1. Gene
  2. PIK3R3 - phosphoinositide-3-kinase regulatory subunit 3 Gene

PIK3R3 - phosphoinositide-3-kinase regulatory subunit 3 Gene

中文名称:磷酸肌醇 3 激酶调节亚基 3

种属: Homo sapiens

同用名: p55; p55PIK; p55-GAMMA

基因 ID: 8503 | 基因类型: protein coding

关于 PIK3R3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:46,040,140-46,174,901 (from NCBI)

This gene has 7 transcripts (splice variants), 277 orthologues and 2 paralogues. Broad expression in testis (RPKM 19.6), fat (RPKM 8.4) and 20 other tissues.

功能概要

磷脂酰肌醇 3-激酶 (PI3K) 磷酸化磷脂酰肌醇和类似化合物,然后充当生长信号通路中的第二信使。 PI3K 由催化亚基和调节亚基组成。该基因编码的蛋白质代表 PI3K 的一个调节亚基。编码的蛋白质包含两个 SH2 结构域,通过它们结合活化的蛋白酪氨酸激酶以调节其活性。[RefSeq 提供,2016 年 6 月]

Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated Protein Tyrosine Kinases to regulate their activity. [provided by RefSeq, Jun 2016]

PIK3R3 基因产物(11)

mRNA Protein Name
NM_001114172.1 NP_001107644.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1
NM_001303428.1 NP_001290357.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3
NM_001303429.2 NP_001290358.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4
NM_001328648.1 NP_001315577.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328649.1 NP_001315578.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328650.1 NP_001315579.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328651.1 NP_001315580.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328652.2 NP_001315581.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6
NM_001328653.2 NP_001315582.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7
NM_001328654.2 NP_001315583.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 8
NM_003629.4 NP_003620.3 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
20624904 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16273093 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration involved in sprouting angiogenesis IGI
IGI: 通过遗传相互作用推断
28341552 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
28341552 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
28341552 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
28341552 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PIK3R3 蛋白结构

SH2

SH2: SH2 domain (65 - 140)

SH2

SH2: SH2 domain (358 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
蛋白主名 其他名称

