1. Gene
  2. PIK3CB - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Gene

PIK3CB - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Gene

中文名称:磷脂酰肌醇 4,5-二磷酸 3-激酶催化亚基 β

种属: Homo sapiens

同用名: PI3K; PIK3C1; P110BETA; PI3KBETA

基因 ID: 5291 | 基因类型: protein coding

关于 PIK3CB

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,652,698-138,834,928 (from NCBI)

This gene has 14 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 97 phenotypes. Ubiquitous expression in thyroid (RPKM 19.2), kidney (RPKM 9.0) and 25 other tissues.

功能概要

该基因编码磷酸肌醇 3-激酶 (PI3K) 催化亚基的同种型。这些激酶在涉及真核细胞外膜上受体的信号通路中很重要,并以其催化亚基命名。编码的蛋白质是 PI3Kbeta (PI3KB) 的催化亚基。 PI3KB 已被证明是嗜中性粒细胞激活途径的一部分,嗜中性粒细胞在损伤或感染部位结合了免疫复合物。可变剪接导致多个转录本变体。[RefSeq 提供,2011 年 12 月]

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or Infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

PIK3CB 基因产物(14)

mRNA Protein Name
XM_047448315.1 XP_047304271.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3
XM_047448310.1 XP_047304266.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448313.1 XP_047304269.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_047448311.1 XP_047304267.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_011512895.3 XP_011511197.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
NM_001256045.2 NP_001242974.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 2
XM_017006619.2 XP_016862108.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448314.1 XP_047304270.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_006713659.4 XP_006713722.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448307.1 XP_047304263.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448312.1 XP_047304268.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_047448308.1 XP_047304264.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448309.1 XP_047304265.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
NM_006219.3 NP_006210.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
IDA: 通过直接分析推断
12502714 GOA
enables kinase activity IDA
IDA: 通过直接分析推断
25327288 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19380743 GOA
enables protein serine kinase activity IDA
IDA: 通过直接分析推断
12502714 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
30496354 GOA
involved in negative regulation of sprouting angiogenesis IMP
IMP: 通过突变表型推断
30496354 GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway IGI
IGI: 通过遗传相互作用推断
30496354 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
30496354 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
18558630 GOA
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
12502714 GOA
acts upstream of or within phosphorylation IDA
IDA: 通过直接分析推断
25327288 GOA
involved in positive regulation of Rac protein signal transduction IGI
IGI: 通过遗传相互作用推断
18558630 GOA
involved in positive regulation of endothelial cell migration IGI
IGI: 通过遗传相互作用推断
18558630 GOA
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
25139353 GOA
involved in positive regulation of neutrophil apoptotic process IMP
IMP: 通过突变表型推断
25339672 GOA
acts upstream of or within positive regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
18558630 GOA
acts upstream of or within regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
25139353 GOA
involved in sphingosine-1-phosphate receptor signaling pathway IMP
IMP: 通过突变表型推断
18558630 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
30496354 GOA
part of phosphatidylinositol 3-kinase complex, class IA IPI
IPI: 通过物理相互作用推断
20713702 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PIK3CB 蛋白结构

PI3K_p85B

PI3K_p85B: PI3-kinase family, p85-binding domain (41 - 117)

PI3K_rbd

PI3K_rbd: PI3-kinase family, ras-binding domain (181 - 287)

PI3K_C2

PI3K_C2: Phosphoinositide 3-kinase C2 (350 - 470)

PI3Ka

PI3Ka: Phosphoinositide 3-kinase family, accessory domain (PIK domain) (534 - 708)

PI3_PI4_kinase

PI3_PI4_kinase: Phosphatidylinositol 3- and 4-kinase (801 - 1016)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1070 a.a.
蛋白主名 其他名称

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

PI3-kinase p110 subunit beta

PI3-kinase subunit beta

PI3K-beta

PtdIns-3-kinase p110

phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta

phosphoinositide-3-kinase, catalytic, beta polypeptide

ptdIns-3-kinase subunit beta

ptdIns-3-kinase subunit p110-beta

serine/threonine protein kinase PIK3CB

PIK3CB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PIK3CB P42338 PIK3R2 Homo sapiens O00459 32707033
种属内
PIK3CB P42338 PIK3R1 Homo sapiens P27986 33961781
种属内
PIK3CB P42338 PIK3R1 Homo sapiens P27986 32707033
种属内
PIK3CB P42338 PIK3R3 Homo sapiens Q92569 25814554
种属内
PIK3CB P42338 PIK3R1 Homo sapiens P27986-2 27107012
种属内
PIK3CB P42338 PIK3R1 Homo sapiens P27986-2 27107012
种属内
PIK3CB P42338 PIK3R1 Homo sapiens P27986-2
Y2H
27107012
种属间: 跨种属相互作用 种属内: 同种属相互作用

PIK3CB 抗体

目录号 产品名 应用 反应物种
HY-P81211 phospho-PI3 Kinase p110 beta (Ser1070) Antibody WB, ELISA, IHC-P, IHC-F, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple

Immunodeficiency 14

Activated Pi3k-Delta Syndrome

Apds

Pasli Disease

Imd14

Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation

P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Squamous Cell Skin Cancer

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi

Cloves Syndrome

Clove Syndrome

Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities

Clove Syndrome, Somatic

Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome

CLOVE

Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities

Congenital Arteriovenous Malformation

Arteriovenous Hemangioma

Nevus

Melanocytic Nevus

Benign Melanocytic Nevus

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Cowden Syndrome 1

Pten Hamartoma Tumor Syndrome

Bannayan-Riley-Ruvalcaba Syndrome

Lhermitte-Duclos Disease

Bannayan-Zonana Syndrome

Phts

Riley-Smith Syndrome

Bzs

Ruvalcaba-Myhre-Smith Syndrome

Multiple Hamartoma Syndrome

Rmss

Brrs

Dysplastic Gangliocytoma Of The Cerebellum

CWS1

Cs

Cd

Mham

Pten Hamartoma Tumor Syndrome With Granular Cell Tumor

Macrocephaly Multiple Lipomas And Hemangiomata

Bannayan-Ruvalcaba-Riley Syndrome

Myhre-Riley-Smith Syndrome

LDD

Cerebelloparenchymal Disorder Vi

Hamartoma Syndrome, Multiple

Bbrs

Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata

Macrocephaly, Multiple Lipomas, And Hemangiomata

Macrocephaly Pseudopapilledema And Multiple Hemangiomas

Ruvalcaba -Myhre-Smith Syndrome

Ruvalcaba-Myhre Syndrome

Cowden Disease

Macrocephaly Pseudopapilledema And Multiple Hemangiomata

Cerebellar Granule Cell Hypertrophy And Megalencephaly

Cpd6

Lhermitte-Duclos Syndrome

Pten Hamartoma Tumor Syndromes

Cowden Syndrome, Type 1

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Adenosquamous Prostate Carcinoma

Adenosquamous Carcinoma Of Prostate

Adenosquamous Carcinoma Of The Prostate

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Nk-Cell Enteropathy
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PIK3CB MGD MGI:1922019
Macaca mulatta PIK3CB VGNC VGNC:75996
Rattus norvegicus PIK3CB RGD RGD:620917
Canis familiaris PIK3CB VGNC VGNC:44556
Bos taurus PIK3CB VGNC VGNC:32890
Felis catus PIK3CB VGNC VGNC:68855
Others PIK3CB NCBI