2. Gene
  3. PTPN3 - protein tyrosine phosphatase non-receptor type 3 Gene

PTPN3 - protein tyrosine phosphatase non-receptor type 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酪氨酸磷酸酶非受体 3 型

种属: Homo sapiens

同用名: PTPH1; PTP-H1

基因 ID: 5774 | 基因类型: protein coding

关于 PTPN3

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:109,375,694-109,538,420 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 9.4), kidney (RPKM 7.8) and 21 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该蛋白包含一个 C 端 PTP 结构域和一个 N 端结构域，与细胞骨架相关蛋白的带 4.1 超家族同源。 p97 是一种参与多种膜相关功能的细胞周期调节剂，已被证明是该 PTP 的底物。还发现此 PTP 与衔接蛋白 14-3-3 beta 相互作用并受其调节。已经为该基因发现了几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2009 年 2 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. p97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

PTPN3 基因产物(6)

mRNA Protein Name
NM_001145368.2 NP_001138840.1 tyrosine-protein phosphatase non-receptor type 3 isoform 2
NM_001145369.2 NP_001138841.1 tyrosine-protein phosphatase non-receptor type 3 isoform 3
NM_001145370.2 NP_001138842.1 tyrosine-protein phosphatase non-receptor type 3 isoform 4
NM_001145371.2 NP_001138843.1 tyrosine-protein phosphatase non-receptor type 3 isoform 5
NM_001145372.2 NP_001138844.1 tyrosine-protein phosphatase non-receptor type 3 isoform 6
NM_002829.4 NP_002820.3 tyrosine-protein phosphatase non-receptor type 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
10364224 GOA
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
10364224 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9341175 GOA
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
19167335 GOA
enables sodium channel regulator activity IDA
IDA: 通过直接分析推断
16930557 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
12207026 GOA
involved in negative regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
10364224 GOA
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
10364224 GOA
involved in regulation of membrane depolarization during action potential IDA
IDA: 通过直接分析推断
16930557 GOA
involved in regulation of sodium ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
16930557 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10940933 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
10940933 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPN3 蛋白结构

FERM_N

FERM_N: FERM N-terminal domain (33 - 111)

FERM_M

FERM_M: FERM central domain (113 - 222)

FERM_C

FERM_C: FERM C-terminal PH-like domain (228 - 312)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (511 - 594)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (670 - 899)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 913 a.a.
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 3

