1. Gene
  2. SOCS4 - suppressor of cytokine signaling 4 Gene

SOCS4 - suppressor of cytokine signaling 4 Gene

中文名称:细胞因子信号传导抑制因子 4

种属: Homo sapiens

同用名: SOCS7

基因 ID: 122809 | 基因类型: protein coding

关于 SOCS4

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,027,236-55,049,489 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues and 7 paralogues. Ubiquitous expression in appendix (RPKM 5.4), lymph node (RPKM 5.2) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个 SH2 结构域和一个 SOCS BOX 结构域。因此,该蛋白质属于细胞因子信号转导抑制因子 (SOCS) ,也称为 STAT 诱导的 STAT 抑制剂 (SSI) 蛋白质家族。已知 SOCS 家族成员是细胞因子信号转导的细胞因子诱导型负调节剂。已经为该基因发现了编码相同蛋白质的两个选择性剪接的转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT Inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SOCS4 基因产物(2)

mRNA Protein Name
NM_080867.3 NP_543143.1 suppressor of cytokine signaling 4
NM_199421.2 NP_955453.1 suppressor of cytokine signaling 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25814554 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of epidermal growth factor-activated receptor activity IDA
IDA: 通过直接分析推断
15590694 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

suppressor of cytokine signaling 4

SH2 domain containing SOCS box protein

SOCS4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SOCS4 Q8WXH5 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra SOCS4 Q8WXH5 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra SOCS4 Q8WXH5 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 BSCL2 Homo sapiens J3KQ12
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 BSCL2 Homo sapiens J3KQ12
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 BSCL2 Homo sapiens J3KQ12
Y2H Array
32814053
Intra SOCS4 Q8WXH5 SPTLC1 Homo sapiens O15269-2
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 SPTLC1 Homo sapiens O15269-2
Y2H Array
32814053
Intra SOCS4 Q8WXH5 SPTLC1 Homo sapiens O15269-2
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 PANK2 Homo sapiens Q9BZ23-2
Y2H Array
32814053
Intra SOCS4 Q8WXH5 PANK2 Homo sapiens Q9BZ23-2
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 PANK2 Homo sapiens Q9BZ23-2
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 PINK1 Homo sapiens Q9BXM7
Lumier
25814554
Intra SOCS4 Q8WXH5 PINK1 Homo sapiens Q9BXM7
Validated Y2H
25814554
Intra SOCS4 Q8WXH5 RBP7 Homo sapiens Q96R05
Y2H Array
25814554
Intra SOCS4 Q8WXH5 RBP7 Homo sapiens Q96R05
Lumier
25814554
Intra SOCS4 Q8WXH5 GRB2 Homo sapiens P62993
Validated Y2H
25814554
Intra SOCS4 Q8WXH5 GRB2 Homo sapiens P62993
Lumier
25814554
Intra SOCS4 Q8WXH5 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra SOCS4 Q8WXH5 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra SOCS4 Q8WXH5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 GARS1 Homo sapiens P41250
Y2H Array
32814053
Intra SOCS4 Q8WXH5 GARS1 Homo sapiens P41250
Y2H Pooling
32814053
Intra SOCS4 Q8WXH5 GARS1 Homo sapiens P41250
Validated Y2H
32814053
Intra SOCS4 Q8WXH5 FRS3 Homo sapiens O43559
Y2H Array
25814554
Intra SOCS4 Q8WXH5 PIK3R3 Homo sapiens Q92569
Validated Y2H
25814554
Intra SOCS4 Q8WXH5 PIK3R3 Homo sapiens Q92569
Y2H Array
25814554
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Borderline Glaucoma

Preglaucoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SOCS4 RGD RGD:1306503
Bos taurus SOCS4 VGNC VGNC:35122
Macaca mulatta SOCS4 VGNC VGNC:77741
Felis catus SOCS4 VGNC VGNC:80837
Mus musculus SOCS4 MGD MGI:1914546
Canis familiaris SOCS4 VGNC VGNC:46651