2. Gene
  3. TRIM36 - tripartite motif containing 36 Gene

TRIM36 - tripartite motif containing 36 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 36

种属: Homo sapiens

同用名: ANPH; ANPH1; RNF98; HAPRIN; RBCC728

基因 ID: 55521 | 基因类型: protein coding

关于 TRIM36

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,124,772-115,180,294 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues, 80 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。已针对该基因描述了编码不同蛋白质亚型的多个可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TRIM36 基因产物(5)

mRNA Protein Name
NM_001017397.2 NP_001017397.1 E3 ubiquitin-protein ligase TRIM36 isoform 2
NM_001017398.2 NP_001017398.1 E3 ubiquitin-protein ligase TRIM36 isoform 3
NM_001300752.2 NP_001287681.1 E3 ubiquitin-protein ligase TRIM36 isoform 4
NM_001300759.2 NP_001287688.1 E3 ubiquitin-protein ligase TRIM36 isoform 5
NM_018700.4 NP_061170.2 E3 ubiquitin-protein ligase TRIM36 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic cytokinesis IMP
IMP: 通过突变表型推断
28087737 GOA
involved in regulation of microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
28087737 GOA
involved in spindle organization IMP
IMP: 通过突变表型推断
28087737 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28087737 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM36 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (33 - 61)

zf-B_box

zf-B_box: B-box zinc finger (210 - 248)

fn3

fn3: Fibronectin type III domain (431 - 494)

SPRY

SPRY: SPRY domain (571 - 710)

  • 0
  • 200
  • 400
  • 600
  • 728 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM36

RING finger protein 98

TRIM36 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIM36 Q9NQ86 EIF4A2 Homo sapiens Q14240-2
Validated Y2H
25416956
种属内
TRIM36 Q9NQ86 EIF4A2 Homo sapiens Q14240-2
Y2H Array
25416956
种属内
TRIM36 Q9NQ86 ZMAT2 Homo sapiens Q96NC0
Y2H Prey Pooling
25416956
种属内
TRIM36 Q9NQ86 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
25416956
种属内
TRIM36 Q9NQ86 BTRC Homo sapiens Q9Y297
Y2H Prey Pooling
32296183
种属内
TRIM36 Q9NQ86 BTRC Homo sapiens Q9Y297
Validated Y2H
32296183
种属内
TRIM36 Q9NQ86 BTRC Homo sapiens Q9Y297
Y2H Array
32296183
种属内
TRIM36 Q9NQ86 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
种属内
TRIM36 Q9NQ86 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
种属内
TRIM36 Q9NQ86 GLRX3 Homo sapiens O76003
Y2H Array
32296183
种属内
TRIM36 Q9NQ86 EIF4A2 Homo sapiens Q14240
Y2H Prey Pooling
25416956
种属内
TRIM36 Q9NQ86 ZNF417 Homo sapiens Q8TAU3
Y2H Array
25416956
种属内
TRIM36 Q9NQ86 TRAF3IP3 Homo sapiens Q9Y228
Y2H Prey Pooling
25416956
种属内
TRIM36 Q9NQ86 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
25416956
种属内
TRIM36 Q9NQ86 TRAF3IP3 Homo sapiens Q9Y228
Y2H Array
25416956
种属内
TRIM36 Q9NQ86 GRB7 Homo sapiens Q14451
Y2H Prey Pooling
25416956
种属内
TRIM36 Q9NQ86 GRB7 Homo sapiens Q14451
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Anencephaly 1

ANPH1

Anph

Isolated Anencephaly/Exencephaly

Anencephalus
Anencephaly

Aprosencephaly

Anencephalus

Congenital Absence Of Brain

Absence Of A Large Part Of The Brain And The Skull

Anencephalia

Anencephalic Monster

Brain Absence

Brain Agenesis

Brain Aplasia

Absent Brain

Anencephalic

Congenital Absence Of Cerebrum

Congenital Hemicrania

Incomplete Anencephaly
Non-Syndromic X-Linked Intellectual Disability 101

Mrx101

X-Linked Mental Retardation 101
Syndromic X-Linked Intellectual Disability Cabezas Type

Cabezas Syndrome

Syndromic X-Linked Mental Retardation 15

Mental Retardation, X-Linked, Syndromic 15

Mrss

Mrxs15

Mrxsc

X-Linked Mental Retardation With Short Stature

X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait

Mental Retardation, X-Linked, With Short Stature

Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait
Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D

Hmn Iid

Dhmn2d

Distal Hereditary Motor Neuronopathy Type 2d

Distal Hereditary Motor Neuropathy Type Iid

Neuronopathy, Distal Hereditary Motor, Type 2d

Neuropathy, Distal Hereditary Motor, Type Iid

Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant

Distal Spinal Muscular Atrophy With Calf Predominance

Neuronopathy, Distal Hereditary Motor, 2d

Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant

Dhmn Iid

Neuropathy, Motor, Distal, Hereditary, Type 2d
Gait Apraxia
Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii

Distal Hereditary Motor Neuropathy Type 2

Distal Hereditary Motor Neuropathy Type Ii

Hmn Ii

Hmn2

Distal Hereditary Motor Neuronopathy, Type Ii

Distal Spinal Muscular Atrophy Type 2

Dhmn2

Dsma2

Neuropathy, Motor, Distal, Hereditary, Type Ii

Spinal Muscular Atrophy, Jerash Type
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15040 TRIM36 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TRIM36 MGD MGI:106264
Macaca mulatta TRIM36 VGNC VGNC:79023
Felis catus TRIM36 VGNC VGNC:66536
Canis familiaris TRIM36 VGNC VGNC:47817
Rattus norvegicus TRIM36 RGD RGD:1308714
Bos taurus TRIM36 VGNC VGNC:36331
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