597 STK16 Homo sapiens O75716
Y2H Array
25416956
种属内
SPRY2 O43597 TCAF1 Homo sapiens Q9Y4C2
Y2H Array
25416956
种属内
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6
Y2H Array
25416956
种属内
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6
Validated Y2H
25416956
种属内
SPRY2 O43597 MAPKBP1 Homo sapiens O60336
Y2H Array
25416956
种属内
SPRY2 O43597 MAPKBP1 Homo sapiens O60336
Y2H Prey Pooling
25416956
种属内
SPRY2 O43597 CHRD Homo sapiens Q9H2X0
Y2H Array
25416956
种属内
SPRY2 O43597 CHRD Homo sapiens Q9H2X0
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

SPRY2 抗体

目录号 产品名 应用 反应物种
HY-P81859 Sprouty 2 Antibody (YA1604) WB, IHC-P, ICC/IF, IP Human, Rat

关联疾病

疾病名称 别名
Iga Nephropathy 3

Iga Nephropathy, Susceptibility To, 3

IGAN3

{Iga Nephropathy, Susceptibility To, 3}

Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Focal Segmental Glomerulosclerosis 3

FSGS3

Focal Segmental Glomerulosclerosis 3, Susceptibility To

Glomerulosclerosis, Focal Segmental, 3

Glomerulosclerosis, Focal Segmental, 3, Susceptibility To

Glomerulosclerosis, Segmental, Focal, Type 3, Susceptibility To

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome

Nfls

LGSS

Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome

Achondroplasia

Achondroplastic Dwarfism

ACH

Osteosclerosis Congenita

Achondroplastic Physique

Chondrodystrophia

Dwarf, Achondroplastic

Achondroplastic Short Stature

Congenital Osteosclerosis

Lacrimoauriculodentodigital Syndrome

Ladd Syndrome

Levy-Hollister Syndrome

Lacrimo-Auriculo-Dento-Digital Syndrome

LADD

Lacrimoauriculodento-Digital Syndrome

Levy Hollister Syndrome

Lard Syndrome

Lacrimoauriculoradiodental Syndrome

LADDS

Congenital Duodenal Obstruction Due To Malrotation Of Intestine

Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis

Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate

Van Der Woude Syndrome

Lip-Pit Syndrome

Vws

Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip

Vdws

Lps

Lip Pit Syndrome

Cleft Lip/Palate With Mucous Cysts Of Lower Lip

Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments

Orofacial Cleft

Cleft, Orofacial

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus SPRY2 VGNC VGNC:35242
Mus musculus SPRY2 MGD MGI:1345138
Felis catus SPRY2 VGNC VGNC:65650
Rattus norvegicus SPRY2 RGD RGD:1311472
Macaca mulatta SPRY2 VGNC VGNC:106300
Canis familiaris SPRY2 VGNC VGNC:46766