2. Gene
  3. WDR6 - WD repeat domain 6 Gene

WDR6 - WD repeat domain 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WD 重复域 6

种属: Homo sapiens

同用名: Trm734

基因 ID: 11180 | 基因类型: protein coding

关于 WDR6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,007,391-49,015,951 (from NCBI)

This gene has 22 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in ovary (RPKM 54.4), endometrium (RPKM 45.4) and 25 other tissues.

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域，通常由 gly-his 和 trp-asp (GH-WD) 括起来，这可能有助于异源三聚体或多蛋白复合物的形成。编码的蛋白质与丝氨酸/苏氨酸激酶 11 相互作用，并与细胞生长停滞有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

WDR6 基因产物(3)

mRNA Protein Name
NM_001320546.3 NP_001307475.1 WD repeat-containing protein 6 isoform 2
NM_001320547.2 NP_001307476.1 WD repeat-containing protein 6 isoform 3
NM_018031.6 NP_060501.4 WD repeat-containing protein 6 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme regulator activity IDA
IDA: 通过直接分析推断
32558197 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17216128 GOA
enables tRNA binding IDA
IDA: 通过直接分析推断
32558197 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of negative effect G1 to G0 transition IPI
IPI: 通过物理相互作用推断
17216128 GOA
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
22354037 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
17216128 GOA
involved in wobble position ribose methylation IDA
IDA: 通过直接分析推断
32558197 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COP9 signalosome IDA
IDA: 通过直接分析推断
18850735 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17216128 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WDR6 蛋白结构

WD40

WD40: WD domain, G-beta repeat (204 - 237)

WD40

WD40: WD domain, G-beta repeat (255 - 284)

WD40

WD40: WD domain, G-beta repeat (300 - 326)

WD40

WD40: WD domain, G-beta repeat (971 - 1010)

  • 0
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  • 1000
  • 1121 a.a.
蛋白主名 其他名称

WD repeat-containing protein 6

Trm734 homolog

WDR6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
32296183
种属内
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Array
25416956
种属内
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Array
32296183
种属内
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Validated Y2H
25416956
种属内
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
25416956
种属内
WDR6 Q9NNW5 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Prey Pooling
32296183
种属内
WDR6 Q9NNW5 GRIP1 Homo sapiens Q9Y3R0-3
Validated Y2H
32296183
种属内
WDR6 Q9NNW5 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Array
32296183
种属内
WDR6 Q9NNW5 STK11 Homo sapiens Q15831
Y2H
17216128
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tumoral Calcinosis, Normophosphatemic, Familial

Normophosphatemic Familial Tumoral Calcinosis

NFTC

Tumoral Calcinosis, Familial, Normophosphatemic

Calcinosis, Tumoral, With Normophosphatemia

Familial Normophosphatemic Tumoral Calcinosis

Tumoral Calcinosis With Normophosphatemia
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15790 WDR6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus WDR6 VGNC VGNC:36908
Macaca mulatta WDR6 VGNC VGNC:78790
Rattus norvegicus WDR6 RGD RGD:1307649
Mus musculus WDR6 MGD MGI:1930140
Canis familiaris WDR6 VGNC VGNC:48378
Felis catus WDR6 VGNC VGNC:67043
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