ATP6V1G2 - ATPase H+ transporting V1 subunit G2 Gene

中文名称：ATPase H+ 转运 V1 亚基 G2

种属: Homo sapiens

同用名: NG38; ATP6G; VMA10; ATP6G2

关于 ATP6V1G2

功能概要

该基因编码液泡 ATP 酶 (V-ATPase) 的一个组分，这是一种多亚基酶，可介导真核细胞胞内区室的酸化。 V-ATPase 依赖性酸化对于蛋白质分选、酶原激活、受体介导的内吞作用和突触小泡质子梯度生成等细胞内过程是必需的。 V-ATPase 由胞质 V1 结构域和跨膜 V0 结构域组成。 V1 结构域由三个 A 和三个 B 亚基、两个 G 亚基以及 C、D、E、F 和 H 亚基组成。 V1 域包含 ATP 催化位点。 V0 结构域由五个不同的亚基组成：a、c、c'、c'' 和 d。许多 V1 和 V0 亚基蛋白的其他亚型由多个基因或剪接的转录变体编码。这种编码的蛋白质是三个 V1 结构域 G 亚基蛋白质之一。该基因之前的基因符号为 ATP6G 和 ATP6G2。已经描述了编码不同亚型的选择性剪接转录物变体。该基因与下游 DEAD (Asp-Glu-Ala-Asp) 盒多肽 39B (DDX39B) 基因之间也存在通读转录。[RefSeq 提供，2011 年 2 月]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011]