USP20 - ubiquitin specific peptidase 20 Gene

中文名称：泛素特异性肽酶 20

种属: Homo sapiens

同用名: VDU2; hVDU2; LSFR3A

关于 USP20

功能概要

该基因编码一种泛素特异性加工蛋白酶，该蛋白酶最初被鉴定为 VHL (冯希佩尔-林道病) 蛋白 E3 泛素连接酶复合物的底物。除了被 VHL-E3 连接酶复合物泛素化外，这种酶去泛素化缺氧诱导因子 (HIF) -1 α，从而导致 HIF-1alpha 靶向基因的表达增加，这些基因在血管生成、葡萄糖代谢、细胞增殖和转移。由该基因编码的酶还通过介导 β2 肾上腺素能受体 (ADRB2) 的去泛素化来调节 G 蛋白偶联受体信号。这种酶是一种普遍表达的硫酯水解酶。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2013 年 1 月]

This gene encodes a ubiquitin specific processing Protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin Ligase complex. In addition to being ubiquitinated by the VHL-E3 Ligase complex, this Enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The Enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 Adrenergic Receptor (ADRB2). This Enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]