1. Gene
  2. WDFY3 - WD repeat and FYVE domain containing 3 Gene

WDFY3 - WD repeat and FYVE domain containing 3 Gene

中文名称:含 WD 重复和 FYVE 结构域 3

种属: Homo sapiens

同用名: ALFY; BCHS; MCPH18; ZFYVE25

基因 ID: 23001 | 基因类型: protein coding

关于 WDFY3

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:84,669,597-84,966,690 (from NCBI)

This gene has 12 transcripts (splice variants), 231 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 8.6), brain (RPKM 8.1) and 25 other tissues.

功能概要

该基因编码一种磷脂酰肌醇 3-磷酸结合蛋白,作为自噬清除聚集体的主要导体。这种蛋白质从核膜穿梭到与聚集的蛋白质共定位,在那里它与其他自噬成分复合以实现巨自噬介导的这些聚集蛋白质的清除。然而,饥饿诱导的巨自噬并不是必需的。[RefSeq 提供,2010 年 5 月]

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by Autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with Other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]

WDFY3 基因产物(1)

mRNA Protein Name
NM_014991.6 NP_055806.2 WD repeat and FYVE domain-containing protein 3

WDFY3 蛋白结构

PH_BEACH

PH_BEACH: PH domain associated with Beige/BEACH (2539 - 2654)

Beach

Beach: Beige/BEACH domain (2695 - 2976)

WD40

WD40: WD domain, G-beta repeat (3119 - 3155)

WD40

WD40: WD domain, G-beta repeat (3205 - 3244)

FYVE

FYVE: FYVE zinc finger (3450 - 3514)

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  • 2400
  • 3000
  • 3526 a.a.
蛋白主名 其他名称

WD repeat and FYVE domain-containing protein 3

autophagy-linked FYVE protein

WDFY3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WDFY3 Q8IZQ1 GABARAP Homo sapiens Q6IAW1 24668264
种属内
WDFY3 Q8IZQ1 GABARAP Homo sapiens Q6IAW1
IF
24668264
种属内
WDFY3 Q8IZQ1 GABARAP Homo sapiens Q6IAW1 24668264
种属内
WDFY3 Q8IZQ1 GABARAP Homo sapiens Q6IAW1 24668264
种属内
WDFY3 Q8IZQ1 GABARAP Homo sapiens Q6IAW1
ITC
24668264
种属内
WDFY3 Q8IZQ1 ATG5 Homo sapiens Q9H1Y0 20417604
种属内
WDFY3 Q8IZQ1 ATG5 Homo sapiens Q9H1Y0 20417604
种属内
WDFY3 Q8IZQ1 ATG5 Homo sapiens Q9H1Y0 20417604
种属内
WDFY3 Q8IZQ1 MAP1LC3C Homo sapiens Q9BXW4 24668264
种属内
WDFY3 Q8IZQ1 MAP1LC3C Homo sapiens Q9BXW4 24668264
种属内
WDFY3 Q8IZQ1 SQSTM1 Homo sapiens Q13501 20168092
种属内
WDFY3 Q8IZQ1 SQSTM1 Homo sapiens Q13501 20168092
种属内
WDFY3 Q8IZQ1 SQSTM1 Homo sapiens Q13501 20417604
种属内
WDFY3 Q8IZQ1 SQSTM1 Homo sapiens Q13501 20168092
种属内
WDFY3 Q8IZQ1 SQSTM1 Homo sapiens Q13501 20168092
种属内
WDFY3 Q8IZQ1 MAP1LC3B Homo sapiens Q9GZQ8
IF
24668264
种属内
WDFY3 Q8IZQ1 MAP1LC3B Homo sapiens Q9GZQ8 20417604
种属内
WDFY3 Q8IZQ1 HTT Homo sapiens P42858 20417604
种属内
WDFY3 Q8IZQ1 HTT Homo sapiens P42858 20417604
种属内
WDFY3 Q8IZQ1 GABARAPL1 Homo sapiens Q9H0R8
ITC
24668264
种属内
WDFY3 Q8IZQ1 GABARAPL1 Homo sapiens Q9H0R8 24668264
种属内
WDFY3 Q8IZQ1 GABARAPL1 Homo sapiens Q9H0R8 24668264
种属间
WDFY3 Q8IZQ1 tax Human T-cell leukemia virus 1 P14079 22458338
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microcephaly 18, Primary, Autosomal Dominant

MCPH18

Primary Autosomal Dominant Microcephaly 18

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive

Autosomal Recessive Centronuclear Myopathy

CNM2

Centronuclear Myopathy 2

Ar-Cnm

Myotubular Myopathy, Autosomal Recessive

Autosomal Recessive Myotubular Myopathy

Centronuclear Myopathy Autosomal Recessive

Myopathy, Centronuclear, Type 2

Microcephaly 19, Primary, Autosomal Recessive

MCPH19

Primary Autosomal Recessive Microcephaly 19

Microcephaly, Type 19, Primary, Autosomal Recessive

Microcephaly, Autosomal Dominant

Autosomal Dominant Microcephaly

Microcephaly Autosomal Dominant

Autosomal Dominant Primary Microcephaly

Microcephaly With Autosomal Dominant Inheritance

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

Paget'S Disease Of Bone

Osteitis Deformans

Paget Disease Of Bone

Osseous Paget'S Disease

Paget Disease Of Bone, Familial

Bone Paget Disease

Familial Paget'S Disease Of Bone

Paget'S Bone Disease

Familial Paget Disease Of Bone

Paget Disease, Bone

Pdb

Pagets Bone Disease

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus WDFY3 MGD MGI:1096875
Bos taurus WDFY3 VGNC VGNC:36877
Felis catus WDFY3 VGNC VGNC:67011
Canis familiaris WDFY3 VGNC VGNC:48346
Rattus norvegicus WDFY3 RGD RGD:1307097
Macaca mulatta WDFY3 VGNC VGNC:79279