cytoskeletal-associated protein tyrosine phosphatase

PTPN3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTPN3 P26045 DIP2A Homo sapiens Q14689-6
Validated Y2H
25416956
种属内
PTPN3 P26045 DIP2A Homo sapiens Q14689-6
Y2H Array
25416956
种属内
PTPN3 P26045 VANGL2 Homo sapiens Q9ULK5
Anti Tag CoIP
28330616
种属内
PTPN3 P26045 VANGL2 Homo sapiens Q9ULK5
Pull Down
28330616
种属内
PTPN3 P26045 SDHA Homo sapiens P31040
Pull Down
28330616
种属内
PTPN3 P26045 SDHA Homo sapiens P31040
Anti Tag CoIP
28330616
种属间
PTPN3 P26045 E6 Human papillomavirus P06463
Pull Down
17947517
种属间
PTPN3 P26045 E6 Human papillomavirus P06463
CoIP
17947517
种属内
PTPN3 P26045 SRCAP Homo sapiens Q6ZRS2-3
Validated Y2H
32296183
种属内
PTPN3 P26045 VWA2 Homo sapiens Q5GFL6-3
Validated Y2H
32296183
种属内
PTPN3 P26045 WDR6 Homo sapiens Q9NNW5
Validated Y2H
32296183
种属内
PTPN3 P26045 EPS15 Homo sapiens P42566-1
X-Ray Diffraction
25728925
种属内
PTPN3 P26045 EPS15 Homo sapiens P42566-1
FPS
25728925
种属内
PTPN3 P26045 EPS15 Homo sapiens P42566-1
Anti Tag CoIP
25728925
种属内
PTPN3 P26045 EPS15 Homo sapiens P42566-1
Phosphatase Assay
25728925
种属内
PTPN3 P26045 AKR1C1 Homo sapiens Q04828
Y2H Prey Pooling
25416956
种属内
PTPN3 P26045 AKR1C1 Homo sapiens Q04828
Validated Y2H
32296183
种属内
PTPN3 P26045 AKR1C1 Homo sapiens Q04828
Y2H Array
32296183
种属内
PTPN3 P26045 TFAP4 Homo sapiens Q01664
Validated Y2H
32296183
种属内
PTPN3 P26045 VDR Homo sapiens P11473
Anti Tag CoIP
21119599
种属内
PTPN3 P26045 MCC Homo sapiens P23508
Anti Tag CoIP
28330616
种属内
PTPN3 P26045 MCC Homo sapiens P23508
Pull Down
28330616
种属内
PTPN3 P26045 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
PTPN3 P26045 YWHAZ Homo sapiens P63104
BioID
28330616
种属内
PTPN3 P26045 YWHAZ Homo sapiens P63104
Pull Down
28330616
种属内
PTPN3 P26045 YWHAZ Homo sapiens P63104
Anti Tag CoIP
27880917
种属内
PTPN3 P26045 VCP Homo sapiens P55072
Pull Down
10364224
种属内
PTPN3 P26045 YWHAB Homo sapiens P31946
Pull Down
28330616
种属内
PTPN3 P26045 YWHAB Homo sapiens P31946
Anti Tag CoIP
27880917
种属内
PTPN3 P26045 YWHAB Homo sapiens P31946
BioID
28330616
种属内
PTPN3 P26045 YWHAB Homo sapiens P31946
Pull Down
9341175
种属内
PTPN3 P26045 YWHAG Homo sapiens P61981
BioID
28330616
种属内
PTPN3 P26045 YWHAG Homo sapiens P61981
Anti Tag CoIP
27880917
种属内
PTPN3 P26045 YWHAG Homo sapiens P61981
Pull Down
28330616
种属内
PTPN3 P26045 YWHAG Homo sapiens P61981
Y2H Pooling
20936779
种属内
PTPN3 P26045 ZCCHC10 Homo sapiens Q8TBK6
Y2H Prey Pooling
25416956
种属内
PTPN3 P26045 ZCCHC10 Homo sapiens Q8TBK6
Validated Y2H
25416956
种属内
PTPN3 P26045 VANGL1 Homo sapiens Q8TAA9
Anti Tag CoIP
28330616
种属内
PTPN3 P26045 VANGL1 Homo sapiens Q8TAA9
BioID
28330616
种属内
PTPN3 P26045 VANGL1 Homo sapiens Q8TAA9
Pull Down
28330616
种属内
PTPN3 P26045 VANGL1 Homo sapiens Q8TAA9
Anti Tag CoIP
27880917
种属内
PTPN3 P26045 TRIM41 Homo sapiens Q8WV44
Validated Y2H
32296183
种属内
PTPN3 P26045 SCN5A Homo sapiens Q14524
Pull Down
16930557
种属内
PTPN3 P26045 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
种属内
PTPN3 P26045 MLH1 Homo sapiens P40692
Validated Y2H
32296183
种属内
PTPN3 P26045 MTMR9 Homo sapiens Q96QG7
Validated Y2H
32296183
种属内
PTPN3 P26045 TENT5D Homo sapiens Q8NEK8
Validated Y2H
32296183
种属内
PTPN3 P26045 NXT2 Homo sapiens Q9NPJ8
Validated Y2H
25416956
种属内
PTPN3 P26045 NXT2 Homo sapiens Q9NPJ8
Y2H Array
25416956
种属内
PTPN3 P26045 LMO1 Homo sapiens P25800
Y2H Array
25416956
种属内
PTPN3 P26045 LMO1 Homo sapiens P25800
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma
Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications
Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency

HHF5

Familial Hyperinsulinemic Hypoglycemia 5

Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

Congenital Hyperinsulinism

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

Hyperinsulinemic Hypoglycemia Familial 5
Monocarboxylate Transporter 1 Deficiency

Ketoacidosis Due To Monocarboxylate Transporter-1 Deficiency

MCT1D

Ketosis
Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Myopathy

Muscular Diseases

Myopathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11426 PTPN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PTPN3 VGNC VGNC:33538
Felis catus PTPN3 VGNC VGNC:69163
Rattus norvegicus PTPN3 RGD RGD:1311363
Canis familiaris PTPN3 VGNC VGNC:45176
Macaca mulatta PTPN3 VGNC VGNC:76604
Mus musculus PTPN3 MGD MGI:105307
Others PTPN3 NCBI
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