phosphatidylinositol 3-kinase regulatory subunit gamma

PI3-kinase regulatory subunit gamma

PIK3R3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PIK3R3 Q92569 PTK2 Homo sapiens I6L996 32296183
种属内
PIK3R3 Q92569 PTK2 Homo sapiens I6L996 32296183
种属内
PIK3R3 Q92569 CCDC196 Homo sapiens A0A1B0GWI1 32296183
种属内
PIK3R3 Q92569 CCDC196 Homo sapiens A0A1B0GWI1 32296183
种属内
PIK3R3 Q92569 SPMIP6 Homo sapiens Q8NCR6 32296183
种属内
PIK3R3 Q92569 SPMIP6 Homo sapiens Q8NCR6 32296183
种属内
PIK3R3 Q92569 PBX4 Homo sapiens Q9BYU1 32296183
种属内
PIK3R3 Q92569 PBX4 Homo sapiens Q9BYU1 32296183
种属内
PIK3R3 Q92569 PBX4 Homo sapiens Q9BYU1 32296183
种属内
PIK3R3 Q92569 PLAAT4 Homo sapiens Q9UL19 32296183
种属内
PIK3R3 Q92569 PLAAT4 Homo sapiens Q9UL19 32296183
种属内
PIK3R3 Q92569 PLAAT4 Homo sapiens Q9UL19 32296183
种属内
PIK3R3 Q92569 MET Homo sapiens P08581
FPS
24728074
种属内
PIK3R3 Q92569 PARD6A Homo sapiens Q9NPB6-2 25814554
种属内
PIK3R3 Q92569 STAT5B Homo sapiens P51692 32296183
种属内
PIK3R3 Q92569 STAT5B Homo sapiens P51692 32296183
种属内
PIK3R3 Q92569 ARID4B Homo sapiens Q4LE39-3 32296183
种属内
PIK3R3 Q92569 ARID4B Homo sapiens Q4LE39-3 32296183
种属内
PIK3R3 Q92569 L3MBTL3 Homo sapiens Q96JM7-2 32296183
种属内
PIK3R3 Q92569 L3MBTL3 Homo sapiens Q96JM7-2 32296183
种属内
PIK3R3 Q92569 L3MBTL3 Homo sapiens Q96JM7-2 32296183
种属内
PIK3R3 Q92569 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
PIK3R3 Q92569 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
PIK3R3 Q92569 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
PIK3R3 Q92569 CIMIP2B Homo sapiens A8MTA8-2 32296183
种属内
PIK3R3 Q92569 CIMIP2B Homo sapiens A8MTA8-2 32296183
种属内
PIK3R3 Q92569 CHRDL2 Homo sapiens Q6WN34-2 32296183
种属内
PIK3R3 Q92569 CHRDL2 Homo sapiens Q6WN34-2 32296183
种属内
PIK3R3 Q92569 CCDC89 Homo sapiens Q8N998 32296183
种属内
PIK3R3 Q92569 CCDC89 Homo sapiens Q8N998 32296183
种属内
PIK3R3 Q92569 SPATA32 Homo sapiens Q96LK8 32296183
种属内
PIK3R3 Q92569 SPATA32 Homo sapiens Q96LK8 32296183
种属内
PIK3R3 Q92569 SPATA32 Homo sapiens Q96LK8 32296183
种属内
PIK3R3 Q92569 FNDC8 Homo sapiens Q8TC99 32296183
种属内
PIK3R3 Q92569 FNDC8 Homo sapiens Q8TC99 32296183
种属内
PIK3R3 Q92569 KIT Homo sapiens P10721
FPS
24728074
种属内
PIK3R3 Q92569 WDFY3 Homo sapiens Q8IZQ1 25814554
种属内
PIK3R3 Q92569 WDFY3 Homo sapiens Q8IZQ1 25814554
种属内
PIK3R3 Q92569 C3orf36 Homo sapiens Q3SXR2 32296183
种属内
PIK3R3 Q92569 C3orf36 Homo sapiens Q3SXR2 32296183
种属内
PIK3R3 Q92569 SPSB2 Homo sapiens Q99619 25814554
种属内
PIK3R3 Q92569 SPSB2 Homo sapiens Q99619 25814554
种属内
PIK3R3 Q92569 LAP3 Homo sapiens P28838 32296183
种属内
PIK3R3 Q92569 LAP3 Homo sapiens P28838 32296183
种属内
PIK3R3 Q92569 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
PIK3R3 Q92569 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
PIK3R3 Q92569 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
PIK3R3 Q92569 PIK3CB Homo sapiens P42338 28514442
种属内
PIK3R3 Q92569 PIK3CB Homo sapiens P42338 33961781
种属内
PIK3R3 Q92569 PIK3CB Homo sapiens P42338 22402981
种属内
PIK3R3 Q92569 PLEKHS1 Homo sapiens Q5SXH7-1 25814554
种属内
PIK3R3 Q92569 PRKAR1B Homo sapiens P31321 32296183
种属内
PIK3R3 Q92569 PRKAR1B Homo sapiens P31321 32296183
种属内
PIK3R3 Q92569 SERTAD2 Homo sapiens Q14140 32296183
种属内
PIK3R3 Q92569 SERTAD2 Homo sapiens Q14140 32296183
种属内
PIK3R3 Q92569 RBP7 Homo sapiens Q96R05 25814554
种属内
PIK3R3 Q92569 RBP7 Homo sapiens Q96R05 25814554
种属内
PIK3R3 Q92569 NEBL Homo sapiens O76041 32296183
种属内
PIK3R3 Q92569 NEBL Homo sapiens O76041 32296183
种属内
PIK3R3 Q92569 EGFR Homo sapiens P00533
PLA
25241761
种属内
PIK3R3 Q92569 EGFR Homo sapiens P00533 16273093
种属内
PIK3R3 Q92569 ZBTB18 Homo sapiens Q99592 32296183
种属内
PIK3R3 Q92569 ZBTB18 Homo sapiens Q99592 32296183
种属内
PIK3R3 Q92569 ZBTB18 Homo sapiens Q99592 32296183
种属内
PIK3R3 Q92569 OLIG1 Homo sapiens Q8TAK6 25814554
种属内
PIK3R3 Q92569 OLIG1 Homo sapiens Q8TAK6 25814554
种属内
PIK3R3 Q92569 SOCS4 Homo sapiens Q8WXH5 25814554
种属内
