LAX1 - lymphocyte transmembrane adaptor 1 Gene

中文名称：淋巴细胞跨膜接头 1

种属: Homo sapiens

同用名: LAX

基因 ID: 54900 | 基因类型: protein coding

关于 LAX1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,765,183-203,776,372 (from NCBI)

This gene has 3 transcripts (splice variants) and 97 orthologues. Biased expression in lymph node (RPKM 6.4), appendix (RPKM 5.1) and 13 other tissues.

功能概要

启用 SH2 结构域结合活性和蛋白激酶结合活性。参与多个过程，包括 B 细胞激活； MAP 激酶活性的负调节；和 T 细胞活化的负调节。位于高尔基体；胞质溶胶；和质膜。是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAP kinase activity; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAX1 基因产物(3)

mRNA	Protein	Name
NM_001136190.2	NP_001129662.1	lymphocyte transmembrane adapter 1 isoform b
NM_001282878.1	NP_001269807.1	lymphocyte transmembrane adapter 1 isoform c
NM_017773.4	NP_060243.2	lymphocyte transmembrane adapter 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SH2 domain binding	IDA IDA: 通过直接分析推断	12359715	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12359715	GOA
enables protein kinase binding	IDA IDA: 通过直接分析推断	12359715	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in B cell activation	IDA IDA: 通过直接分析推断	12359715	GOA
involved in immune response	IDA IDA: 通过直接分析推断	12359715	GOA
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	12359715	GOA
involved in negative regulation of MAPK cascade	IMP IMP: 通过突变表型推断	12359715	GOA
involved in negative regulation of T cell activation	IDA IDA: 通过直接分析推断	12359715	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	12359715	GOA
NOT located in membrane raft	IDA IDA: 通过直接分析推断	12359715	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

lymphocyte transmembrane adapter 1

LAT-like membrane associated protein

LAX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LAX1	Q8IWV1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Prey Pooling	25416956
种属内	LAX1	Q8IWV1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Array	25416956
种属内	LAX1	Q8IWV1	STAMBPL1	Homo sapiens	Q96FJ0	Validated Y2H	25416956
种属内	LAX1	Q8IWV1	GRB7	Homo sapiens	Q14451	Y2H Array	31515488
种属内	LAX1	Q8IWV1	GRB7	Homo sapiens	Q14451	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Rheumatic Pulmonary Valve Disease

Rheumatic Disease Of Pulmonary Valve

Rheumatic Pulmonary Incompetence

Aortic Valve Insufficiency

Aortic Regurgitation	Rheumatic Aortic Regurgitation
Aortic Insufficiency	Rheumatic Aortic Insufficiency
Rheumatic Aortic Valve Insufficiency	Aortic Incompetence
Corrigan'S Disease	Rheumatic Aortic Valve Regurgitation
Aortic Valve Incompetency	Ai - [Aortic Incompetence]
Incompetent Aortic Valve	Ar - [Aortic Regurgitation]
Calcific Aortic Valve Regurgitation	Myxomatous Aortic Valve Regurgitation
Annular Incompetency Of Aortic Valve	Austin Flint Murmur
Flint Murmur	Rheumatic Aortic Incompetence
Rheumatic Ai - [Aortic Insufficiency]

Mitral Valve Insufficiency

Mitral Regurgitation	Congenital Insufficiency Of Mitral Valve
Congenital Mitral Insufficiency	Congenital Mitral Regurgitation
Mitral Valve Incompetence	Mitral Valve Regurgitation
Mr - [Mitral Regurgitation]	Mi - [Mitral Incompetence]
Mitral Valve Annular Incompetency	Congenital Mitral Valve Incompetence
Congenital Mitral Valve Insufficiency	Congenital Mitral Valve Regurgitation
Congenital Mitral Incompetence

Mitral Valve Disease

Chronic Rheumatic Mitral Valve	Rheumatic Mitral Insufficiency
Disease Of Mitral Valve	Mitral Rh Valve Dis.
Rheumatic Disease Of Mitral Valve	Rheumatic Mitral Valve Changes
Rheumatic Mitral Valve Incompetence	Rheumatic Mitral Valve Regurgitation
Abnormality Of The Mitral Valve	Diseases Of Mitral Valve
Rheumatic Mitral Regurgitation

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07540	LAX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	LAX1	RGD	RGD:1563522
Bos taurus	LAX1	VGNC	VGNC:30802
Mus musculus	LAX1	MGD	MGI:2443362
Felis catus	LAX1	VGNC	VGNC:107891
Macaca mulatta	LAX1	VGNC	VGNC:106401
Canis familiaris	LAX1	VGNC	VGNC:42600

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LAX1 - lymphocyte transmembrane adaptor 1 Gene

关于 LAX1

功能概要

LAX1 基因产物(3)

LAX1 蛋白互作信息

关联疾病

直系同源

热门区域

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LAX1 - lymphocyte transmembrane adaptor 1 Gene

关于 LAX1

功能概要

LAX1 基因产物(3)

LAX1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z