2. Gene
  3. PLAAT4 - phospholipase A and acyltransferase 4 Gene

PLAAT4 - phospholipase A and acyltransferase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：磷脂酶 A 和酰基转移酶 4

种属: Homo sapiens

同用名: RIG1; TIG3; HRSL4; HRASLS4; PLAAT-4; RARRES3; PLA1/2-3

基因 ID: 5920 | 基因类型: protein coding

关于 PLAAT4

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:63,536,808-63,546,458 (from NCBI)

This gene has 5 transcripts (splice variants), 73 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 43.2), duodenum (RPKM 36.6) and 24 other tissues.

功能概要

类视黄醇发挥生物学作用，例如有效的生长抑制和细胞分化活性，并用于治疗过度增殖性皮肤病。这些作用是由特定的核受体蛋白介导的，这些核受体蛋白是转录调节因子的类固醇和甲状腺激素受体超家族的成员。 RARRES1、RARRES2 和 RARRES3 是其表达被合成类视黄醇他扎罗汀上调的基因。 RARRES3 被认为充当肿瘤抑制剂或生长调节剂。[RefSeq 提供，2008 年 7 月]

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear Receptor Proteins that are members of the steroid and Thyroid Hormone Receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

PLAAT4 基因产物(1)

mRNA Protein Name
NM_004585.5 NP_004576.2 phospholipase A and acyltransferase 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acyltransferase activity IDA
IDA: 通过直接分析推断
22825852 GOA
enables phospholipase A1 activity IDA
IDA: 通过直接分析推断
22825852 GOA
enables phospholipase A2 activity IDA
IDA: 通过直接分析推断
20100577 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17762858 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: 通过直接分析推断
22825852 GOA
involved in phospholipid metabolic process IDA
IDA: 通过直接分析推断
20100577 GOA
involved in positive regulation of keratinocyte differentiation IMP
IMP: 通过突变表型推断
17762858 GOA
involved in positive regulation of protein-glutamine gamma-glutamyltransferase activity IMP
IMP: 通过突变表型推断
17762858 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
17762858 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLAAT4 蛋白结构

LRAT

LRAT: Lecithin retinol acyltransferase (5 - 125)

  • 0
  • 100
  • 164 a.a.
蛋白主名 其他名称

phospholipase A and acyltransferase 4

HRAS-like suppressor 4

PLAAT4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLAAT4 Q9UL19 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
种属内
PLAAT4 Q9UL19 SGTA Homo sapiens O43765
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix
Poland Syndrome

Poland Anomaly

Poland Sequence

Poland Syndactyly

Poland'S Syndrome

Poland'S Anomaly

Poland'S Syndactyly

Acro-Pectoro-Renal Field Defect

Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys

Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand

Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand
Psoriasis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10639 PLAAT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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