OLIG1 - oligodendrocyte transcription factor 1 Gene

中文名称：少突胶质细胞转录因子 1

种属: Homo sapiens

同用名: BHLHB6; BHLHE21

基因 ID: 116448 | 基因类型: protein coding

关于 OLIG1

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,070,141-33,072,413 (from NCBI)

This gene has 3 transcripts (splice variants), 157 orthologues and 15 paralogues.

功能概要

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计通过 RNA 聚合酶 II 参与神经元分化和转录调节。预计在神经元命运承诺的上游或内部行动。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuron fate commitment. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OLIG1 基因产物(1)

mRNA	Protein	Name
NM_138983.3	NP_620450.2	oligodendrocyte transcription factor 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18923419	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OLIG1 蛋白结构

HLH

0
100
200
271 a.a.

蛋白主名

其他名称

oligodendrocyte transcription factor 1

basic domain, helix-loop-helix protein, class B, 6

OLIG1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	OLIG1	Q8TAK6	SH2D1B	Homo sapiens	O14796	Y2H Array	25814554
种属内	OLIG1	Q8TAK6	YES1	Homo sapiens	P07947	Validated Y2H	25814554
种属内	OLIG1	Q8TAK6	YES1	Homo sapiens	P07947	Y2H Array	25814554
种属内	OLIG1	Q8TAK6	GRB7	Homo sapiens	Q14451	Validated Y2H	25814554
种属内	OLIG1	Q8TAK6	GRB7	Homo sapiens	Q14451	Y2H Array	25814554
种属内	OLIG1	Q8TAK6	HCK	Homo sapiens	P08631-2	Y2H Array	25814554

种属间: 跨种属相互作用 种属内: 同种属相互作用

OLIG1 抗体

目录号	产品名	应用	反应物种
HY-P82981	Olig1 Antibody (YA2726)	WB, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Anaplastic Oligodendroglioma

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Periventricular Leukomalacia

Leukomalacia, Periventricular	Pvl
Leukomalacia Periventricular

Encephalomalacia

Pelizaeus-Merzbacher Disease

PMD	HLD1
Pelizaeus-Merzbacher Brain Sclerosis	Leukodystrophy, Hypomyelinating, 1
Diffuse Familial Brain Sclerosis	Pelizaeus Merzbacher Brain Sclerosis
Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type	Cockayne-Pelizaeus-Merzbacher Disease
Hypomyelinating Leukodystrophy 1	Leukodystrophy, Sudanophilic
Pelizaeus Merzbacher Disease	Hypomyelinating Leukodystrophy, 1
Sudanophilic Leukodystrophy	Pelizaeus-Merzbacher Disease, Connatal Form
Connatal Pmd	Pelizaeus-Merzbacher Disease Type Ii
Severe Pmd	Null Syndrome
Plp1 Null Syndrome	Pelizaeus-Merzbacher Disease, Null Syndrome
Brain Sclerosis Diffuse Familial	Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type
Leukodystrophy Hypomyelinating 1	Diffuse Cerebral Sclerosis Of Schilder

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09777	OLIG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	OLIG1	VGNC	VGNC:53034
Bos taurus	OLIG1	VGNC	VGNC:32425
Mus musculus	OLIG1	MGD	MGI:1355334
Rattus norvegicus	OLIG1	RGD	RGD:621129
Macaca mulatta	OLIG1	VGNC	VGNC:75413
Felis catus	OLIG1	VGNC	VGNC:102791

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

OLIG1 - oligodendrocyte transcription factor 1 Gene

关于 OLIG1

功能概要

OLIG1 基因产物(1)

OLIG1 蛋白结构

OLIG1 蛋白互作信息

OLIG1 抗体

关联疾病

直系同源

热门区域

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OLIG1 - oligodendrocyte transcription factor 1 Gene

关于 OLIG1

功能概要

OLIG1 基因产物(1)

OLIG1 蛋白结构

OLIG1 蛋白互作信息

OLIG1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z