GRB7 - growth factor receptor bound protein 7 Gene

中文名称：生长因子受体结合蛋白 7

种属: Homo sapiens

基因 ID: 2886 | 基因类型: protein coding

关于 GRB7

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,737,938-39,747,285 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues.

功能概要

该基因的产物属于已知与许多受体酪氨酸激酶和信号分子相互作用的一小部分衔接蛋白。该基因编码一种与表皮生长因子受体 (EGFR) 和肝配蛋白受体相互作用的生长因子受体结合蛋白。该蛋白通过与粘着斑激酶 (FAK) 结合，在整合素信号通路和细胞迁移中发挥作用。已发现该基因编码两种不同亚型的几种转录变体。[RefSeq 提供，2011 年 6 月]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of Receptor Tyrosine Kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the Integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GRB7 基因产物(5)

mRNA	Protein	Name
NM_001030002.3	NP_001025173.1	growth factor receptor-bound protein 7 isoform a
NM_001242442.2	NP_001229371.2	growth factor receptor-bound protein 7 isoform b
NM_001242443.2	NP_001229372.1	growth factor receptor-bound protein 7 isoform a
NM_001330207.2	NP_001317136.1	growth factor receptor-bound protein 7 isoform c
NM_005310.5	NP_005301.2	growth factor receptor-bound protein 7 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	15841400	GOA
enables phosphatidylinositol binding	IDA IDA: 通过直接分析推断	12021278	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8940081	GOA
enables protein kinase binding	IDA IDA: 通过直接分析推断	12021278	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	10893408	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	10893408	GOA
located in focal adhesion	IDA IDA: 通过直接分析推断	10893408	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRB7 蛋白结构

BPS

SH2

0
100
200
300
400
500
532 a.a.

蛋白主名

其他名称

growth factor receptor-bound protein 7

B47

GRB7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GRB7	Q14451	LAX1	Homo sapiens	Q8IWV1	Validated Y2H	25416956
种属内	GRB7	Q14451	LAX1	Homo sapiens	Q8IWV1	Y2H Prey Pooling	25416956
种属内	GRB7	Q14451	KIT	Homo sapiens	P10721	FPS	24728074
种属内	GRB7	Q14451	TRIM36	Homo sapiens	Q9NQ86	Validated Y2H	25416956
种属内	GRB7	Q14451	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	25416956
种属内	GRB7	Q14451	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	25416956
种属内	GRB7	Q14451	HAX1	Homo sapiens	O00165	Anti Bait CoIP	20665473
种属内	GRB7	Q14451	OLIG1	Homo sapiens	Q8TAK6	Lumier	25814554
种属内	GRB7	Q14451	RND1	Homo sapiens	Q92730	Y2H	10664463
种属内	GRB7	Q14451	AR	Homo sapiens	P10275	FPS	24728074
种属内	GRB7	Q14451	ERBB2	Homo sapiens	P04626	NMR	12975581
种属内	GRB7	Q14451	ERBB2	Homo sapiens	P04626	Protein Array	16273093
种属内	GRB7	Q14451	PDGFRB	Homo sapiens	P09619	Pull Down	8940081
种属内	GRB7	Q14451	PDGFRB	Homo sapiens	P09619	Competition Binding	8940081
种属内	GRB7	Q14451	LY6G6F	Homo sapiens	Q5SQ64	Anti Tag CoIP	12852788
种属内	GRB7	Q14451	PTK2	Homo sapiens	Q05397	Y2H Array	25814554
种属内	GRB7	Q14451	PTK2	Homo sapiens	Q05397	Lumier	25814554
种属内	GRB7	Q14451	ERBB3	Homo sapiens	P21860	Competition Binding	9516479
种属内	GRB7	Q14451	ERBB3	Homo sapiens	P21860	Protein Array	16273093
种属内	GRB7	Q14451	EPHB1	Homo sapiens	P54762	Y2H	12223469
种属间	GRB7	Q14451	CALM	Bos taurus	P62157	Pull Down	15806159
种属间	GRB7	Q14451	Calm1	Rattus norvegicus	P0DP29	Far-WB	15806159
种属间	GRB7	Q14451	Calm1	Rattus norvegicus	P0DP29	Filter Binding	15806159

种属间: 跨种属相互作用 种属内: 同种属相互作用

GRB7 抗体

目录号	产品名	应用	反应物种
HY-P81420	GRB7 Antibody (YA1165)	IHC-P	Human

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05781	GRB7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GRB7	MGD	MGI:102683
Macaca mulatta	GRB7	VGNC	VGNC:73270
Canis familiaris	GRB7	VGNC	VGNC:41473
Bos taurus	GRB7	VGNC	VGNC:29632
Rattus norvegicus	GRB7	RGD	RGD:619759
Felis catus	GRB7	VGNC	VGNC:67458
Others	GRB7	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GRB7 - growth factor receptor bound protein 7 Gene

关于 GRB7

功能概要

GRB7 基因产物(5)

GRB7 蛋白结构

GRB7 蛋白互作信息

GRB7 抗体

关联疾病

直系同源

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GRB7 - growth factor receptor bound protein 7 Gene

关于 GRB7

功能概要

GRB7 基因产物(5)

GRB7 蛋白结构

GRB7 蛋白互作信息

GRB7 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z