SHFL - shiftless antiviral inhibitor of ribosomal frameshifting Gene

中文名称：核糖体移码的无转移抗病毒抑制因子

种属: Homo sapiens

同用名: SFL; IRAV; RyDEN; C19orf66

基因 ID: 55337 | 基因类型: protein coding

关于 SHFL

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,086,317-10,093,243 (from NCBI)

This gene has 11 transcripts (splice variants) and 136 orthologues. Ubiquitous expression in liver (RPKM 17.9), spleen (RPKM 17.5) and 25 other tissues.

功能概要

该基因是一种干扰素刺激基因 (ISG) ，可抑制病毒复制。编码的蛋白质结合核酸并抑制许多 RNA 病毒翻译所需的程序化 -1 核糖体移码。该蛋白抑制的病毒包括寨卡病毒、登革热病毒和冠状病毒 SARS-CoV 和 SARS-CoV2。[RefSeq 提供，2021 年 8 月]

This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, Dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]

SHFL 基因产物(2)

mRNA	Protein	Name
NM_001308277.2	NP_001295206.1	shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 2
NM_018381.4	NP_060851.2	shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	26735137	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	30682371	GOA
enables sequence-specific mRNA binding	IDA IDA: 通过直接分析推断	30682371	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in defense response to virus	IDA IDA: 通过直接分析推断	26735137	GOA
involved in defense response to virus	IMP IMP: 通过突变表型推断	27974568	GOA
involved in negative regulation of translational frameshifting	IDA IDA: 通过直接分析推断	30682371	GOA
involved in negative regulation of viral genome replication	IMP IMP: 通过突变表型推断	26735137	GOA
involved in regulation of translational termination	IDA IDA: 通过直接分析推断	30682371	GOA
involved in response to interferon-beta	IDA IDA: 通过直接分析推断	27974568	GOA
involved in response to type I interferon	IDA IDA: 通过直接分析推断	26735137	GOA
involved in response to type II interferon	IDA IDA: 通过直接分析推断	26735137	GOA
involved in response to type III interferon	IDA IDA: 通过直接分析推断	26735137	GOA
involved in viral translational frameshifting	IDA IDA: 通过直接分析推断	30682371	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in P-body	IDA IDA: 通过直接分析推断	27974568	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	26735137	GOA
located in nucleus	IDA IDA: 通过直接分析推断	26735137	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SHFL 蛋白结构

UPF0515

0
100
200
291 a.a.

蛋白主名

其他名称

shiftless antiviral inhibitor of ribosomal frameshifting protein

Repressor of yield of Dengue virus

SHFL 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SHFL	Q9NUL5	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	CCDC136	Homo sapiens	Q96JN2-2	Y2H Array	25416956
Intra	SHFL	Q9NUL5	CCDC136	Homo sapiens	Q96JN2-2	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	SHFL	Q9NUL5	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	SHFL	Q9NUL5	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	SHFL	Q9NUL5	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	25416956
Intra	SHFL	Q9NUL5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	CADPS	Homo sapiens	A2RRN7	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP2-3	Homo sapiens	P0C7H8	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	DRICH1	Homo sapiens	Q6PGQ1	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	SHFL	Q9NUL5	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
Intra	SHFL	Q9NUL5	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	SHFL	Q9NUL5	DTNBP1	Homo sapiens	Q96EV8	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	DTNBP1	Homo sapiens	Q96EV8	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SHFL	Q9NUL5	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	SHFL	Q9NUL5	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MAGEA1	Homo sapiens	P43355	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MAGEA1	Homo sapiens	P43355	Y2H Array	25416956
Intra	SHFL	Q9NUL5	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	SHFL	Q9NUL5	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	SHFL	Q9NUL5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Validated Y2H	25416956
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Y2H Array	25814554
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Y2H Array	25416956
Intra	SHFL	Q9NUL5	TNS2	Homo sapiens	Q63HR2	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I	Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome
Hsan1e	Hsan1
Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy	Hsn1e
Hsnie	Hereditary Sensory Neuropathy Type Ie
Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory And Autonomic Neuropathy Type 1e	Hereditary Sensory Neuropathy With Hearing Loss And Dementia
Dnmt1-Complex Disorder	Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss
Hsn Ie	Hereditary Sensory Autonomic Neuropathy, Type 1
Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Neuropathy, Hereditary Sensory, Type Ie

HSN1E	Hsn Ie
Hereditary Sensory Neuropathy Type 1e	Hereditary Sensory Neuropathy Type Ie
Hsan 1	Neuropathy, Hereditary Sensory, With Hearing Loss And Dementia
Hereditary Sensory Neuropathy Type 1	Hsn1
Hereditary Sensory And Autonomic Neuropathy Type 1	Neuropathy Hereditary Sensory And Autonomic Type 1
Neuropathy Hereditary Sensory Radicular, Autosomal Dominant	Neuropathy, Hereditary Sensory, 1e
Neuropathy Hereditary Sensory With Hearing Loss And Dementia	Neuropathy, Hereditary Sensory, Type I
Neuropathy, Sensory, Hereditary, Type Ie	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory Autonomic Neuropathy, Type 1

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12864	SHFL Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SHFL	VGNC	VGNC:77311
Bos taurus	SHFL	VGNC	VGNC:55202
Rattus norvegicus	SHFL	RGD	RGD:1565995
Mus musculus	SHFL	MGD	MGI:2441788
Canis familiaris	SHFL	VGNC	VGNC:52518

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