1. Gene
  2. ITGB3BP - integrin subunit beta 3 binding protein Gene

ITGB3BP - integrin subunit beta 3 binding protein Gene

中文名称:整合素亚基β3 结合蛋白

种属: Homo sapiens

同用名: CENPR; NRIF3; TAP20; CENP-R; HSU37139

基因 ID: 23421 | 基因类型: protein coding

关于 ITGB3BP

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:63,440,770-63,529,187 (from NCBI)

This gene has 14 transcripts (splice variants) and 120 orthologues. Ubiquitous expression in testis (RPKM 5.3), adrenal (RPKM 3.4) and 25 other tissues.

功能概要

该基因编码一个转录辅助调节因子,该调节因子结合并增强核受体家族、甲状腺激素受体和类视黄醇 X 受体成员的活性。这种蛋白质还充当 NF-kappaB 依赖性信号的辅阻遏物。该蛋白通过 Caspase 2 介导的信号通路诱导乳腺癌细胞凋亡。这种蛋白质也是着丝粒特异性组蛋白 H3 变体核小体相关复合物 (CENP-NAC) 的组成部分,并且可能通过将组蛋白 H3 变体 CENP-A 募集到着丝粒参与有丝分裂进程。交替剪接导致多个转录本变体。[RefSeq 提供,2011 年 9 月]

This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces Apoptosis in breast Cancer cells through a Caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

ITGB3BP 基因产物(5)

mRNA Protein Name
NM_001206739.2 NP_001193668.1 centromere protein R isoform 1
NM_001347145.2 NP_001334074.1 centromere protein R isoform 3
NM_001347147.2 NP_001334076.1 centromere protein R isoform 4
NM_001347148.2 NP_001334077.1 centromere protein R isoform 5
NM_014288.5 NP_055103.3 centromere protein R isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of inner kinetochore IPI
IPI: 通过物理相互作用推断
36085283 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ITGB3BP 蛋白结构

CENP-R

CENP-R: Kinetochore component, CENP-R (25 - 161)

  • 0
  • 100
  • 177 a.a.
蛋白主名 其他名称

centromere protein R

beta 3 endonexin

ITGB3BP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ITGB3BP Q13352 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
种属内
ITGB3BP Q13352 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
种属内
ITGB3BP Q13352 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
种属内
ITGB3BP Q13352 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
31515488
种属内
ITGB3BP Q13352 NRDE2 Homo sapiens Q9H7Z3
Validated Y2H
32296183
种属内
ITGB3BP Q13352 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
种属内
ITGB3BP Q13352 KIAA0930 Homo sapiens Q6ICG6-3
Validated Y2H
32296183
种属内
ITGB3BP Q13352 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
种属内
ITGB3BP Q13352 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
种属内
ITGB3BP Q13352 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
种属内
ITGB3BP Q13352 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
ITGB3BP Q13352 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
ITGB3BP Q13352 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
ITGB3BP Q13352 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
种属内
ITGB3BP Q13352 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
种属内
ITGB3BP Q13352 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
种属内
ITGB3BP Q13352 CENPU Homo sapiens Q71F23
Anti Tag CoIP
33961781
种属内
ITGB3BP Q13352 CENPU Homo sapiens Q71F23
Anti Tag CoIP
26496610
种属内
ITGB3BP Q13352 NUP58 Homo sapiens Q9BVL2
Y2H Pooling
32814053
种属内
ITGB3BP Q13352 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
ITGB3BP Q13352 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
ITGB3BP Q13352 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
ITGB3BP Q13352 HRAS Homo sapiens P01112
Y2H Pooling
32814053
种属内
ITGB3BP Q13352 HRAS Homo sapiens P01112
Validated Y2H
32814053
种属内
ITGB3BP Q13352 HRAS Homo sapiens P01112
Y2H Array
32814053
种属内
ITGB3BP Q13352 GRB2 Homo sapiens P62993
Y2H Array
32814053
种属内
ITGB3BP Q13352 GRB2 Homo sapiens P62993
Y2H Pooling
32814053
种属内
ITGB3BP Q13352 GRB2 Homo sapiens P62993
Validated Y2H
32814053
种属内
ITGB3BP Q13352 LSAMP Homo sapiens Q13449
Y2H Pooling
32814053
种属内
ITGB3BP Q13352 LSAMP Homo sapiens Q13449
Validated Y2H
32814053
种属内
ITGB3BP Q13352 LSAMP Homo sapiens Q13449
Y2H Array
32814053
种属内
ITGB3BP Q13352 ARFIP2 Homo sapiens P53365
Y2H Prey Pooling
25416956
种属内
ITGB3BP Q13352 ARFIP2 Homo sapiens P53365
Y2H Pooling
16189514
种属内
ITGB3BP Q13352 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属内
ITGB3BP Q13352 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
ITGB3BP Q13352 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
种属内
ITGB3BP Q13352 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
种属内
ITGB3BP Q13352 CERT1 Homo sapiens Q9Y5P4
Y2H Prey Pooling
25416956
种属内
ITGB3BP Q13352 CERT1 Homo sapiens Q9Y5P4
Y2H Pooling
16189514
种属内
ITGB3BP Q13352 CERT1 Homo sapiens Q9Y5P4
Validated Y2H
25416956
种属内
ITGB3BP Q13352 CERT1 Homo sapiens Q9Y5P4
Y2H Array
25416956
种属内
ITGB3BP Q13352 GTPBP3 Homo sapiens Q969Y2
Validated Y2H
32296183
种属内
ITGB3BP Q13352 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
ITGB3BP Q13352 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
种属内
ITGB3BP Q13352 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
32296183
种属内
ITGB3BP Q13352 PIK3R3 Homo sapiens Q92569
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus ITGB3BP VGNC VGNC:67851
Mus musculus ITGB3BP MGD MGI:1914983
Canis familiaris ITGB3BP VGNC VGNC:53418
Rattus norvegicus ITGB3BP RGD RGD:1310044
Macaca mulatta ITGB3BP VGNC VGNC:73787
Bos taurus ITGB3BP VGNC VGNC:30328