MTMR9 - myotubularin related protein 9 Gene

中文名称：肌微管蛋白相关蛋白 9

种属: Homo sapiens

同用名: MTMR8; C8orf9; LIP-STYX

基因 ID: 66036 | 基因类型: protein coding

关于 MTMR9

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,284,816-11,339,526 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 220 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 9.7), testis (RPKM 6.0) and 23 other tissues.

功能概要

该基因编码的肌微管蛋白相关蛋白与肌微管蛋白相关蛋白家族的大多数其他成员不同，因为它没有双特异性磷酸酶结构域。编码的蛋白质包含类似于 SET 相互作用结构域的双螺旋基序，这被认为在控制细胞增殖中起作用。在小鼠中，一种类似于编码蛋白的蛋白与 MTMR7 结合，它们一起使磷脂酰肌醇 3-磷酸和肌醇 1,3-二磷酸去磷酸化。[RefSeq 提供，2008 年 7 月]

This gene encodes a myotubularin-related protein that is atypical to most Other members of the myotubularin-related protein family because it has no dual-specificity Phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [provided by RefSeq, Jul 2008]

MTMR9 基因产物(1)

mRNA	Protein	Name
NM_015458.4	NP_056273.2	myotubularin-related protein 9

MTMR9 蛋白结构

Myotub-related

0
100
200
300
400
500
549 a.a.

蛋白主名

其他名称

myotubularin-related protein 9

inactive phosphatidylinositol 3-phosphatase 9

MTMR9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MTMR9	Q96QG7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
种属内	MTMR9	Q96QG7	MTMR7	Homo sapiens	Q9Y216	Anti Tag CoIP	28514442
种属内	MTMR9	Q96QG7	MTMR7	Homo sapiens	Q9Y216	Y2H Array	31515488
种属内	MTMR9	Q96QG7	MTMR7	Homo sapiens	Q9Y216	Anti Tag CoIP	27880917
种属内	MTMR9	Q96QG7	MTMR7	Homo sapiens	Q9Y216	Validated Y2H	32296183
种属内	MTMR9	Q96QG7	PTPN3	Homo sapiens	P26045	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	PTPN3	Homo sapiens	P26045	Y2H Array	32296183
种属内	MTMR9	Q96QG7	GRAMD4	Homo sapiens	Q6IC98	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	GRAMD4	Homo sapiens	Q6IC98	Y2H Array	32296183
种属内	MTMR9	Q96QG7	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
种属内	MTMR9	Q96QG7	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
种属内	MTMR9	Q96QG7	FAM169A	Homo sapiens	Q9Y6X4	Validated Y2H	32296183
种属内	MTMR9	Q96QG7	DEPDC5	Homo sapiens	O75140-2	Y2H Array	32296183
种属内	MTMR9	Q96QG7	DEPDC5	Homo sapiens	O75140-2	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	MOS	Homo sapiens	P00540	Y2H Array	31515488
种属内	MTMR9	Q96QG7	MOS	Homo sapiens	P00540	Y2H Prey Pooling	25416956
种属内	MTMR9	Q96QG7	MOS	Homo sapiens	P00540	Validated Y2H	25416956
种属内	MTMR9	Q96QG7	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
种属内	MTMR9	Q96QG7	VAC14	Homo sapiens	Q08AM6	Y2H Array	25416956
种属内	MTMR9	Q96QG7	VAC14	Homo sapiens	Q08AM6	Validated Y2H	25416956
种属内	MTMR9	Q96QG7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
种属内	MTMR9	Q96QG7	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
种属内	MTMR9	Q96QG7	NMI	Homo sapiens	Q13287	Y2H Array	25416956
种属内	MTMR9	Q96QG7	NMI	Homo sapiens	Q13287	Y2H Array	32296183
种属内	MTMR9	Q96QG7	NMI	Homo sapiens	Q13287	Y2H Prey Pooling	25416956
种属内	MTMR9	Q96QG7	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
种属内	MTMR9	Q96QG7	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
种属内	MTMR9	Q96QG7	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
种属内	MTMR9	Q96QG7	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
种属内	MTMR9	Q96QG7	EMILIN1	Homo sapiens	Q9Y6C2	Y2H Array	25416956
种属内	MTMR9	Q96QG7	EMILIN1	Homo sapiens	Q9Y6C2	Y2H Prey Pooling	25416956
种属内	MTMR9	Q96QG7	EMILIN1	Homo sapiens	Q9Y6C2	Validated Y2H	25416956
种属内	MTMR9	Q96QG7	MTMR8	Homo sapiens	Q96EF0	Anti Tag CoIP	27880917
种属内	MTMR9	Q96QG7	MTMR8	Homo sapiens	Q96EF0	Y2H Pooling	16189514
种属内	MTMR9	Q96QG7	MTMR8	Homo sapiens	Q96EF0	Anti Tag CoIP	33961781
种属内	MTMR9	Q96QG7	MTMR8	Homo sapiens	Q96EF0	Anti Tag CoIP	28514442
种属内	MTMR9	Q96QG7	MTMR6	Homo sapiens	Q9Y217	Anti Tag CoIP	27880917
种属内	MTMR9	Q96QG7	MTMR6	Homo sapiens	Q9Y217	Y2H Prey Pooling	32296183
种属内	MTMR9	Q96QG7	MTMR6	Homo sapiens	Q9Y217	Validated Y2H	32296183
种属内	MTMR9	Q96QG7	MTMR6	Homo sapiens	Q9Y217	Y2H Array	25416956
种属内	MTMR9	Q96QG7	MTMR6	Homo sapiens	Q9Y217	Y2H Array	32296183
种属内	MTMR9	Q96QG7	MTMR6	Homo sapiens	Q9Y217	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Keratolytic Winter Erythema

KWE	Oudtshoorn Skin Disease
Erythrokeratolysis Hiemalis Ichthyosis	Erythrokeratolysis Hiemalis
Oudtshoorn Skin	Oudtshoorn Disease

Osteopathia Striata With Cranial Sclerosis

Hyperostosis Generalisata With Striations	Robinow-Unger Syndrome
OSCS	Osteopathia Striata Cranial Sclerosis
Osteopathia Striata-Cranial Sclerosis Syndrome	Horan-Beighton Syndrome
Os-Cs	Osteopathia Striata - Cranial Sclerosis
Voorhoeve Disease	Osc

Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy	Xlmtm
X-Linked Centronuclear Myopathy	Xlcnm
CNMX	Mtm1
Myotubular Myopathy, X-Linked	Mtmx
Myotubular Myopathy 1	Centronuclear Myopathy X-Linked
Myotubular Myopathy	Mtm
Cnm	Xmtm
Myotubular Myopathy Type 1

Centronuclear Myopathy

Myopathy, Centronuclear	Myotubular Myopathy
Cnm	Myopathy, Myotubular
Congenital Structural Myopathy

Generalized Epilepsy With Febrile Seizures Plus

Gefs+	Genetic Epilepsy With Febrile Seizures Plus
Generalized Epilepsy With Febrile Seizures-Plus	Genetic Epilepsy With Febrile Seizures-Plus
Epilepsy, Generalized, With Febrile Seizures Plus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08795	MTMR9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MTMR9	VGNC	VGNC:43488
Macaca mulatta	MTMR9	VGNC	VGNC:74957
Bos taurus	MTMR9	VGNC	VGNC:50009
Mus musculus	MTMR9	MGD	MGI:2442842
Rattus norvegicus	MTMR9	RGD	RGD:628840
Felis catus	MTMR9	VGNC	VGNC:63656

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