PIK3R3 Q92569 ZNF620 Homo sapiens Q6ZNG0 32296183
种属内
PIK3R3 Q92569 ZNF620 Homo sapiens Q6ZNG0 32296183
种属内
PIK3R3 Q92569 PELI3 Homo sapiens Q8N2H9 25814554
种属内
PIK3R3 Q92569 PELI3 Homo sapiens Q8N2H9 25814554
种属内
PIK3R3 Q92569 PELI3 Homo sapiens Q8N2H9 25814554
种属内
PIK3R3 Q92569 HTT Homo sapiens P42858
Y2H
17500595
种属内
PIK3R3 Q92569 SH2D2A Homo sapiens Q9NP31 25814554
种属内
PIK3R3 Q92569 IRS1 Homo sapiens P35568 25814554
种属内
PIK3R3 Q92569 IRS1 Homo sapiens P35568 25814554
种属内
PIK3R3 Q92569 GAB1 Homo sapiens Q13480
FPS
24728074
种属内
PIK3R3 Q92569 CBL Homo sapiens P22681 25814554
种属内
PIK3R3 Q92569 CBL Homo sapiens P22681 25814554
种属内
PIK3R3 Q92569 OTUD7B Homo sapiens Q6GQQ9 25814554
种属内
PIK3R3 Q92569 OTUD7B Homo sapiens Q6GQQ9 25814554
种属内
PIK3R3 Q92569 OTUD7B Homo sapiens Q6GQQ9 25814554
种属内
PIK3R3 Q92569 ARL6IP4 Homo sapiens Q66PJ3-4 25814554
种属内
PIK3R3 Q92569 ARL6IP4 Homo sapiens Q66PJ3-4 25814554
种属内
PIK3R3 Q92569 AR Homo sapiens P10275
FPS
24728074
种属内
PIK3R3 Q92569 SRC Homo sapiens P12931 25814554
种属内
PIK3R3 Q92569 RUSC1 Homo sapiens Q9BVN2 32296183
种属内
PIK3R3 Q92569 RUSC1 Homo sapiens Q9BVN2 32296183
种属内
PIK3R3 Q92569 RUSC1 Homo sapiens Q9BVN2 32296183
种属内
PIK3R3 Q92569 ERBB2 Homo sapiens P04626 16273093
种属内
PIK3R3 Q92569 PTK2 Homo sapiens Q05397 25814554
种属内
PIK3R3 Q92569 PTK2 Homo sapiens Q05397 25814554
种属内
PIK3R3 Q92569 ITGB3BP Homo sapiens Q13352 32296183
种属内
PIK3R3 Q92569 ITGB3BP Homo sapiens Q13352 32296183
种属内
PIK3R3 Q92569 DRAP1 Homo sapiens Q14919 32296183
种属内
PIK3R3 Q92569 DRAP1 Homo sapiens Q14919 32296183
种属内
PIK3R3 Q92569 ANTKMT Homo sapiens Q9BQD7 32296183
种属内
PIK3R3 Q92569 ANTKMT Homo sapiens Q9BQD7 32296183
种属内
PIK3R3 Q92569 ANTKMT Homo sapiens Q9BQD7 32296183
种属内
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 32296183
种属内
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 33961781
种属内
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 32296183
种属内
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 28514442
种属内
PIK3R3 Q92569 ERBB3 Homo sapiens P21860 16273093
种属内
PIK3R3 Q92569 FRS3 Homo sapiens O43559 25814554
种属内
PIK3R3 Q92569 FRS3 Homo sapiens O43559 25814554
种属内
PIK3R3 Q92569 KIAA0408 Homo sapiens Q6ZU52 32296183
种属内
PIK3R3 Q92569 KIAA0408 Homo sapiens Q6ZU52 32296183
种属内
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 25814554
种属内
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 32296183
种属内
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 32296183
种属内
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 32296183
种属内
PIK3R3 Q92569 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属内
PIK3R3 Q92569 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属内
PIK3R3 Q92569 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属内
PIK3R3 Q92569 ENKD1 Homo sapiens Q9H0I2 32296183
种属内
PIK3R3 Q92569 ENKD1 Homo sapiens Q9H0I2 32296183
种属内
PIK3R3 Q92569 ENKD1 Homo sapiens Q9H0I2 32296183
种属内
PIK3R3 Q92569 SSBP4 Homo sapiens Q9BWG4 32296183
种属内
PIK3R3 Q92569 SSBP4 Homo sapiens Q9BWG4 32296183
种属内
PIK3R3 Q92569 SSBP4 Homo sapiens Q9BWG4 32296183
种属内
PIK3R3 Q92569 TASOR2 Homo sapiens Q5VWN6 32296183
种属内
PIK3R3 Q92569 TASOR2 Homo sapiens Q5VWN6 32296183
种属内
PIK3R3 Q92569 TNNI1 Homo sapiens P19237 32296183
种属内
PIK3R3 Q92569 TNNI1 Homo sapiens P19237 32296183
种属内
PIK3R3 Q92569 CRYBA2 Homo sapiens P53672 25814554
种属内
PIK3R3 Q92569 CRYBA2 Homo sapiens P53672 25814554
种属内
PIK3R3 Q92569 METTL27 Homo sapiens Q8N6F8 25814554
种属内
PIK3R3 Q92569 NAB2 Homo sapiens Q15742 32296183
种属内
PIK3R3 Q92569 NAB2 Homo sapiens Q15742 32296183
种属内
PIK3R3 Q92569 HCK Homo sapiens P08631-2 25814554
种属间: 跨种属相互作用 种属内: 同种属相互作用

PIK3R3 抗体

目录号 产品名 应用 反应物种
HY-P80866 PI3 Kinase p55 gamma Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Asbestos-Related Lung Carcinoma
Cervical Non-Keratinizing Squamous Cell Carcinoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PIK3R3 RGD RGD:621042
Mus musculus PIK3R3 MGD MGI:109277
Others PIK3R3 NCBI